3,594 search results for “development 26 disease” in the Public website
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Streptomyces as cell factories
We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.
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Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
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Anneke Both-de Vries
Faculteit der Sociale Wetenschappen
bothanna@fsw.leidenuniv.nl | +31 71 527 4834
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Linda van Leijenhorst
Faculteit der Sociale Wetenschappen
lleijenhorst@fsw.leidenuniv.nl | +31 71 527 3750
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Stefanie van Esveld
Faculty Governance and Global Affairs
s.van.esveld@fgga.leidenuniv.nl | +31 70 800 9500
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Eduard Klapwijk
Faculteit der Sociale Wetenschappen
e.t.klapwijk@fsw.leidenuniv.nl | +31 71 527 2727
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Harriet Vermeer
Faculteit der Sociale Wetenschappen
vermeer@fsw.leidenuniv.nl | +31 71 527 3491
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Development of novel metabolomics & systems pharmacology concepts to realize personalized medicine
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.
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Test development
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ESOF session on vaccines: ‘Infectious diseases know no borders’
How can Europe lead the way in vaccine development that is fast and for all? To answer this pressing question, Professor of Vaccinology Meta Roestenberg is holding a panel session on 14 July at the EuroScience Open Forum in Leiden.
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Why not sing? Reconstructing the evolution of female and male bird song
Female and male songbirds sing equally elaborate songs in some species, but in others, females do not sing like males or not at all. How did such pronounced differences in male and female communication evolve?
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through Configurational and Mechanistic Lenses: Lessons for Concept Development
Valérie Pattyn, Assistant Professor at Leiden University, researched
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New project funded to study Alzheimer's disease
Researchers from Leiden University will develop a new approach to study the biomarkers of Alzeimer’s disease. This approach focusses on the molecular messengers of the cells. The project, led by Thomas Hankemeier and coordinated by Yuliya Shakalisava (Leiden Academic Centre for Drug Research, LACDR),…
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Efficient and flexible platform to isolate and study bacteriophages
We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.
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Development of formulation for treatment of Atopic Eczema
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Fighting diseases with good bacteria
Researchers from the Institute of Biology Leiden have discovered how good intestinal bacteria regulate our innate immune system. This surprising discovery could make it possible to treat diseases related to inflammation, such as diabetes and colitis, with a cocktail of good bacteria. Publication in…
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Susanne Kamerling
Faculty Governance and Global Affairs
s.kamerling@fgga.leidenuniv.nl | +31 70 800 9506
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Caroline Archambault
Faculty Governance and Global Affairs
c.archambault@luc.leidenuniv.nl | +31 70 800 9963
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Leiden: The scene of the Zebrafish Disease Models conference 2018
In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…
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Human disturbance of ecosystems leads to increase in disease-transmitting mosquitoes
The changes that humans are making to the landscape are beneficial for mosquitoes that spread diseases such as Zika, chikungunya and dengue. This is what biologist Maarten Schrama and his colleagues write in the journal Nature Scientific Reports. ‘If we know in which living environments mosquitoes thrive…
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FishForPharma: Training network on zebrafish infection models for pharmaceutical screens
How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?
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Development of organ-on-a-chip systems for translational and personalized medicine
We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.
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Plant ageing, rejuvenation and life history strategy
What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?
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Cultural Anthropology and Development Sociology | Leiden University
Cultural Anthropology and Development Sociology at Leiden University studies the everyday practices of individuals and groups around the world in relation to the complex global challenges of diversity, sustainability, and digitalisation.
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Why arteriosclerosis looks like an autoimmune disease
Arteriosclerosis bears great similarities to autoimmune diseases. Researchers from Leiden University show this in a new study they published in the renowned scientific journal Nature Cardiovascular Research. 'This discovery suggests that treatment methods for autoimmune diseases might also be effective…
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Atherosclerosis resembles an autoimmune disease. Marie Depuydt graduated on this topic, with honours
In addition to cholesterol and high blood pressure as risk factors for atherosclerosis, we may need to address our own immune system to prevent a heart attack or stroke. Marie Depuydt revealed which cells exactly reside in the atherosclerotic plaque that narrows an artery. The presence of a diverse…
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Segments and rules: a comparative study on linguistic rule learning mechanisms
A central and much debated topic in the study of language acquisition concerns the nature of the learning mechanisms that are required. Are the computational and learning mechanisms that guide learning about language structure special and specific to language or humans?
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Analysing diseases through interactive visual interfaces
Alzheimer’s disease and cancer are two examples of diseases that are related to malfunctioning cellular patterns. The examination of cell tissue, however, takes a lot of time and generates a lot of data. To make the analysis of data easier, Antonios Somarakis of the Data Science Research Programme (DSRP)…
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IBL Spotlights - Development & Disease
Lecture
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800 year old mystery of ancient bone disease solved
Scientific research at the molecular level on a collection of medieval skeletons from Norton Priory in Cheshire, United Kingdom, could help rewrite history after revealing they were affected by an unusual ancient form of the bone disorder, Paget’s disease. Osteoarchaeologist Carla Burrell, attached…
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TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge
TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.
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A game of Mastermind to unravel Alzheimer’s disease
In order to better understand the course of Alzheimer’s disease, Frédérique Kok believes that a strategic and structured approach is needed: the Mastermind research approach. With her LUF grant, Kok wants to generate high-quality data to build a mathematical model that can recognize the onset of the…
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Detecting diseases with molecules in the body
Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…
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Zebrafish models for disease and environmental stress
We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.
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Development of personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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Seeking new concepts to treat diseases
Scientific Director of the Leiden Academic Centre for Drug Research (LACDR) Hubertus Irth: ‘We test substances and look for new concepts for treating disease.’
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Advocating for gene therapies for rare diseases
‘If we don’t start talking about this, who else will?’ This is what Arjan Lankester, paediatrician/immunologist at the Leiden University Medical Center (LUMC) and Professor of Paediatrics, thought when it seemed that various extremely effective gene therapies for rare diseases would no longer be available…
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NeCEN
With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…
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Intervention targets in cognitive development
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Cryo-EM of cholera infection
The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?
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Specificity and side-effects of mutagenesis by CRISPR/Cas9 -induced breaks in plants
Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?
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Better understanding of disease thanks to organs-on-chips
For medical research, researchers often recreate tissue in the lab. Organ-on-a-chip technology emulates organs, right down to the blood that flows through them, thus creating a realistic test model for drugs or research into disease processes. Researchers from the LUMC are coordinating an NWO Gravitation…
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Examining teachers’ development during a school innovation: stimulating differentiated student talent development
How do teachers’ knowledge, practices, perceptions, job satisfaction and workload in secondary education develop during a school innovation in the context of differentiated student development?
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Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
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Social Anxiety and Normal Development
Why does social anxiety increase in adolescence and how does it grow out of control in some adolescents?
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Marker assisted breeding for thrips resistance in tomato
Which plant leaf characteristics are involved in thrips resistance in tomato?
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Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
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Development of Comprehensive and High-throughput metabolomics techniques
A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…
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1,2-cis-glycosylations: method development and synthesis of complex oligosaccharides
Promotor: G.A. van der Marel, Co-promotor: D.C. Codée