388 search results for “infections” in the Public website
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Novel immunomodulatory drugs for tuberculosis treatment
Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?
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Molecular Physiology
Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…
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A vaccine against thickened artery walls
Atherosclerosis (thickening of the artery wall) is the most common cause of heart attacks or strokes, and one of the most common causes of death in the western world. People with this condition have to take medicine all their lives, so a vaccine for atherosclerosis would be a breakthrough.
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Workshops & Demo's
During the Leiden Science Family Day, you can take part in various workshops. You can also watch various demonstrations. Where will you go?
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From stress to success: how actinobacteria exploit life without a cell wall
The central question of this Vici proposal is to investigate if, and how actinobacteria exploit life without a cell wall.
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Unfolding the principles of genome folding and dynamics in bacteria
What are the principles of genome folding and dynamics in bacteria?
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Determining the kinetic profile of ENT1 inhibitors
Supervisor: Anna Vlachodimou
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COMMUNITY: unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand
Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Noortje Dannenberg
Science
n.dannenberg@biology.leidenuniv.nl | +31 71 527 5075
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Africa reconsidered
If you follow the western media, you are likely to think of ‘Africa’ as the continent of origin of desperate migrants, a continent of hunger and disease and a breeding ground for international terrorism. But if you want to see the bigger picture, you should look no further than the African Studies scholars…
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Research
The Faculties of Leiden University have developed several themes for research cooperation between Leiden University and its Indonesian partners.
- Publication highlights
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Cancer pathogenesis and therapy
With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…
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Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
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Bioprinting human tissues for drug testing
Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…
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Disrupted movement makes macrophages more lethal to tuberculosis bacteria
Macrophages – the front line of our immune system – protect us from infections. But in the case of the tuberculosis bacteria, this often goes wrong. The group of Annemarie Meijer from the Leiden Institute of Biology has now discovered that macrophages in zebrafish are better able to eliminate tuberculosis…
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Why COVID-19 caused a pandemic (whereas other coronaviruses did not)
Epithelial cells play a crucial role in the lungs. PhD student Ying Wang researched the effects of cigarette smoke and viruses such as COVID-19 on these epithelial cells. ‘We hope to reduce the risk of pandemics in the future.’
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New insights for improved pertussis vaccines - Press release -
Researchers in Bilthoven, The Netherlands, have recently unraveled the defense against whooping cough bacteria in unprecedented detail. The outcome of the project, conducted at Intravacc (Institute for Translational Vaccinology) in Bilthoven, provides opportunities for a new approach in the development…
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Are bacteriophages the new antibiotics?
Bacteriophages, viruses that infect bacteria, may be used as an alternative treatment option when antibiotics fail. Leiden researchers have studied the structure and function of a novel bacteriophage that could be used to treat one of the WHO bacterial strains of concern where new treatments are urgently…
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Malaria researchers from all parts of the world in Leiden
Researchers from all parts of the world will be in Leiden from 2 to 4 May for a major malaria conference. The Leiden University Medical Center (LUMC) is organising a two-day workshop on how vaccines can be tested safely in humans.
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Awards
These honors and distinctions were given to work that was done within the Media Technology program by both students and staff.
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Research
Through our research, we work towards a fundamental understanding of the world and people around us. We use that knowledge to make the world a safe, healthy, sustainable, prosperous and just place.
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Stem cells suppress rejection in organ transplants
Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.
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Leiden University Medical Center
The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.
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Leiden Spinoza and Stevin Prize laureates
Of the 105 Spinoza Prizes that have been awarded since 1995, 26 have gone to researchers from Leiden University. The NWO Spinoza Prize is the highest Dutch award in science. The younger NWO Stevin grant goes to researchers who have achieved great success in the field of knowledge utilisation for society.…
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Research
Research at the BIOSYN group is comprised of the following research themes:
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ZF-HEALTH - Zebrafish Regulomics for Human Health
How can zebrafish research help understanding human diseases?
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Health and disease
Bone research provides plenty of detailed data about the health of a person or a group. This data is not only used to reconstruct the past but also to fight disease today.
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?
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Key publications
Key publications of the Quantitative Pharmacology group
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Institute of Biology
Nature is a never-ending source of inspiration for the researchers at the Institute of Biology Leiden (IBL). Based on a better fundamental understanding of nature, they are able to seek solutions in the area of health and biodiversity. The theme of IBL is ‘Harnessing biodiversity for health.’
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Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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Why Biomedical Sciences at Leiden University?
The Biomedical Sciences Master programme in Leiden will help to deepen and broaden your understanding of human health and disease. We provide you with a challenging and flexible programme in a personalized environment.
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First clinical trial with genetically modified malaria vaccine completed
In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.
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Sugarcoating the search for a new vaccine
A vaccine based on sugar coats does have the potential to combat a multi-resistant staphylococcus. That is what Jeroen Codée and his colleagues from Utrecht state in Nature. In doing so, they are contradicting the earlier conclusions of German colleagues.
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A unique defence: Bacteria lose cell wall in the presence of virus
Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…
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White blood cells in transparent embryos
Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…
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Close contact between women and dogs in prehistoric times
Close contact between women and dogs in prehistoric times Women and dogs were in close contact in the neolithic age of hunters-fishers-gatherers. This has been suggested by Leiden osteoarchaeologist Dr Andrea Waters-Rist and fellow researchers who have studied a tiny biological fossil. The fossil was…
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Statement on ransomware incident at NVIC
In the following statement we would like to inform you of a ransomware incident at the Netherlands-Flemish Institute in Cairo (NVIC) in which your personal information might have been involved. The University of Leiden administrates this institute. Related to the transition to working from home as…
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The immune system: step it up or slow it down?
When foreign matter enters our body, our immune system has to make a choice whether or not to go on the attack. There are times when the system goes wrong, and we end up with an illness or an allergic reaction. Researchers at LUMC are trying to steer the immune system. The dossier on Immunity, Infection…
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Three awarded research projects in NWO-XS call
Cryogenic memories, antibiotic treatment for urinary tract infections and recycling plastic sustainably. These are the subjects of the three NWO-XS grants awarded to Leiden Science researchers.
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New substances inhibit inflammation in the brain
Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…
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Innovative approach to antibiotic resistance
Resistance to antibiotics is a major problem in health care. Thanks to a grant from the Elise Mathilde Fund and the LUF, pharmacologist dr. Coen van Hasselt can look for new dosing schedules to reduce the development of antibiotic resistance.
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Microbial protection of food crops and human health
We investigate bacteria and fungi to understand their malicious or beneficial impact on food crops and their pathogenic or antibiotic role in human health.
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Leiden University Medical Center
In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.
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COVID-19 Library update
Dear library friends,
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Leiden students develop highly contagious card game
Infecting each other with viruses and bacteria while protecting yourself with medicines and vaccinations. Sounds like a fun evening, right? Master students Life Science & Technology Rafael Jezior and Dennis de Beeld certainly think so. Together, they developed ImmunoWars: an exciting card game based…
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Improving nature’s antibiotic
'What nature made isn’t necessarily an optimized medicine to use in the human body,’ says Professor of Biological Chemistry Nathaniel Martin. That’s why a group of Leiden researchers is making a chemistry-based improved version of the frequently used antibiotic vancomycin. They received an NWO NACTAR…
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Combatting antibiotic resistance in a clever way
When you become very good at one thing, that sometimes comes at the expense of something else. Such trade-offs also apply to bacteria. When becoming more resistant to one antibiotic, bacteria can sometimes become more sensitive to another. Linda Aulin, PhD candidate in the pharmacology group of Coen…