1,511 search results for “stress exposure” in the Public website
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OPENup: Optimizing exposure therapy for Posttraumatic Stress disorder
Although exposure therapy is the gold-standard treatment of posttraumatic stress-disorder (PTSD), only half of the patients adequately benefit from it. Based on recent insights into the mechanisms of extinction, this project examines strategies and techniques to improve exposure treatment outcome in…
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Dynamics and regulation of the oxidative stress response upon chemical exposure
The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…
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Zebrafish personality, stress physiology and behaviour in the context of sound exposure
To what extent is sound a stressor to fish? And are behavioural and physiological phenotypes equally sensitive to disturbance by noise pollution?
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Reducing daily-stress breaking a habit
With this thesis the PhD-candidate aims to enrich the body of evidence concerning the relation between stress and health, and the mediating role of (un)conscious perseverative cognitions, which is captured in the extended perseverative cognition hypothesis.
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Pesticides and health – challenges and opportunities for exposure assessment
The aim is to develop methods to assess environmental and occupational exposure to (individual) pesticides, to be applied in epidemiological studies investigating pesticide exposure and human health. Furthermore, we aim to investigate the potential association between exposure to pesticides and Parkinson’s…
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The neurobiology of depression and the relation between stress, mental health, ageing and chronic illness
I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.
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Psychophysiological responses to stress and stress management
The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.
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Swimming Bass under Pounding Bass: fish response to sound exposure
Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn
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Unfolding the regulation of stress response pathways upon liver injury
Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.
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Topic: Stress and stress-related disorders
The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…
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Stress, hormones and emotion regulation
What is the role of stress and stress-related hormones in emotion regulation?
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Mathematical modeling of cellular stress pathways for mechanistic understanding of chemical-induced liver injury
Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…
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24-hour rhythms in drug exposure and effect
Although rarely considered by the pharmaceutical industry or clinicians, 24-hour rhythms in physiology are a factor of potential influence on the pharmacokinetics and pharmacodynamics of drugs.
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Knowledge centre Anxiety & Stress in Youth
Our mission is to recognise and treat stress and anxiety in children as early as possible, by connecting scientific research, clinical practice and education.
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A PCAD-model for fish to study the impact of airgun sound exposure on free-ranging cod
We are developing the conceptual framework, which is new to this taxonomic group, and evaluate the current state of the art with respect to all critical parameters and transfer functions for a fully developed Population Consequences of Acoustic Disturbance (PCAD) model.
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Stress-related prolonged cardiovascular activity: The impact and changeability of stressful cognition without awareness
The research question is that unconscious perseverative cognition (UPC) is responsible for a considerable part of cardiovascular (CV) activity that occurs even in the absence of threats and other stressors that one may encounter in one’s daily life.
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Stress Lessons in secondary education: The effectiveness and evaluation of a school-based psychoeducation program about stress
Does a universal psychoeducational course about stress in adolescents: I) lead to an increase in knowledge of stress?, II) affect the frequency with which stressors are experienced and the overall stress level?, III) create interest in a tier 2 level follow-up training?, and IV) appeal to students in…
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Stress or study delay?
Being a student can be stressful. Study pressure, living on your own, moving country, financial stress: things can be difficult. Unexpected difficulties may lead to study delay.
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What Works in Preventing Emerging Social Anxiety: Exposure, Cognitive Restructuring, or a Combination?
Programs that aim to reduce symptoms of social anxiety in children generally include multiple components, such as exposure and cognitive restructuring. It is unknown if separate components yield positive intervention effects in children or whether a combination of components is required.
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LIBC Stress & Emotion
All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.
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Endocannabinoids in health and stress
How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?
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Stress Less Project: Effectiveness of school-based intervention programs
What is the effectiveness of two school-based skills-training programs in promoting mental health?
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What is the effect of long-term exposure to engineered nanomaterials (ENMS)?
Engineered nanomaterials (ENMs) are widely used, and nanotechnological innovations grow with rapid pace. Studies on nanotoxicology have demonstrated that chemical toxicology as well as particle toxicology should be accounted for in predicting the safety of ENMs.
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Rianne de Kleine
Faculteit der Sociale Wetenschappen
r.a.de.kleine@fsw.leidenuniv.nl | +31 71 527 5435
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Memory boost: A novelty-exposure intervention to counteract memory decline.
This project aims to identify which aspects of exploring a novel environment produce beneficial effects on memory. The effects of novelty will be investigated across the lifespan, including children, adolescents and older adults.
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Role of epigenetics in long-term health effects of early life stress
Can epigenetic changes explain associations between early life stress and health outcomes?
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Marike Kooistra
Faculteit der Sociale Wetenschappen
m.j.kooistra@fsw.leidenuniv.nl | +31 71 527 1726
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Early recognition and intervention of stress and anxiety in the classroom
How can we facilitate the early recognition of stress and anxiety in the classroom and collaborate with schools in providing low-threshold interventions?
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Danielle Oprel
Faculteit der Sociale Wetenschappen
d.a.c.oprel@fsw.leidenuniv.nl | +31 71 527 2727
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Research
Although there has been an increase in the research into brain function and dysfunction in relation to stress and emotions, there are still many unanswered questions.
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Microbial Induction of Plant Resilience to Drought Stress (MicroRes)
What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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The effects of stress and fear on nocebo hyperalgesia
What role play stress and fear in forming of nocebo hyperalgesia?
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Choice-related stress and uncertainty
What are the behavioral, cognitive, and motivational consequences of decision reversibility?
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Jos Brosschot
Faculteit der Sociale Wetenschappen
brosschot@fsw.leidenuniv.nl | +31 71 527 3740
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Structural characterization of the cell envelope of Actinobacteria under changing environments
Bacteria have the ability to alter their morphology in order to adapt to changing environments.
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The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
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Jin Yan
Faculteit der Sociale Wetenschappen
j.yan@fsw.leidenuniv.nl | +31 71 527 2727
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The 3Generation study: Stress and Emotions in a Family Context
What is the role of neuronal emotional reactivity in the intergenerational transmission of abuse?
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The noisy underwater world: the effect of sound on behaviour of captive zebrafish
Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn
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Personal chair in ‘Stress-related psychopathology’ for Bernet Elzinga
Clinical psychologist Bernet Elzinga has been appointed as Professor of a personal chair at the Faculty of Social and Behavioural Sciences. This professorship will contribute both nationally and internationally to the broader promotion of Leiden University in the field of stress and psychopathology.
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that never happen: Genaralized unsafety and prolonged psysiological stress responses
The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Monitoring drought and salinity stress in agriculture by remote sensing for a sustainable future
Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…
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High throughput microscopy for cellular adaptive stress response pathways in drug adversity
High throughput microscopy
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The rhizomicrobiome of Sorghum ; impact on plant growth and stress tolerance
The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.
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Jasper Maas
Faculteit der Sociale Wetenschappen
j.n.m.maas@fsw.leidenuniv.nl | +31 71 527 2727
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From stress to success: how actinobacteria exploit life without a cell wall
The central question of this Vici proposal is to investigate if, and how actinobacteria exploit life without a cell wall.