2,673 search results for “development 26 disease” in the Public website
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Unspinning chromatin: molecular mechanisms of chromatin remodeling
How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?
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Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands
Supervisor: Andrea Martella
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The Netherlands X-omics Initiative
The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.
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A much-needed new class of antibiotics
Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…
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Single cell technologies for mechanobiology and mechanopharmacology
Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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Kinetics for drug discovery – The first step towards an improved drug discovery paradigm
Supervisor: Indira Nederpelt
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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European Energy, Environment and Health
Research on this theme addresses the systemic risks faced by European societies and affecting the quality of life of European citizens.
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Unraveling temporal processes using probabilistic graphical models
Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.
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From data to models: reducing uncertainty in benefit risk assessment: application to chronic iron overload in children
M. Danhof, Co-promotor: O.E. Della Pasqua
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Outreach
The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
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Utopia: Universal Three-dimensiOnal Passport for process Individualization in Agriculture
Agricultural foods naturally vary in their detailed internal structure. To facilitate early detection of health hazards due to contamination or disease, predict maturity and minimize wastage, it is critical to take into account the internal characteristics of each individual product, as these enable…
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Medicine/Leiden University Medical Center
We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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Impact and city
Leiden University and the city of The Hague are working closely together to increase the impact of our research and education in order to contribute as much as possible to the development of the city.
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Bioactive Molecules in Microbial Sciences
Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.
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Transcultural Health Care Utilisation in Serengeti of Tanzania: Towards Applied Ethnoscience in Public Health Management
The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.
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Institutes
All research at Leiden University is organised into institutes. To do justice to the wide spectrum of research (and consequently teaching) that comes from these, you will find descriptions of all the Leiden institutes on these pages.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Grant: Dr. Amanda Foks receives a prestigious Junior Postdoc fellowship from the Dr. E. Dekker stipendium awarded by the Dutch Heart Foundation
Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.
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Cancer Drug Target Discovery
In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…
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We all BENEFIT: The Ecosystem for Healthy Living
The modification of risk factors and related health behaviors lies at the very core of adequate cardiovascular risk management, yet evidence shows that the majority of people with cardiovascular disease (CVD) fail to achieve a healthy lifestyle in the long term. The main objective of this project is…
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e-Coach: Tailored cognitive-behavioral e-Health care for patients with chronic somatic conditions
The major aim is to develop, evaluate, and implement disease-generic cognitive-behavioral interventions through the internet in order to optimize tailored health care for patients with chronic somatic conditions.
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Advanced MRI-markers of cerebral small vessel disease
PhD defence
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Multifaceted role of the complement system in health and disease
PhD defence
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Early diagnosis and management of celiac disease in childhood
PhD defence
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4D-Flow MRI of Aortic and Valvular Disease
PhD defence
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Genetics and Life Course Epidemiology of Cardiometabolic Disease
PhD defence
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Atherosclerotic cardiovascular disease: Interplay between sex, age, and circadian rhythms
PhD defence
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Viral gene therapy approaches for CRB1 retinal disease
PhD defence
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Pharmacotherapy and Ventilatory Control in Health and Disease
PhD defence
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Role of intestinal microbiota in cardio-metabolic disease
PhD defence
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Oxidants and antioxidants as targets for cardiovascular disease prevention
PhD defence
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Developmental cell lineage dynamics in Bicuspid Aortic Valve disease
PhD defence
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Disentangling the relationship between depression, obesity and cardiometabolic disease
PhD defence
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Call for Contributions: Third conference of the Law and Development Research Network
From 19 to 21 September 2018 the third annual conference of the Law and Development Research Network (LDRN) will take place at Leiden University. The theme of the conference will be 'Interfaces'.
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Taking a closer look at resistance to tuberculosis bacteria
Though tuberculosis can be cured today, new resistant strains of the bacteria are becoming a growing problem in the medical world. Biologist Annemarie Meijer and her colleagues are studying resistance to this disease. Their research is already yielding several interesting clues that could help the development…
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Leiden University and ICTU start research on software development
How can we further streamline the development of software for the government? Leiden University and ICTU are to investigate this in a joint research project that was launched on 6 July 2016.
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On imagination in science: ‘A good researcher is also an inventor’
As far as Daniël Pijnappels, Professor of Cellular Electrophysiology, is concerned, both researching and inventing are essential for a scientist.
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Minor Sustainable Development
Make a difference! Join the interdisciplinary Minor Sustainable Development and learn everything about the challenges we are facing and how to find solutions. Discover your sustainable future!
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Contact
Contact details
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Unveiling dark structures with accurate weak lensing
Improvements of weak gravitational lensing shape measurements are presented and some used for data analysis.
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Walk-in concert University organ
Arts and culture
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Van Aanvallen! naar verdedigen? De opstelling van Nederland ten aanzien van Europese integratie, 1945-2015
To what extent did The Netherlands' attitude towards European integration change after the 2005 referendum on the European Constitution?
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The People in Between: Education, Desire, and South Koreans in Contemporary China
Xiao Ma defended her thesis on 26 September 2018
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Theoretical Physics
Leiden has a strong tradition in theoretical physics, thoroughly linked with experimental disciplines.