Tycho de Graaf has been appointed Professor of Technology and Private Law at Leiden University as of 1 June 2022.

On Thursday, December 12, 2024, historian and terrorism expert Beatrice de Graaf will deliver the 53rd Huizinga Lecture at the Stadsgehoorzaal in Leiden. Under the title

In 2017 saxophonist Dick de Graaf obtained his PhD degree with his thesis 'Beyond borders : broadening the artistic palette of (composing) improvisers in jazz'. His own views for over forty years on jazz and related styles (amongst other qualities) have lead to the Edison Jazz Oeuvre Prize.

The monthly ILS Lunch Seminars have slowly developed into somewhat of a tradition. During this seminar series, all researchers from Leiden Law School can present their research and apprehend in a comfortable setting what researchers from other research programs and institutes are working on. On Thursday…

Professor Beatrice de Graaf held the 53rd Huizinga Lecture on Thursday 12 December. In front of a a sold-out Stadsgehoorzaal, she spoke about how history can be used in times of crisis to give meaning to the situation.

A recently published article, Productveiligheid en aansprakelijkheid voor AI (Product Safety and Liability for AI), by Gitta Veldt and Tycho de Graaf examines the European Commission’s proposed Artificial Intelligence Regulation.

The James Webb Space Telescope has found evidence of carbon dioxide (CO₂) in the atmosphere of a giant planet 700 light years away. This result provides insight into the composition and formation of this gas giant and shows what James Webb is capable of. The research by the international group of astronomers,…

The research project ‘The History of National Security, 1945-present', is funded by the Netherlands Organisation for Scientific Research (NWO), the Campus The Hague/Leiden University and the Netherlands Institute for Military History (NIMH). The project will run until the summer of 2013, when we hope…

The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.

A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

Key publications of the Predictive Pharmacology group.

Protostars, data science, and the James Webb Space Telescope—Adriaan Janssen’s curiosity knows no bounds. As a double bachelor’s student in Physics and Astronomy, he has truly found his calling, underscored by his nomination for the title of Leiden Science Young Talent 2024.

An overview of research projects at the Predictive Pharmacology group.

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Key publications of the Quantitative Pharmacology group

It is the largest database for space ice yet: The Leiden Ice Database for Astrochemistry: LIDA. Created by astrophysicists at the Leiden Observatory, LIDA includes not only hundreds of measurement data, but also software to examine astronomical observations and prepare new measurements with the James…

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

For a full overview of the publications of the Translational Immuno-Pharmacology group, visit the Google Scholar page.

The course is taught by experts from Leiden University’s Institute of Security and Global Affairs, alongside leading practitioners. Their expertise spans international relations, security policy and counterterrorism, bridging academic insight with real-world experience.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

High-throughput holistic preclinical screens are increasingly used in drug discovery, to assess both drug efficacy and drug safety.

People who are arrested on suspicion of preparing an attack are at risk of becoming radicalised either during or after their detention. Whether or not to arrest someone requires careful consideration. At the end of the prison sentence, it is important to provide effective supervision of the reintegration…

European product safety law is one of the focal points of internal market legislation.

Key publications of the Quantitative Clinical Pharmacology group

What legislative and regulatory questions arise when children, adolescents or elderly people use the Internet?

The project 'Data use, online consumer needs, business strategies and regulatory response' aims to explore and examine the factors that impact upon the efficacy of information disclosure duties pertaining to customer data use in online business.

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

The Hague Journal of Diplomacy (HJD) is the world’s leading research journal for the study of diplomacy and was founded in 2005. The journal is published by Brill.

Who tried to influence the mission and position of the Dutch security services between 1912 and 1992, what effect did that have on the form and contents of the security services? How to account for transformations of the security services?

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Key publications of the Analytical BioSciences and Metabolomics group

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

An important hormone excreting gland in the human body is the pituitary