1,590 search results for “acute and chronic stress” in the Public website
-
Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
-
Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
-
Therapeutic Immunomodulation
The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.
- Transformations in global climate finance
-
A healthy start for all
Many children have an unhealthy diet and do not get enough exercise. Sanne de Vries wants to help everyone get a healthy start in life.
-
Hebben reumapatiënten met hulp van placebotechnieken minder medicatie nodig?
From painful joints to intense fatigue: a third of rheumatism patients suffer serious effects from this chronic condition and rely long-term on medication. Leiden psychologists are to receive a subsidy from the Netherlands Arthritis Foundation to investigate whether placebo techniques can help patients…
-
Why are governments sharing intelligence on the Ukraine war with the public and what are the risks?
In this article, Thomas Maguire, assistant professor at the Institute of Governance and Global Affairs, examines the intelligence of the US, British and Ukrainian governments and NATO partners concerning Russia and its war against Ukraine. This article discusses how and why governments communicate intelligence…
-
Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection
Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.
-
Development of innovative engineered models for viral diseases
A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…
-
Hypermarker
Developing a clinical decision support tool that will make it easier for clinicians to personalise the treatment for patients with high blood pressure. The team is using AI, deep learning methods and patient cohort data from 11 European countries.
-
Cardiovascular Pharmacology
The Cardiovascular Pharmacology research group headed by Ilze Bot aims to elucidate the mechanisms that underlie atherosclerotic plaque destabilization, which is the key process that leads to acute cardiovascular syndromes such as a myocardial infarction or stroke.
-
Social Anxiety and Specific Phobia in Youth
From basic science to real-world interventions
- LED3 Lecture: Designing Modulators of Purinergic Signaling for Chronic Disease Treatment
-
Impact of insect herbivory and microbial inoculants on the rhizosphere microbiome and volatilome
This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…
-
Anxiety and cognitive performance: better insights and new treatments
How does stress influence cognitive performance? What is the role of selective attention to threatening information in this effect? Could we prevent stress-induced decline of cognitive performance with pharmacological interventions? Could we use resting state theta/beta ratio as a biomarker for cognitive…
-
Disentangling drought-responsive traits with focus on Arabidopsis
In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…
-
Clinical Psychology Lab
Psycho-physiological reactions to stress.
-
Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
-
Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
-
Structural characterization of the cell envelope of Actinobacteria under changing environments
Bacteria have the ability to alter their morphology in order to adapt to changing environments.
-
MicroSOS
The MicroSOS project is designed to bring together academic and industrial partners with different expertises to address challenges that agriculture is facing due to climate change and invests in the development of microbiome-based solutions towards more sustainable agricultural practices.
-
THRIVE Study
Towards Health and Resilience in Volatile Environments - People differ in how they are impacted by and respond to stressful experiences. Why is that?
-
Resilience Center Leiden
The Resilience Center Leiden investigates how stress impacts the mental health of young people. For that, the team studies a multitude of factors, such as childhood experiences, the social environment, psychological factors, and neurobiological factors. With this multidimensional approach, we aim to…
-
Pathways - Psychological health and self-management of people with chronic kidney disease
PhD defence
-
Errol Neo
Science
y.y.neo@biology.leidenuniv.nl | +31 71 527 5065
-
Arthur Ram
Science
a.f.j.ram@biology.leidenuniv.nl | +31 71 527 4914
-
Six reasons why it’s hard to lead a healthier life
We know we should do it, and we often want to, but… Why is it so hard to live a healthier life? Professor of Behavioural Interventions in Population Health Marieke Adriaanse explains.
-
Occupational health in the Emergency Department: A study on work-related factors and health/well-being in nurses and doctors in 19 Emergency
Occupational health in the Emergency Department
-
Migraine@Work: work ability in employees with migraine
This study aims to answer two main research questions: (1) What are the main predictors of work ability in employees with migraine? (2) Can we optimise work ability in employees with migraine using a web-based intervention focused on these relevant predictors?
-
Placebo research: Pharmacological conditioning
The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…
-
Bridging the gap, Pelvic floor physical therapy in the treatment of chronic anal fissure
PhD defence
-
Empathic or anxious mistakes?
Empathic or anxious mistakes? A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments
-
Research
The aim of our research program is to better understand the aetiology and course of mood, anxiety and trauma and stressor-related disorders and to test and improve treatments for these disorders.
-
Cognitive and behavioural emotion regulation after negative and traumatic life events
To study relationships between emotion regulation after negative and traumatic life events and psychopathology. Within this context, another goal is to develop and validate emotion regulation questionnaires.
-
REACT Study
The aim of the REACT Study is to examine whether baseline inflammation, and/or neuro-immune responses to stress in a sample of adolescents with experiences of childhood adversity predicts: the perception of stress, social behaviour and general mental and physical health during and after the COVID-19…
-
Development & Disease
Development & Disease is one of the four research themes of the Institute of Biology Leiden.
-
People and Projects
Our team consists of the following members.
-
A sustainable environment
Making public space more sustainable is considered very important in this project. The Humanities Campus will become a pleasant place to spend time, with lots of greenery. Here, people can relax and find coolness on hot summer days.
-
Leiden University Medical Center
The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.
-
Immunotherapy to limit atherosclerosis
Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…
-
Research
The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.
-
Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
-
Transcutaneous vagus nerve stimulation reduces spontaneous but not induced negative thought intrusions in high worriers
Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.
-
The role of the interleukin 12 family in atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager
-
Key publications
Key publications of the Analytical BioSciences and Metabolomics group
-
Liver X receptor: therapeutic targeting of common pathways in Psoriasis and Cardiovascular co-morbidities
Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).
-
Innate immune modulation in atherosclerosis and vascular
Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax
-
Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
-
Carcinogenicity of insulin analogues
Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen
-
The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.