1,393 search results for “treatment” in the Public website
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Efficacy of Self-management training in adolescents and adults with Klinefelter syndrome (XXY)
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“Special Needs by Placebo”: Programme to Advise, Normalize And Control its European Administration (PANACEA)
While many healthcare professionals indicate that they frequently use placebo effects and their mechanisms, there is little formal training on how to deal with placebo and nocebo effects in clinical practice. This project aims to address this gap between scientific knowledge on placebo and nocebo effects…
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Cancer pathogenesis and therapy
With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…
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Control theory methods for quantitative systems pharmacology models
Following their application to system biological models, control theory techniques have further potential to aid in the understanding and application of quantitative systems pharmacology models.
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RE-PAIR: Unravelling the Impact of Emotional Maltreatment on the Developing Brain
What role do parent-child interactions play in the development, maintenance and treatment of depression in young people?
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School non-attendance in students with intellectual disability
Are the types of school non-attendance which have been evidenced in typically developing youth also found among children and adolescents with an intellectual disability (ID)? If so, which types are most prevalent and thus in greatest need of attention, and what factors (child, family, school/environmental)…
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Research projects
An overview of research themes and projects at ABS.
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Topic: Persistent physical symptoms
Persistent somatic symptoms are long term symptoms that lack a clear medical explanation. These symptoms have a high prevalence where most people know someone who experiences such symptoms or they experience such symptoms themselves. Symptoms can vary greatly in and between people. While one person…
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Education
The Clinical Psychology Educational Programme aims to provide specialized knowledge of psychopathology, diagnostic and treatment skills and related scientific research.
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Redemption in the Old Babylonian period: texts, archives, practice
Stephen Moore defended his thesis on 26 May 2020.
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Topic: Work and health
The research connected to this topic is related to Work and health.
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Evaluation of synergistic effects of Chinese herbal medicine and natural compounds on cancers
What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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Severe behavioral and emotional problems, special education and youth care
Which educational and child welfare interventions offer optimal opportunities for positive development to children with severe behavioral and emotional disorders.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Clinical Psychology
Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.
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Brave Steps
A step-by-step approach to building confidence in anxiety-prone young children.
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Resetting the immune system to cure diabetes and rheumatism
In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.
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Jasmina Mačkić delivers a lecture during the Equal Rights Conference ‘Show Your True Colours’
Jasmina Mačkić, assistant professor at the Europa Institute, delivered a lecture about topics related to discrimination during the Equal Rights Conference ‘Show Your True Colours’ in Leiden. The conference was organised by AEGEE-Leiden from the 24th up to an including the 27th of May 2018.
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Influencing your health with your behaviour and thoughts
Psychological processes have a major effect on the course of a disease and the effects of medical treatment. Researchers in the field of Psychoneurobiology examine the interactions between body and mind. They investigate the effects of stress as well as the effect of placebos and nocebos, which can…
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Epilepsy and anxiety: targeting a vicious cycle
How effective is eye movement desensitization and reprocessing therapy in targeting epilepsy-related anxiety?
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Australia
This is an Erasmus+ International Credit Mobility project of the Faculty of Social and Behavoriural Sciences with Macquarie University in Australia.
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PROPER: ‘Near-patient’ prostate cancer models for the assessment of disease prognosis and therapy
How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?
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Oncode Accelerator
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…
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LED3 Drug Discovery Case Studies
To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.
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Stromal cells suppress immune response symptoms
A new therapy for the serious Graft-versus-Host disease
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Metabolomics and Analytics Centre
The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…
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The Hittite Inherited Lexicon
This dissertation attempts to describe the linguistic history of Hittite on the basis of a systematic etymological treatment of its entire inherited lexicon, precisely analyzing the phonological and morphological developments.
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Effects of noninvasive vagus nerve stimulation on perseverative cognition
Can excessive worrying be reduced via stimulation of the vagus nerve?
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Facing your fears together
Peer-mentored cognitive behavioral therapy for adolescents with mild intellectual disability and anxiety disorder
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Programme structure
The master's specialisation Clinical Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.
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Visual analytics for spatially-resolved omics data at single cell resolution: Methods and Applications
The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…
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Special education and autism
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Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Chemical biology of antigen presentation by MHC molecules
MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.
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Are we there yet? Advances in anytime-valid methods for hypothesis testing and prediction
Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…
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Data science for tax administration
In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.
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Chronobiology of depression
What are the circadian disturbances underlying depression vulnerability? How are they related to mood, cognition and sleep ?
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Voila/Neuromet
To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.
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Topic: E-health
The research connected to this topic is related to E-health.
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Systems Pharmacology
The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.
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ACTION
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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Knowledge centre Anxiety & Stress in Youth
Our mission is to recognise and treat stress and anxiety in children as early as possible, by connecting scientific research, clinical practice and education.
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Placebo research: Pharmacological conditioning
The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…
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Inaugural lecture: Innate immunity into the picture
Tuberculosis bacteria and other intracellular pathogens use cells of our immune system as Trojan horses to spread into tissues. Annemarie Meijer, professor of immunobiology, explains how research into innate defence mechanisms using zebrafish inspires novel strategies for infectious disease treatmen…
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Online Course Clinical Kidney, Pancreas and Islet Transplantation
Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.
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Single cell mechanics for disease biology and pharmacology
In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.