2,205 search results for “single molecule spectroscopy” in the Public website
-
1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée
-
A new method to reconstruct the structure from crystal images
Promotor: J.P. Abrahams, Co-promotor: T. Grüne
-
High-throughput screening for developmental and reproductive toxicity
Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?
-
Regulation of enzyme production in fungal cell factories
Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.
-
Fungal Chitosans from Fermentation Mycelia for Plant Biostimulants (FunChi)
Our focus is to optimize the fungal cell wall to both increase chitin production and chitin extractability.
-
Functions of autophagy in the filamentous fungus Aspergillus niger
What are the functions of autophagy in the filamentous fungus Aspergillus niger?
-
Gene regulation in embryonic development
The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.
-
Short stay living space in development
Leiden University is developing new short stay living space for foreign guests and employees. De Kloksteeg is currently the last of four projects that has been renovated by the Leiden University Real Estate directorate since 2017. The Service Centre International Staff (SCIS) is responsible for rental…
-
Dissociative chemisorption on transition metal surfaces
The dissociative chemisorption of a molecule on a transition metal surface represents a rate-limiting step in many heterogeneously catalyzed processes, whereby most chemicals are made. In spite of the importance of this reaction, an accurate first principles approach to modeling it does not yet exist.…
-
Chemical Probe Facility
The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…
-
Luis Salome Abarca about plant chemicals and the Hortus botanicus
What chemicals do plants have available, and what happens if they use them when faced with bacteria or fungi? That is what PhD candidate Luis Salomé Abarca is keen to learn. He studies plants’ survival and their use of chemical components in communication and defence. Salomé Abarca works at the Natural…
-
Wolfgang Löffler Lab - Solid State and High Dimensional Quantum Optics
Advancing the understanding of the interaction of light and matter on the single-quantum level is important for near-future quantum technologies but also to answer fundamental questions.
-
The immune system in action against cervical cancer
In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.
-
Flagships
In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.
-
Microbial Sciences
In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.
-
Surface Reactivity of Activated CO2 Selective use of energy in splitting CO2
Juurlink
-
The scent of the universe
Former PhD student Cameron Mackie will been awarded not one, but two dissertation prizes for his thesis on the aromatic universe. His work could provide us with a virtual sniff of space. ‘These molecules in space likely smell like a big charcoal grill!’
-
Reading through proteins with graphene: NWO Vidi grant awarded to Dr. Grégory Schneider
While there are numerous and extremely advanced methods to sequence the genome, only a few methods exist to sequence the proteome. The Vidi project of Grégory Schneider promises to shed light on the most difficult paradigm of proteomics: achieving an error-free determination of the sequence of single…
-
Metabolic and Functional Evaluation of Diabetic Cardiomyopathy using MR Spectroscopy and MR Imaging
PhD defence
-
Research in Physics, Quantum Matter and Optics (MSc)
The master’s specialisation Research in Physics, Quantum Matter and Optics at Leiden University offers a thorough experience on the front line of physics research with a practical training of communicative and computer skills. The programme focuses on Condensed Matter problems, such as Molecular Electronics,…
-
Five Leiden professors elected to KNAW
The Royal Netherlands Academy of Arts and Sciences has elected five Leiden professors from different disciplines as new members. Two of the new members are women.
-
The scientists behind LED3
LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.
-
Using gold particles to make the invisible visible
Gold nanoparticles give us a better understanding of enzymes and other molecules. Biswajit Pradhan, PhD candidate at the Leiden Institute of Physics, uses gold nanorods to study individual molecules that would be challenging to detect otherwise. Resulting knowledge can be applied to many research fields,…
-
Mechanism-based inhibitors and probes for neuraminidases
Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.
-
Accurate modeling of the dynamics of dissociative chemisorption on metal surfaces
Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.
-
Chemically Accurate Simulation of a Prototypical Surface Reaction: H-2 Dissociation on Cu(111)
Methods for accurately computing the interaction of molecules with metal surfaces are critical to understanding and thereby improving heterogeneous catalysis.
-
‘Look beyond your own discipline’
Good research means looking beyond disciplinary boundaries, said Professor of Molecular and Cellular Biochemistry Remus Dame in his inaugural lecture on 10 May. Processes that take place on DNA shouldn’t only be researched in a test tube but also in living cells, for instance.
-
Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
-
Structure-affinity relationships (SARs) and structure-kinetics relationships (SKRs) of Kv11.1 blockers
Source: J Med Chem (2015)
-
A chemical biology approach for targeting of ligand-drug conjugates
Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel
-
Computational approaches to dissociative chemisorption on metals: towards chemical accuracy
We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…
-
Data Science for State-of-the-Art Blood Banking (BloodStart)
There are around 300,000 people in the Netherlands who donate blood on a regular basis. Women can give blood up to three times a year and men up to five times, resulting in approximately one million blood donations each year. Patients that receive this donated blood are already in a vulnerable condition,…
-
Searching for the sibling of the earth
Are there other planets like the earth, and will there also be life? Astronomers study planets around stars other than the sun, with the aim to find out what kind of gasses their atmospheres are made up with.
-
Impaired barrier of inflammatory skin diseases
Focus in skin research
-
A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
-
Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.
-
Reconstruction Methods for Combined HAADF-STEM and EDS Tomography
The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.
-
Superlattices in van der Waals materials: A Low-Energy Electron Microscopy study
n this PhD thesis, the recombination of different atomic lattices in stacked 2D materials such as twisted bilayer graphene is studied. Using the different possibilities of Low-Energy Electron Microscopy (LEEM), the domain forming between the two atomic layers with small differences is studied.
-
Identification of productive and futile encounters in an electron transfer protein complex
PNAS publication on protein encounter complexes
-
Understanding the physical properties that affect the lipid organization in the skin barrier
It is the aim of this project to better understand how the physical properties of lipids influences the structure and overall barrier function of the skin.
-
Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
-
The heart of oxygenic photosynthesis illuminated
Promotor: H.J.M. de Groot, Co-Promotor: A. Alia
-
Making the invisible visible: paramagnetic NMR and the transient protein complex
Promotor: Prof.dr. M. Ubbink
-
Superstructures of lipids and graphene
This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.
-
Fundamental research on the voltammetry of polycrystalline gold
Voltammetry plays a crucial role in modern scientific research by offering valuable insights into the electrochemical properties of materials, with wide-ranging applications in fields such as materials science, energy storage, corrosion studies, and sensor development.
- Vacancies
-
Monitoring and detection of nanomaterials in biological media.
How do nanoparticles bioaccumulate and biodistribute in organisms?
-
Selectivity
Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.
-
New antibiotic named after Leiden
Increasing resistance and a lack of new antibiotics are a serious problem for public health. Against this background, Gilles van Wezel of the Institute of Biology Leiden is looking for new medicines. Together with former PhD student Changsheng Wu and colleagues he discovered the special antibiotic lugdunomycin,…
-
1st Leiden Centre for Interdisciplinary Genome Research meeting
The 1st CIGR meeting was held on March 30, 2021, with talks by representatives of all participating groups.