2,165 search results for “this week s discoveries” in the Public website
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Predicting early Alzheimer's disease stage in human
A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).
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SysMedPD: Systems Medicine of Mitochondrial Parkinson's Disease
The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Mirjam Sombroek-van Doorm
Faculteit Rechtsgeleerdheid
m.p.sombroek@law.leidenuniv.nl | +31 71 527 2727
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FishForPharma: Training network on zebrafish infection models for pharmaceutical screens
How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?
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Laura Heitman
Science
l.h.heitman@lacdr.leidenuniv.nl | +31 71 527 4558
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Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
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and young alumni provide valuable career tips during Meet the Employer Week
Career Services of the Faculties Governance and Global Affairs, Social Sciences, and Humanities joined forces to organise the ‘Meet the Employer’ Week held from 6 – 10 December 2021!
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Leiden Science through the years
Our Talents and Discoveries is a yearly publication by the Faculty of Science of Leiden University, published since 2003. You can read all the editions online. Note that the original publication was in Dutch; the original title translates as 'What we are proud of'.
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Student life
Your time at Leiden is about more than just studying. Some of your best experiences will stem from being a part of our lively and diverse student community, as well as from life in the beautiful city of Leiden.
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Microbial Sciences
In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.
- Night of Discoveries
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Two-pronged attack on infectious diseases
A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.
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National Meat Free Week: the main reasons to switch to a plant-based diet
National Meat Free Week (Nationale Week Zonder Vlees, 7–13 March) is an initiative to reduce meat consumption. Assistant professor Paul Behrens is studying what impact a change in our food consumption would have on the world. What, according to him, are the main reasons to switch to a (mainly) plant-based…
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Una Europa Discoveries
General Assembly
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Steffen Brünle
Science
s.bruenle@lic.leidenuniv.nl | +31 71 527 4544
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To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…
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Hester Bijl, Rector of Leiden University, to open ENOTE’s first Academic Training Week
The Steering Committee of the European Network on Teaching Excellence (ENOTE) is delighted to announce that Professor Hester Bijl, Rector Magnificus of Leiden University, will deliver the opening remarks for ENOTE’s first Academic Training Week.
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Last Week’s Hype: On the Blackstar album and death of David Bowie
Can David Bowie’s death be seen as a carefully staged hype, just one last version of the musician’s ever-surprising public persona? Cultural Studies researchers Gerlov van Engelenhoven and Bram Ieven look into it.
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Medicinal Chemistry
The mission in this division, headed by Laura Heitman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…
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Novel Chemical Modalities
The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…
- Leiden Loves Science
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
- YAL at Night of Discoveries 2023
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Datini 54th Study Week - Call for Research Papers
The Datini Institute has launched a call for research papers for its 54th Study Week (14-18 May 2023). Deadline for submission: 10 April 2022.
- About this minor
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Warm Sweater Day and Week of Sustainability 2020
Warm Sweater Day, February 7th & Week of Sustainability, February 10th-14th
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Knowledge for the public
Knowledge is everywhere at Leiden University. It is also accessible for those who do not study or work at the University.
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Winner Physics Image Award is Volkskrant Image of the Week
Vera Meester has won the annual Physics Image Award 2016, with her photo of 'smiling' colloids. The Volkskrant published the picture as Image of the Week.
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‘This mentor group will be their new family’
For many a first-year, student life has well and truly begun. This also applies to students in The Hague, who were thrown in at the deep end during the HOP introduction week. We paid them a visit on a sunny afternoon at Landgoed Clingendael.
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About the programme
Drug Discovery and Safety consists of 120 European Credit Transfer System (EC) points.
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Career prospects
In the Master’s programme in Bio-Pharmaceutical Sciences of Leiden University you are trained for a scientific career in drug research and development.
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LED3 Lecture: Molecular glues in drug discovery
Lecture
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Curious Minds
At the Leiden Curious Minds Centre, our research focuses on the relationship of exploratory behaviour and discovery learning to curiosity and the way children regulate their behaviour and emotions. We want to improve our understanding of how children can and do become more and more the captain of their…
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Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
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Plan B for particle physics: finding long lived particles at CERN
This thesis discusses the discovery potential of Intensity Frontier experiments.
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The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
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Structural and functional analysis of proteins involved in natural product biosynthesis and morphological differentiation in Streptomyces
Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.
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European Lead Factory
The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.
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Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor
Promotor: A.P. IJzerman Co-promotor: L.H. Heitman
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Ecology and genomics of Actinobacteria and their specialised metabolism
Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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‘New students, tomorrow's world needs you!
'Today is the start of EL CID, the first of three introduction weeks at Leiden University. A new influx of students is ready and waiting, eager to get started. Vice-Rector Hester Bijl warmly welcomes all new first-years. ‘Go for it and grab your chances!’
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Flagships
In CCLS several subgroups have formed, below you can find an overview of these groups with the names of the leading researchers and a short outline of the project.
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Using AI to improve the Design-Make-Test cycle with Galapagos
Researchers at LED3 are working together with biopharmaceutical company Galapagos to develop software for use in early drug discovery (funded by NWO). This software is able to design molecules with several simultaneously optimized characteristics and will also take prediction reliability into consideration…
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Molecular Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…
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Cell Systems and Drug Safety
The research within the Division of Cell Systems and Drug Safety, headed by Prof. Bob van de Water, is focused on novel therapeutic modalities and novel concepts in early drug discovery, in order to develop more effective and safer therapeutic strategies. We generate advanced cell and computational…
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Luuk van Middelaar launches his new book in London at LSE and UCL
This week, Prof. Luuk van Middelaar (Europa Institute) publishes Alarums & Excursions: improvising Politics on the Europen Stage – a revised update of his 2017 book on the decade of EU crises.