562 search results for “targeted therapy” in the Public website
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New imaging technology to assess early drug success
Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Polypept(o)ide-based nanostructures for therapeutic and diagnostic application
Nanoparticles exhibit a number of adjustable properties, e.g., their size, shape, and surface and core chemistry, which can be further diversified with different functional moieties. This opens a broad field for application in diagnostic and therapy. In this respect, the use of a polymeric hybrid material,…
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Philip Spinhoven
Faculteit der Sociale Wetenschappen
spinhoven@fsw.leidenuniv.nl | +31 71 527 2727
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Lioe-Fee de Geus-Oei
Faculteit Geneeskunde
l.f.de_geus-oei@lumc.nl | +31 71 526 9111
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Willem van der Does
Faculteit der Sociale Wetenschappen
vanderdoes@fsw.leidenuniv.nl | +31 71 527 8482
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Oana Georgiana Rus-Oswald
Faculteit der Sociale Wetenschappen
o.g.rus@fsw.leidenuniv.nl | +31 71 527 2727
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Programme structure
The master's specialisation Child and Adolescent Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Preclinical therapy development in FSHD
PhD defence
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Paul Hooykaas
Science
p.j.j.hooykaas@biology.leidenuniv.nl | +31 71 527 4933
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Laura Heitman
Science
l.h.heitman@lacdr.leidenuniv.nl | +31 71 527 4558
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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Unraveling the role of signaling networks controlled by Grainyhead like transcription factor in breast cancer subtypes
This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…
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To target or protect? Militias and political order in African civil wars
Political scientist Corinna Jentzsch received an NWO Veni grant for her research on the conditions of collaboration between militias and state forces and its consequences for safety and political order.
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New zebrafish study to understand human cancer
Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Cool little kids
Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Research
Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…
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Stem cells as cure
Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.
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Programme structure
Courses cover a broad range of relevant subjects and provide in-depth theoretical knowledge as well as training in practical skills and advanced research tools.
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Immuno-photodynamic therapy of cancer
PhD defence
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.
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Analysis of sub-visible particles in complex injectable formulations
Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik
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New professor wants to improve care for sarcoma patients
Doctors should work with patients with bone and soft-tissue tumours to find the best personal treatment strategy says Prof. Michiel den de Sande. He has developed an app that helps choose the right treatment. Van de Sande was appointed Professor of Orthopaedics with a particular focus on paediatric…
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Leiden Index of Depression Sensitivity
The Leiden Index of Depression Sensitivity (LEIDS) measures cognitive reactivity (CR) to sadness, an aspect of cognitive vulnerability to depression, conceptually similar to rumination.
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An online self-help programme for people with HIV and depressive symptoms
To investigate the effectiveness of an online self-help programme for people with HIV and depressive symptoms.
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Why MT3 at Leiden University and the Autonomous University of Barcelona?
The collaboration between Leiden University (Medical Center) and the Autonomous University of Barcelona forms one of the most powerful international alliances for the creation and transmission of knowledge in the field of transfusion medicine.
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Computational modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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Stromal cells suppress immune response symptoms
A new therapy for the serious Graft-versus-Host disease
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Admission and application
Find out how to apply for Transfusion Medicine and Cellular and Tissue Therapies.
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Chemical biology of sphingolipids: fundamental studies and clinical applications
Overkleeft
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Elizabeth (Liesbeth) de Lange
Science
ecmdelange@lacdr.leidenuniv.nl | +31 71 527 6330
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Antithrombotic therapy in the Netherlands- New insights from nationwide data
PhD defence
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Sylvestre Bonnet
Science
bonnet@chem.leidenuniv.nl | +31 71 527 4260
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Strategy
The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.
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Oncode Accelerator
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…
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In vivo tracking and biodistribution of protein aggregates
Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…
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Partners
Our research programme collaborates with all kinds of partners to achieve our goal: bringing scientific discoveries to the clinic as soon as possible.
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Novel regulators of prostate cancer stem cells and tumor aggressiveness
Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm
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Predictive value of semi-physiological models for clearance of renally excreted drugs across the paediatric age range
The kidneys play a major role in the elimination of drugs. In children, the exact age-related physiological changes underlying kidney function remain largely unknown.
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Stefano Coppola Receives AXA RF Fellowship to Study Pancreatic Cancer
Leiden biophysicist Stefano Coppola has received the prestigious AXA Research Fund postdoctoral fellowship. With this grant he can work for two years on a project to research the role of mechanical factors in the development of pancreatic cancer.
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Biologics Formulation
A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…
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GMP facility for innovative drugs (KFT-J10 / IGFL)
The GMP Facility facilitates development and production of Advanced Therapy Medicinal Products (ATMPs) and chemical (peptide) synthesis.
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Career prospects
This Master enables you to practice professional activities such as: lead research projects and develop technically qualified projects in the field of transfusion medicine.
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Rare-earth nanoparticles in bioimaging and therapy
PhD defence
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Chemical biology of glucosylceramide metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?