1,850 search results for “effective drug development” in the Public website
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Soil legacy effects on aboveground plant-insect interactions
In this thesis, the role of plant-mediated soil legacy effects in shaping aboveground plant-insect interactions was investigated.
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Innovation centre for drug development on Bio Science Park
International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.
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Development of novel metabolomics & systems pharmacology concepts to realize personalized medicine
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.
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How do children's kidneys eliminate drugs?
What dose of medicine do you give a child? That depends to a large extent on how quickly their kidneys remove the drug from the blood. For ethical reasons it is impossible to measure this directly in little patients. PhD candidate Sinziana Cristea combined different types of modelling and lots of data…
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Effects of human pressures on aquatic invertebrate
What are interactive effects of human pressures on aquatic communities?
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adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
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Drug Delivery to the Brain
This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB
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Smart chemistry rids anti-cancer drugs of serious side effects
Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…
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Effects of heavy fields on inflationary cosmology
Promotor: Prof.dr. A. Achucarro, Co-Promotor: J.W. van Holten
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Yiran Yang
Faculty Governance and Global Affairs
y.yang@luc.leidenuniv.nl | +31 71 527 5163
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Camila Espinoza Chaparro
Faculteit der Sociale Wetenschappen
c.p.espinoza.chaparro@fsw.leidenuniv.nl | +31 71 527 6718
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Martijn Defilet
Faculteit Archeologie
m.p.defilet@arch.leidenuniv.nl | +31 71 527 2727
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Mi-Lan Woudstra
Faculteit der Sociale Wetenschappen
m.j.woudstra@fsw.leidenuniv.nl | +31 71 527 5439
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Ymke de Bruijn
Faculty Governance and Global Affairs
y.de.bruijn@fgga.leidenuniv.nl | +31 70 800 9503
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David Ehrhardt
Faculty Governance and Global Affairs
d.w.l.ehrhardt@luc.leidenuniv.nl | +31 70 800 9313
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Giulia Callegaro
Science
g.callegaro@lacdr.leidenuniv.nl | +31 71 527 6105
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Marcella Pavias
Faculteit der Sociale Wetenschappen
m.pavias.2@fsw.leidenuniv.nl | +31 71 527 4895
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Specificity and side-effects of mutagenesis by CRISPR/Cas9 -induced breaks in plants
Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?
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Criminal Justice: Legitimacy, Accountability and Effectivity
How can and should tasks and competences for the purpose of the criminal justice system (i.e. legislation, enforcement, the administration of justice and sentencing) be defined and formulated, factoring in the chain concept, adjoining national and international legal domains and standards arising from…
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The LeiCNS-PK3.0 model development and applications: healthy-to-diseased CNS pharmacokinetic translation
Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…
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The rebound effect through industrial ecology’s eyes : the case of transport eco-innovation
Promotor: Prof. dr. Arnold Tukker & Prof. dr. René Kemp (Maastricht University)
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Terrestrial field trials for side-effects of pesticides
The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…
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Anneke Both-de Vries
Faculteit der Sociale Wetenschappen
bothanna@fsw.leidenuniv.nl | +31 71 527 4834
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The effects of stress and fear on nocebo hyperalgesia
What role play stress and fear in forming of nocebo hyperalgesia?
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Development of innovative engineered models for viral diseases
A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…
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Effects of glufosinate-ammonium on off crop vegetation
Description of Effects of glufosinate-ammonium on off crop vegetation.
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Temperature effects on genetic and physiological regulation of adaptive plasticity
Promotor: P.M. Brakefield
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Development of a consistent methodology for assessment of the combined effects of metal-based chemicals to lettuce (Lactuca sativa L.)
How to improve the method in quantifying the combined effects of metal-based chemicals?
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Test development
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Cells with stress: predicting drug-induced liver and kidney damage
How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.
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Conductance and gating effects at sputtered oxide interfaces
This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.
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Linda van Leijenhorst
Faculteit der Sociale Wetenschappen
lleijenhorst@fsw.leidenuniv.nl | +31 71 527 3750
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Stefanie van Esveld
Faculty Governance and Global Affairs
s.van.esveld@fgga.leidenuniv.nl | +31 70 800 9500
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Eduard Klapwijk
Faculteit der Sociale Wetenschappen
e.t.klapwijk@fsw.leidenuniv.nl | +31 71 527 2727
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Harriet Vermeer
Faculteit der Sociale Wetenschappen
vermeer@fsw.leidenuniv.nl | +31 71 527 3491
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Unsprayed field margins: effects on environment, biodiversity and agricultural practice
A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…
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Beyond UN75: A Roadmap for Inclusive, Networked & Effective Global Governance
Drawing on insights from past and contemporary scholars and world leaders, the report explores the concepts of a new social contract, a new global deal, and networked and inclusive multilateralism introduced recently by Secretary-General António Guterres to help the United Nations better grapple with…
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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In vivo tracking and biodistribution of protein aggregates
Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…
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FishForPharma: Training network on zebrafish infection models for pharmaceutical screens
How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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The environmental rebound effect: a new paradigm for an old challenge. The case of transport eco-innovation
What is the role of the rebound effect in achieving environmental savings from transport eco-innovation? Are traditional definitions of the rebound effect adequate in the context of transformative innovations and multidimensional environmental issues?
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Triblock polypept(o)ides for siRNA delivery: unique polymeric designs for versatile carrier systems
Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…
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Towards an ab-axis giant proximity effect using ionic liquid gating
In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.
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Effects of pesticides on aquatic macrofauna in the field
Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver
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Child homicide: Media hype, but no indications for copycat effect
Child homicide is a phenomenon that not infrequently leads to shock and societal unrest. However, the precise nature and scope of child homicide in the Netherlands remains unknown.
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Topic: The placebo and nocebo effects of communication
We study how communication can heal and harm when patients are confronted with an illness. Most of our studies focus on serious illnesses such as advanced cancer. Communication lies at the heart of medicine, yet we do not always know which specific communication helps patients. Moreover, many complaints…
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Establishing State Responsibility in the Absence of Effective Government
On 16 June 2020, Andrea Varga defended her thesis 'Establishing State Responsibility in the Absence of Effective Government'. The doctoral research was supervised by Prof. N.J. Schrijver and Prof. F. Baetens (University of Oslo).