2,539 search results for “modelling ” in the Public website
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Gravitation, strings, and strongly interactive matter
What is the connection between materials with weak and strong gravitational interactions?
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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The speaker in speech – the interdependence of linguistic and indexical information
Which features characterize speakers’ voices, and how are these features determined by what a speaker is saying?
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Causal Discovery from High-Dimensional Data in the Large-Sample Limit
Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets
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Vertebrate automated screening technology (VAST)
How can you use robots and automatic recognition of microscopic images to test the effect of drugs exceptionally quickly?
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Evolution & Biodiversity in Animal Sciences
Animal Sciences’ contributions to the Evolution & Biodiversity research theme include evo-devo research, the evolution of cognitive and behavioural traits, and the evolutionary mechanisms of stress adaptation. This research involves both indoor and outdoor studies.
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Inflammafish: Cross-talk between inflammation and autophagy in tuberculosis
Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.
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Astrochemistry and the Origin of Planetary Systems
Dishoeck
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Diversity in parenting and education
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Anticancer compounds from actinomycetes
How can we find novel natural products from Actinomycetes that act as growth modulators on mammalian cells? Can we harvest and develop the potential of these novel compounds for industrial and medical biotechnology?
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Towards a mechanistic understanding of nanoparticle behavior using zebrafish
The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.
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Residence in Tax Treaties
On Thursday 1 December 2016 at 13.45 hrs, Francisco Sepulveda Ramirez will defend his doctoral thesis ‘Residence in Tax Treaties' at the Academy Building of Leiden University. Supervisor is Professor F.A. Engelen.
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Development & Disease
Development & Disease is one of the four research themes of the Institute of Biology Leiden.
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The Orthodox Church in the Early Modern Middle East: Relations between the Ottoman Central Administration and the Patriarchates of Antioch, Jerusalem
This book bij Hasan Çolak is based on rigorous research on unpublished and unexplored Ottoman correspondence between the Ottoman central administration and the Eastern Patriarchates, published Greek patriarchal documents, and French missionary and diplomatic sources.
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Evolutionary diversification and historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.
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François Mesnard
PhD at Université de Picardie Jules Verne, Amiens - France
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A metabolomics resistance test
Can metabolomic profiling be used to predict resistance against insect herbivores in plants?
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Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
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Enlightening the Primordial Dark Ages
This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.
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Resolving the building blocks of galaxies in space and time
We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.
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The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal
On 16 December 2019, Jan-Harm de Villiers defended his thesis 'The Anthropomorphic Hegemony of Subjectivity: Critical Reflections on Law and the Question of the Animal'. The doctoral research was supervised by Prof. P. Cliteur.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Word order and information structure in Makhuwa-Enahara
This dissertation investigates the grammar of Makhuwa-Enahara, a Bantu language spoken in the north of Mozambique. The information structure is an influential factor in this language, determining the word order and the use of special conjugations known as conjoint and disjoint verb forms.
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Understanding the Heterogeneity of Corporate Entrepreneurship Programs
In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…
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Systems pharmacology of human neuroendocrine disease entities
An important hormone excreting gland in the human body is the pituitary
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Overview
Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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Centre for Digital Heritage (CDH)
The Centre for Digital Heritage undertakes collaborative international research in the field of Digital Heritage. It is an initiative of the University of York.
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How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
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A Critical Discourse Analysis of Incel Violent Extremists and the Stories They Tell
This study is a critical discourse analysis of the misogynistic narratives shared by three incel violent extremists.
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Evolutionary Developmental Biology of Bitterling Fish
We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…
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Revealing the nature of new low-frequency radio source populations
It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.
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RESTORING T-CELL HOMEOSTASIS BY IN VIVO MANIPULATION OF DENDRITIC CELLS
The loss of T-cell homeostasis and tolerance towards self-antigens is the underlying cause of autoimmune and inflammatory diseases like atherosclerosis, rheumatoid arthritis or type I diabetes. Traditionally, the treatment of these diseases consisted on systemic immune suppression, which can entail…
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The early stress response of jasmonic acid in cell suspension cultures of Catharanthus roseus
In order to gain a better insight into the basis of the rapid jasmonic acid (JA)-mediated stress response, an integrated approach using a targeted high-resolution mass spectrometry-based (HRMS) platform, was conducted to monitor the metabolism of JA using the model system of cell suspension cultures…
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A document classifier for medicinal chemistry publications trained on the ChEMBL corpus
Source: J Cheminform, Volume 6, Issue 1 (2014)
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Linking global crop and livestock consumption to local production hotspots
International trade plays a critical role in global food security, with global consumption having highly localized environmental impacts.
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Evolution and development of orchid flowers and fruits
To gain more insight into the evolutionary development of orchid flowers and fruits, the orchid species Erycina pusilla was studied. The evolutionary origin of the median petaloid sepal, the callus on the labellum, and the stelidia was studied.
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Shape Analysis for Phenotype Characterisation from High-throughput Imaging
We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.
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Morphodynamic equilibria in tidal inlet systems: sensitivity to geometrical variations
A tidal basin is an inland sea which is almost entirely enclosed by land and connected to the open sea by a tidal inlet. Through the tidal inlets interaction takes place between the tidal basin and the open sea.
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Going global to local: achieving agri-food sustainability from a spatially explicit input-output analysis perspective
The global agri-food system plays a critical role in food security and environmental issues.
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Science based business
The mission of science based business (SBB) connects the domains of science, business, and policy. Scientific research we focus on at Leiden in areas such as artificial intelligence promises to reshape our societies for the better. Translating science into positive societal impact however requires new…
- Russian Post-Soviet Diplomacy
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Laminar Technology and the Onset of the Upper Paleolithic in the Altai, Siberia
The Altai region has yielded a cluster of Middle and Upper Paleolithic stratified sites that have been recently excavated using a multidisciplinary approach.
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Digital Archaeology
Digital Archaeology is concerned with digital data for for archaeological research, and the computational methods and tools required to collect, analyse and manage it.
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Substances from Cradle to Grave
Materials balances have been used in the recent past for the analysis of substance oriented environmental problems and the formulation of measures for environmental policy. In this study an integrated tool, based on the materials balance principle, has been developed for the analysis of both environmental…
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Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)
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Explaining Contestation: Votes in the Council of the European Union
The researchers examine the Council of the European Union's voting behaviour between 2010 and 2021 and the impact of different independent variables.
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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The role of ceramide chain length distribution on the barrier properties of the skin lipid membranes
The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…