This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Since the global COVID-19 pandemic, the coronavirus responsible (SARS-CoV-2) has been extensively probed for promising protein targets to establish drug-based therapies.

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

The NET-ROL project builds on the EU's definition of the rule of law to investigate the role of networks in law-making, executive decision-making, and the judiciary. It examines how these networks influence the weakening of the rule of law. Through an interdisciplinary perspective, the project explores…

De positie van kunst en kunstenaars in de westerse samenleving

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

This publication is in Dutch. Please consult the Dutch page.

How do protein modifications work together to repair DNA, and what can we learn about these interactions to better understand disease?

Nu de NAVO inzet op 5% defensiebudget, zoekt Nederland naar financiering. Politicoloog Van der Zwan ziet kansen bij pensioenfondsen—mits defensie duurzaam heet.

Na Shell en Unilever is DSM het derde grote bedrijf dat vertrekt uit Nederland. Fiscalisten zijn niet verbaasd: het sentiment over het vestigingsklimaat hier is momenteel minder gunstig.

De rol van de Eerste Kamer is het toetsen van wetten op uitvoerbaarheid. Wim Voermans, hoogleraar Staatsrecht, zegt voor NPO Radio1 dat de Eerste Kamer nu te veel een politieke rol in plaats van een controlerende rol vervult.

Begin oktober vond de eerste Psychology Connected van dit nieuwe academische jaar weer plaats. Met de vallende herfstbladeren voelen velen zich ook somberder. Onderzoekers delen hoe je een winterdepressie verzacht, en hoe je als ouder het beste kunt omgaan met de depressieve klachten van je kind.

Episode 5 of BOLDcast, the podcast of the Leiden-Delft-Erasmus Centre for BOLD Cities, discusses the evolution of libraries from simple lending points for books to places where people can come together and brush up on their digital skills. The guests in this episode are Frank Huysmans, associate professor…

Marokko zegt het contact met de Duitse regering op. Volgens Marokkaanse media is ministeries en andere overheidsinstanties per brief gevraagd direct de samenwerking op te schorten met de Duitse ambassade in Marokko.

PhD defence

The E.M. Meijers Book Series is the book series published by the E.M. Meijers Institute of the Leiden Law School. The series includes dissertations defended by PhD candidates from the Leiden Law School. Below you will find recent dissertations of team members of the Business & Law Research Network.

Mattias Brand defended his thesis on 10 April 2019

This book examines how Muslim communities in the Netherlands perceive and experience extremism, counter-radicalisation policies, and Islamophobia.

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

PhD defence

Aan de hand van bekende en minder bekende voorbeelden uit de wereld van politiek en media laat dit boek zien hoe je strategisch gebruik én misbruik kunt maken van taal.

Een nieuw boek in de reeks Elementaire deeltjes

Promotores: Arjen Doelman, Jens Rademacher, Max Rietkerk

Doctoral research at Leiden Law School means research at the highest level.

NNMT wordt beschouwd als een nieuw potentieel farmacologisch doelwit in de behandeling van een verscheidenheid van kankers, stofwisselingsziekten en andere pathologieën. Het toenemend aantal publicaties waarin de rol van NNMT bij ziekten wordt opgehelderd, heeft op zijn beurt de ontwikkeling van krachtige…

Below you will find a collection of books, other than those in the BLRN book series, to which members of BLRN have contributed.

While the Netherlands was in lockdown because of the coronavirus, PhD candidate Koen Rijpkema began his research into the same virus. In the lab, he developed molecules that can inhibit an important viral enzyme.

Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.

Subproject of

On 22 June, Anneke Koning defended the thesis 'Return to sender: a multi-method study of guardianship against transnational sexual exploitation of children'. The doctoral research was supervised by Joanne van der Leun, Masja van Meeteren and Johan van Wilsem.

The research group on Diplomacy and Global Affairs studies international diplomacy, international organisation, global, transnational, multi-level and comparative governance.

What are ‘missing links’ in research on teacher professional development trajectories? We focus on the role and development of teacher facilitators in designing and implementing (collaborative) professional development trajectories.

Meet the scientists within the LED3 community

PhD defence

In the master’s programme in Archaeology, you can follow courses on the archaeology of Europe, deepening your understanding of the continent’s long history.

The Life in Custody (LIC) Study comprises a large-scale research project into prison climate and the quality of prison life in Dutch prisons.

Recente publicaties in de Leidse handboekenreeks zullen hieronder verschijnen.

The Institute of Security and Global Affairs (ISGA) in The Hague offers bachelor’s and master’s programmes, minors, and research in security studies, covering cybersecurity, terrorism, diplomacy and contemporary security challenges. Focus keywords: ISGA, bachelor, master, minors, research, security…

A month ago it was Marc Baggelaar, and now Hans Kistemaker too has obtained his PhD cum laude at the Leiden Institute for Chemistry (LIC). ‘He has made ground-breaking contributions to the world of protein modification,’ says PhD supervisor Gijs van der Marel. Kistemaker obtained his PhD on 11 May…

PhD defence

Every year, more than three thousand businesses are declared insolvent in the Netherlands. The purpose of bankruptcy is to divide the assets of these companies among the creditors. However, the value of the claims of the creditors often exceed the value of the assets of the company

The proportion of children who are overweight has increased enormously over the past 20 years. The number has currently stabilised but even so there are still too many overweight and obese children. Could there be some connection with the way they are brought up? Roxanna Camfferman's PhD research shows…

Stay tuned for updates on relevant media appearances of Ellen de Bruijn.

The research group ‘Quantum and Society’ explores the boundary between quantum technology and science communication.

Leids onderzoek naar bestraffing komt tot stand uit verschillende disciplines. Het onderzoeksproject kent een juridische, criminologische, sociaalwetenschappelijke en filosofische invalshoek.