2,614 search results for “development 26 disease” in the Public website
- Week 7-8: 17-26 February 2019
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Systems dermatology of immune-mediated dermatological diseases: cutaneous T-cell lymphoma
The complex pathophysiology of immuno-dermatological disorders is multifactorial, including environmental, skin microbiome, (epi)genetic and immune dysregulation conditions. This project primarily focuses on the orphan disease mycosis fungoides, a subtype of cutaneous T-cell lymphoma. The current pathophysiological…
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Research in Africa reduces health spending and prevents diseases of affluence
Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…
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Endocannabinoids in health and stress
How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?
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Developing new therapies to fight muscle disease
Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…
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Quantitative biology of polar auxin transport and plant development
The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…
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Glucocorticoid modulation of the immune response
Unraveling the immune-suppressive actions of drugs like prednisone.
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Ahmed Mahfouz: 'The mystery of brain diseases, unravelled cell by cell'
Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.
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Modeling interactions to unravel biomarkers for disease progression and treatment response
The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets
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Prediction of human (CNS) target site concentrations in health and disease
Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…
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stable-isotope labeling: exploring neuronal metabolism related to Parkinson’s disease
The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.
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Bram Slütter
Science
b.a.slutter@lacdr.leidenuniv.nl | +31 71 527 6208
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Discovering and developing drugs
Improving healthcare with our scientific discoveries: that is the goal of pharmaceutical research at Leiden University. And there’s a lot involved in that. Our research starts with the discovery of the effect achieved by a particular substance, and sometimes continues all the way through to the development…
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A joint evaluation of local and systemic disease activity in treated-to- target rheumatoid arthritis
PhD defence
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Single gold nanorods in live cells
Visualization of biomolecules in living cells by tagging with gold nanoparticles.
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Glucocorticoids in zebrafish
A novel in vivo model system for studies on glucocorticoid resistance
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Eveline Crone
Faculteit der Sociale Wetenschappen
ecrone@fsw.leidenuniv.nl | +31 71 527 2727
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biology of common and grey seals along the Dutch coast : stranding, disease, rehabilitation and conservation
Promotores: H.A. Udo De Haes, P.M. Brakefield
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Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.
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UM Cure 2020: New therapies for uveal melanoma
Can we bring novel treatment options to the clinic for UM patients with liver metastases?
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Development of new antibiotics from plant-originated products
Utilization of plant-originated products as new antibiotics
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Using zebrafish to target the Achilles’ heel of cancer
Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.
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The role of auxin in somatic embryogenesis
What is the role of auxin in the initiation and process of somatic embryogenesis?
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Macrophage activation and cholesterol accumulation in atherosclerosis development
Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck
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Institute for Chemical Immunology
Overkleeft
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Growth and development of actinomycetes
We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.
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Channeke Keuls
Faculteit der Sociale Wetenschappen
c.s.keuls@fsw.leidenuniv.nl | +31 71 527 2727
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Collaborative and effective drug development
There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…
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The comparative biology of language learning
A theoretical project on the insights gained by human (including infant), nonhuman animal and computational studies on artificial grammar learning; identifying the critical questions for future research by developing novel experimental and computational approaches to address these issues.
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Perception of multidimensional speech sounds in humans and songbirds
Do humans and zebra finches share cognitive mechanisms that are important for speech perception?
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Neurogenomics of vocal learning
How does FoxP1 affect auditory perception on a behavioural and genomic level?
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experts in multilevel bioimaging, analysis and modelling of vertebrate development
How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Thrips resistance in strawberry: more fruits with less pesticides
Can thrips resistance in strawberry be explained based on secondary metabolite profiles and plant morphological traits?
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Roeland Merks
Science
merksrmh@math.leidenuniv.nl | +31 71 527 7106
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Joey Zuijdervelt
Science
j.l.zuijdervelt@lacdr.leidenuniv.nl | +31 71 527 6227
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practice for integrated nursing of the elderly with cardiovascular disease in Sumedang, West Java: towards transcultural nursing in Indonesia
The different kinds of cultural perspectives on health and disease of the participants are related to their knowledge, beliefs, values and practices manifested in various forms of lifestyle in Indonesia. The cultural diversity of the population is also related to differences in health behaviour.
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Breakthrough by Leiden researchers in Pompe disease
Researchers at Leiden University have made a breakthrough in the study of the hereditary Pompe disease. Together with colleagues in York, they have developed a molecule that binds to the enzyme that is key to the progress of the disease. The findings have been published in ACS Central Science.
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Preventing or curing diseases with X-omics
In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…
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Yiran Yang
Faculty Governance and Global Affairs
y.yang@luc.leidenuniv.nl | +31 71 527 5163
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Camila Espinoza Chaparro
Faculteit der Sociale Wetenschappen
c.p.espinoza.chaparro@fsw.leidenuniv.nl | +31 71 527 6718
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Martijn Defilet
Faculteit Archeologie
m.p.defilet@arch.leidenuniv.nl | +31 71 527 2727
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Mi-Lan Woudstra
Faculteit der Sociale Wetenschappen
m.j.woudstra@fsw.leidenuniv.nl | +31 71 527 5439
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Ymke de Bruijn
Faculty Governance and Global Affairs
y.de.bruijn@fgga.leidenuniv.nl | +31 70 800 9503
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David Ehrhardt
Faculty Governance and Global Affairs
d.w.l.ehrhardt@luc.leidenuniv.nl | +31 70 800 9313
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Regulatory networks in Streptomyces
We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.
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Marcella Pavias
Faculteit der Sociale Wetenschappen
m.pavias.2@fsw.leidenuniv.nl | +31 71 527 4895
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Leiden Early Drug Discovery & Development
Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?