This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Since the global COVID-19 pandemic, the coronavirus responsible (SARS-CoV-2) has been extensively probed for promising protein targets to establish drug-based therapies.

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

How do protein modifications work together to repair DNA, and what can we learn about these interactions to better understand disease?

Sustainable rose smell that can be produced on a large scale. Tobias Fecker made this into a possibility during his master's thesis, which was a collaboration between the IBL and the TU Delft. He wins the fourth edition of the Krijn Rietveld Memorial Innovation Award.

Rose Vossen has been named winner of the Young Star Award 2021. The Life Science and Technology student received the award on Monday from Ewine van Dishoeck, the founder of the award. Vossen wins a cheque for 2,500 euros for her exceptional results as a bachelor's student. During her final bachelor…

Els Rose has received an honorary doctorate from the University of Lausanne. Rose is professor of late and medieval Latin at Utrecht University. The committee commended Rose for “ her original research, that has contributed to an understanding of the breadth and depth of the reception of texts and traditions…

Health psychologist Aleksandrina Skvortsova has made clever use of the Pavlov effect to link the ‘cuddle’ hormone oxytocin with the placebo effect. This effect can alter the level of oxytocin in the body, making it possible for people to reduce the amount of medicine they need while still feeling good.…

Dr. Cecily Rose, Associate Professor at the Grotius Centre for International Legal Studies, has appointed by the Dutch Government to the Advisory Committee on Public International Law, with effect as of 1 January 2025.

The monthly ILS Lunch seminars bring together colleagues and students from Leiden Law School, providing an informal setting to hear what researchers from other research programs and institutes are working on. On Thursday 12 December 2019, the final ILS Lunch Seminar of this year takes place. This month,…

Sophie Rose is one of the fellows of the Ammodo Science Fellowship 2024. She will use this fellowship to conduct research at Leiden University.

On 30 November 2016, Cecily Rose participated in a Symposium held at the T.M.C. Asser Institute on 'A Court for the World? Trust in the ICJ 50 years after South West Africa'.

PhD defence

Buying chocolates as a sign of love, getting the best deals on Black Friday and putting on a spooky costume for Halloween. In recent years, these holidays and traditions have taken off in the Netherlands, even though they originated on the other side of the ocean. Why are we so excited about American…

The Register of Early Modernists aims to facilitate collaboration between early modern researchers at Leiden University.

A team of researchers at Leiden University is collecting information about the methods used by researchers in the field of public international law. The research team consists of Cecily Rose, Misha Plagis, Johanna Trittenbach, and Nicholas McGuire. The goal of this research project is to understand…

The book is written for students working in a range of disciplines, and provides an accessible, balanced and nuanced introduction to the field of public international law. It explains the basic concepts and legal frameworks of public international law while acknowledging the field’s inherent complexities…

PhD defence

While the Netherlands was in lockdown because of the coronavirus, PhD candidate Koen Rijpkema began his research into the same virus. In the lab, he developed molecules that can inhibit an important viral enzyme.

Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.

Join-in courses zijn MA-cursussen over middeleeuwse onderwerpen gegeven binnen vastgestelde MA-programma's van de zes deelnemende universiteiten van de Onderzoekschool. Op aanvraag zijn deze vakken toegankelijk voor studenten van andere (Nederlandse) universiteiten. De cursusbelasting en het aantal…

The historical archaeology of the Port of Sandy Point and its anchorage, St. Kitts, West Indies

This commentary on the United Nations Convention Against Corruption discusses each provision of the treaty, traces the provisions’ drafting history, and explores their implementation in domestic legal systems.

On 17 August 1945, two days after the Japanese surrender that also brought an end to the Second World War in Asia, Indonesia declared its independence. The declaration was not recognized by the Netherlands, which resorted to force in its attempt to take control of the inevitable process of decolonization.…

The Common Market Law Review has an internationally composed Editorial Board and Advisory Board.

Research at the Grotius Centre for International Legal Studies is primarily carried out under its Research Programme ‘Exploring the Frontiers of International Law’.

The Grotius Centre Working Paper Series is an occasional series through which researchers in the Grotius Centre can publish the unedited versions of manuscripts that have been accepted for publication by journals and books.

Meet the scientists within the LED3 community

FluidKnowledge will investigate the past, present and future of evaluating ocean science. Regarding the past, it will ask how research priorities in ocean science evolved until now. Which lines of inquiry became hot topics, and which died out? Who became global players, who ended up in the periphery?…

Twelve researchers of our Law School have been awarded an ILS seed money grant. This grant enables researchers to create space for preparing a grant proposal for NWO, ERC or otherwise.

Rembrandt painted this Flora, the Roman goddess of spring, in 1635. She is on display above the archway leading from the Academy Building to the lush flora of the University’s Hortus Botanicus. Rembrandt, who had his own cabinet of curiosities, almost certainly knew this botanical garden, the oldest…

This project combines and reconsiders all the available evidence of the Scheurrak SO1, and use new archival databases and modern archaeological techniques to shed new light on the material culture of the Baltic grain trade and the Holland shipbuilding industry at the turn of the sixteenth century.

Discover the impact of Instagram on our daily lives in the book On Display. Boy and Uitermark delve into the platform's influence on our social interactions.

How can we assist Universitas Indonesia's department of International law to improve their educational and applied research programs on Transnational Law, Asset Recovery and International Investment Arbitration, with an eye on Indonesia’s security and rule of law reform agenda and the needs of the…

Resilient Diversity: the Governance of Racial and Religious Plurality in the Dutch Empire, 1600-1800

Extensive research is being conducted at the Institute of Criminal Law and Criminology on developments in sentencing and punitive measures and how judges and other actors in the criminal justice system reach decisions. Another focus area is how punishments and measures are implemented and the effect…

A month ago it was Marc Baggelaar, and now Hans Kistemaker too has obtained his PhD cum laude at the Leiden Institute for Chemistry (LIC). ‘He has made ground-breaking contributions to the world of protein modification,’ says PhD supervisor Gijs van der Marel. Kistemaker obtained his PhD on 11 May…