1,394 search results for “treatment” in the Public website
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modeling of pharmacokinetics and tumor dynamics to guide anti-cancer treatment
PhD defence
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Replacing fear with something new: Using novelty to unlearn fear.
This project has two main aims: I. Determine when novelty promotes fear extinction. II. Discover the neurobiological mechanisms underlying these effects.
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Female professors from the present and the future
Role models are key to inspiring the next generation. Fifteen female professors therefore celebrated International Women's Day with girls aged between 12 and 16. Because although the number of women at the (academic) top is increasing, we're not there yet.
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Experimental Studies on the Normative Force of Law: The Problem of 'Treatment Resistance'
Lecture
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of nanocarriers to improve the effectiveness of colorectal cancer treatment
PhD defence
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Preclinical validation of putative targets in cardiovascular and metabolic disease
Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.
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Research
The main focus of our research programme is on adolescence, a key transitional period in human development. The programme puts emphasis on combined experimental behavioural and neural analysis of normative transitions and deviations in adolescent development.
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Topic: Spatial thinking
Our everyday life consists of all sorts of spatial processes: we find our way to work, remember where we left our keys, and are able to pick up our cup of coffee. We study how the human brain processes such spatial processes. From a clinical perspective, we are interested in how acquired brain damage…
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Green defense against thrips- Exploring natural products for early management of western flower thrips
As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).
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People and Projects
Our team consists of the following members.
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Blended Care for Adolescents with Social Anxiety
Is blended care a feasible and effective treatment method for social anxiety in adolescence?
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A good start: Early prevention of anti-social behavior
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Systems pharmacology of human neuroendocrine disease entities
An important hormone excreting gland in the human body is the pituitary
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Routine Outcome Monitoring and Feedback in Psychological Therapies
Kim de Jong, Jaime Delgadillo, and Michael Barkham offer valuable insights in their book 'Routine Outcome Monitoring and Feedback in Psychological Therapies' on how therapists and trainees can use feedback to inform treatment decisions and, ultimately, enhance patient outcomes.
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Polymers in the Liver: Metabolism and Regulation
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Sensing & Stimulation (MSc)
In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…
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Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
- Designing Modulators of Purinergic Signaling for Chronic Disease Treatment
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Photodynamic therapy-based combinations with immunotherapy in colon cancer treatment
PhD defence
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Forum Antiquum Lecture Spring 2022: 'Christiani et Ceteri. The Treatment of Christians in the Roman Empire'
Lecture
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Annemarie Drahmann on new European regulations for stallholders
There is much unrest among local stallholders in Utrecht. Owners who for decades had a permanent pitch for their stall are no longer guaranteed this due to new European regulations. So no more benefits for the current stallholders which is causing them great uncertainty and frustration.
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Research
Research lines within the Pharmacy group:
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Research ecosystem
The chain that supplies patients with new medicines consists of various complex links: from fundamental research to clinical tests and production. This entire chain is represented in Leiden. Leiden University, the Leiden University Medical Center (LUMC), and the companies on the Leiden Bio Science Park…
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UM Cure 2020: New therapies for uveal melanoma
Can we bring novel treatment options to the clinic for UM patients with liver metastases?
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Research
The Institute of Psychology is responsible for innovative and interdisciplinary research and education within psychology and related disciplines. It focuses primarily on four broad areas: Health and Wellbeing; Development and Learning; Socio-Cognitive-Affective Decision-making and Advanced Behavioural…
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Patient derived zebrafish xenograft models for personalized treatment of uveal melanoma
PhD defence
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Concerns and opportunities related to discontinuation of treatment in rheumatoid arthritis
PhD defence
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Treatment with anti-CGRP (receptor) antibodies for migraine: Can we predict effectiveness?
PhD defence
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Bridging the gap, Pelvic floor physical therapy in the treatment of chronic anal fissure
PhD defence
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Defining optimal oncolytic virus treatment and diagnostics in high risk melanoma patients
PhD defence
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signaling and inflammation: metabolomics for better diagnosis and treatment strategy
PhD defence
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Treatment optimisation and pharmacogenetics of systemic and intraperitoneal chemotherapy in colorectal cancer
PhD defence
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In vitro models of bone-forming tumours: from target to treatment
PhD defence
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Genomic driven treatment and drug rediscovery in patients with advanced cancer
PhD defence
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Biomedical Imaging
The rapid advances in imaging technology enable to see inside the body with ever increasing detail.
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Novel chemical tools for target validation in neuroinflammation
In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?
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Prediction of human gut (colon cancer) target site concentrations and PKPD relationships
The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.
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Innovative (electro-driven) sample preparation tools for metabolomics study of muscle aging
This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.
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Immunity, Infection and Tolerance
The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.
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Health Data Science
Health research, medical practice and consequently the whole population is increasingly affected by digitization, data science and AI.
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Cancer Pathogenesis and Therapy
Cancer represents a formidable current and future global health challenge. The LUMC medical research profile Cancer Pathogenesis and Therapy charges this challenge by developing and implementing innovative patient-tailored, multimodal diagnostic methods and treatment modalities.
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The rights of the developing child
As children learn, develop and acquire more skills, their legal position also changes. Professor of Children’s Rights Ton Liefaard works closely together with Leiden social sciences researchers to shed light on these growing capacities and their implications for our legal system. ‘Our ideas about children’s…
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Healthy ageing
The elderly accept may minor discomforts like stiffer muscles and getting tired more quickly, but they do want to go to their children's birthdays independently. Preventive elderly care helps people with that. The goal is to let people grow old while maintaining their self-reliance and independence…