685 search results for “exposure therapie” in the Public website
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Philip Spinhoven
Faculteit der Sociale Wetenschappen
spinhoven@fsw.leidenuniv.nl | +31 71 527 2727
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Lioe-Fee de Geus-Oei
Faculteit Geneeskunde
l.f.de_geus-oei@lumc.nl | +31 71 526 9111
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Willem van der Does
Faculteit der Sociale Wetenschappen
vanderdoes@fsw.leidenuniv.nl | +31 71 527 8482
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Oana Georgiana Rus-Oswald
Faculteit der Sociale Wetenschappen
o.g.rus@fsw.leidenuniv.nl | +31 71 527 2727
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Cancer Therapeutics and Drug Safety
In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…
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BAT: Breaking the Transmission of Anxiety in the Family
Parents may pass anxiety onto their offspring by exposing them to anxious behaviors in novel situations. Just as the parents’ anxious signals lead to anxiety, parents’ confident signals can ward off anxiety in the offspring. This project is seeking a new way to break anxiety transmission in the family…
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Programme structure
The master's specialisation Child and Adolescent Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.
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Develop a methodology for assessing the effective dose of nanomaterials for environmental risk assessment purposes
How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?
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KiBA Testing the App
Children with a specific phobia are excessively afraid of certain objects, animals or situations. Specific phobias are common in children, but they can make the child’s life at home, school and outside quite difficult. Together with a large international team, we developed the KibA-program to help children…
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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The neurobiology of depression and the relation between stress, mental health, ageing and chronic illness
I want to understand the overlap between physical health, mental health, and healthy aging and whether/how stress (behaviorally and biologically) may tie these concepts together.
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Optimizing antifungal treatment through pharmacometrics: dosing considerations to enhance outcome
Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Predicted microplastic uptake through trophic transfer by the short-beaked common dolphin and common bottlenose dolphin
In this study, Tessa Dool and Thijs Bosker estimate the microplastic uptake of two odontocetes in the Mediterranean Sea and the Norteast Atlantic.
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Structural characterization of the cell envelope of Actinobacteria under changing environments
Bacteria have the ability to alter their morphology in order to adapt to changing environments.
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Integrating cellular and tissue dynamics with cell fate decisions through computational modeling
There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…
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Research
Although there has been an increase in the research into brain function and dysfunction in relation to stress and emotions, there are still many unanswered questions.
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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Unraveling the role of signaling networks controlled by Grainyhead like transcription factor in breast cancer subtypes
This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…
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Preclinical therapy development in FSHD
PhD defence
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Stem cells as cure
Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.
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Programme structure
Courses cover a broad range of relevant subjects and provide in-depth theoretical knowledge as well as training in practical skills and advanced research tools.
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Courses offered
In the academic year 2023-2024 the SRS interdisciplinary programme will offer four courses for interested students who are entering the third year of their Bachelor's degree. You can sign up for these courses in your elective (minor) space. You can follow the courses individually as an elective, or…
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GLOBOX
GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Immuno-photodynamic therapy of cancer
PhD defence
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Leiden Index of Depression Sensitivity
The Leiden Index of Depression Sensitivity (LEIDS) measures cognitive reactivity (CR) to sadness, an aspect of cognitive vulnerability to depression, conceptually similar to rumination.
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An online self-help programme for people with HIV and depressive symptoms
To investigate the effectiveness of an online self-help programme for people with HIV and depressive symptoms.
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Why MT3 at Leiden University and the Autonomous University of Barcelona?
The collaboration between Leiden University (Medical Center) and the Autonomous University of Barcelona forms one of the most powerful international alliances for the creation and transmission of knowledge in the field of transfusion medicine.
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Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
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Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
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New professor wants to improve care for sarcoma patients
Doctors should work with patients with bone and soft-tissue tumours to find the best personal treatment strategy says Prof. Michiel den de Sande. He has developed an app that helps choose the right treatment. Van de Sande was appointed Professor of Orthopaedics with a particular focus on paediatric…
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Ethnic disadvantage and adolescents’ emotional- and behavioural problems
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Fighting tumours with light
Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.
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Computational modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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Stromal cells suppress immune response symptoms
A new therapy for the serious Graft-versus-Host disease
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Admission and application
Find out how to apply for Transfusion Medicine and Cellular and Tissue Therapies.
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Chemical biology of sphingolipids: fundamental studies and clinical applications
Overkleeft
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Development of a consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
How to improve the method in quantifying the combined effects of metal-based chemicals?
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Antithrombotic therapy in the Netherlands- New insights from nationwide data
PhD defence
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Epilepsy and anxiety: targeting a vicious cycle
How effective is eye movement desensitization and reprocessing therapy in targeting epilepsy-related anxiety?
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Sylvestre Bonnet
Science
bonnet@chem.leidenuniv.nl | +31 71 527 4260
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Oncode Accelerator
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…
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Tailor-made medicines
More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.
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Effects of pesticides on aquatic macrofauna in the field
Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver
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Mathematical modeling of cellular stress pathways for mechanistic understanding of chemical-induced liver injury
Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…
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Functionalizing monolayer graphene as a proton-selective membrane for direct methanol fuel cells
This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.