967 search results for “complex systems” in the Public website
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Cytochrome P450 3A-mediated first-pass and systemic drug metabolism in children
From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.
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personalized health monitoring using ultra-weak photon emission based on systems medicine concepts
Promotor: Jan van der Greef; Co-promotors: Mei Wang; Eduard van Wijk
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glucocorticoid and mineralocorticoid receptor signaling in the innate immune system
Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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sentencing: a homicide case flow analysis of the Dutch criminal justice system
Homicide engenders broad moral concerns in society, and its aftermath can be understood as a barometer for criminal justice policy. Of all homicides committed, however, only some lead to arrest, to prosecution and ultimately to conviction in court.
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Frank Takes
Science
f.w.takes@liacs.leidenuniv.nl | +31 71 527 7143
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Akrati Saxena
Science
a.saxena@liacs.leidenuniv.nl | +31 71 527 2727
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Joram van Ketel
Faculteit Rechtsgeleerdheid
j.e.van.ketel@law.leidenuniv.nl | +31 71 527 7536
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Sebastian Fajardo Bernal
Science
s.d.fajardo.bernal@liacs.leidenuniv.nl | +31 71 527 2727
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Scientific understanding and provision of an enhanced and robust monitoring system for Responsible Research & Innovation (RRI)
Across Europe, the need for a more dynamic governance and a better societal integration of research and innovation is increasingly appreciated. Internal drivers of change (such as the digitalization of science) and political will to better align with societal needs and concerns are bringing about aspirational…
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System-level design for efficient execution of CNNs at the edge
A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.
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Measuring sustainability: an elaboration and application of the system of environmental-economic accounting for Indonesia
Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…
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Development of novel metabolomics & systems pharmacology concepts to realize personalized medicine
The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.
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A joint evaluation of local and systemic disease activity in treated-to- target rheumatoid arthritis
PhD defence
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Nanoparticle-based combination drug delivery systems for effective cancer treatment
PhD defence
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Myfel Paluga
Faculteit der Sociale Wetenschappen
m.d.paluga@fsw.leidenuniv.nl | +31 71 527 3451
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Why do birds flock? Shedding light on collective motions in heterogeneous populations
Leiden physicists Alexandre Morin and Samadarshi Maity study self-organisation and flocking phenomena. They shed light on flocking, which helps to understand how it is possible that birds in a flock don't collide. With plastic microbeads, they create an experimental setup and they developed a mathematical…
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Dynamics of the renin-angiotensin aldosterone system in dogs: circadian variations in physiological conditions and in relation to angiotensin-converting
Promotor: Prof.dr. M. Danhof
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Revealing the origins of solar systems: examining the formation of proto-planetary disks and binary stars
What is the origin of solar systems?
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and Cosmetic (MAC) Plants in the Utilisation of the Plural Medical System in Pirgos and Praitoria for Community Health Development in Rural Crete
Promotor: Prof.dr. L.J. Slikkerveer
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Material flow analysis for the C&D waste management systems in the Netherlands, Belgium, Spain and Finland
What are the flows of C&DW (e.g. bricks, concrete, gypsum and wood) in the case study countries ? How to define the specification for each material to be quantified? What indicators should be used to identify the pattern of each C&DW management system? How to interpret the MFA results in relation…
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the study of physics: An investigation of physics teachers' belief systems about teaching and learning physics
This doctoral thesis comprises four studies on the content and structure of physics teachers’ belief systems about teaching and learning physics in secondary education in the Netherlands.
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Handbook of Signal Processing Systems
Handbook of Signal Processing Systems is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications;…
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engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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tanks in a consensus – seeking and neo-corporatist policy advisory system
Bert Fraussen and Valérie Pattyn theoretically contribute to the existing literature on policy advice by drawing inspiration from niche theory.
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Systems microscopy to unravel cellular stress response signalling in drug induced liver injury
Promotor: B. van de Water
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The intergenerational transmission of an extreme belief systems: Theoretical exploration of a new field of study
With the recent rise and fall of IS, academics and policy makers around the world are expressing concerns about the fate of children of former foreign fighters. Will they follow in their parents’ footsteps? In this paper, Layla van Wieringen, Daan Weggemans and Marieke Liem argue that in light of this…
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Exploration on and of Networks
This dissertation consists of two parts, with the common theme
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Pharmacometabolomics; prediction of system-wide multi-biomarker drug response
The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.
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Constructing elliptic curves of prescribed order
Promotor: Peter Stevenhagen
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.
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characterization of plant exudates and their correlation with plant defense systems
Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
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β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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The spin evolution of accreting and radio pulsars in binary systems
Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.
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More than a digital system: how AI is changing the role of bureaucrats in different organizational contexts
In this paper, Sarah Giest and Bram Klievink highlight the effects of AI implementation on public sector innovation. This is explored by asking how AI-driven technologies in public decision-making in different organizational contexts impacts innovation in the role definition of bureaucrats.
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modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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Tiny clumps recycle themselves into complex structures
Manufacturers produce high-end technology mostly top-down with large machinery, but small particles are able to build structures by themselves from the bottom up. A major challenge is that these particles easily clump together. Leiden physicist Daniela Kraft has developed a method to use this phenomenon…
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Shielding software systems: A comparison of security by design and privacy by design based on a systematic literature review
The authors systematically search and review relevant definitions of Security by Design (SbD) in comparison with Privacy by Design (PbD).
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Berent Baris
Science
b.t.baris@cml.leidenuniv.nl | +31 71 527 2727
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José Mogollón
Science
j.m.mogollon@cml.leidenuniv.nl | +31 71 527 7166
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Willem Meilink
Science
w.r.m.meilink@biology.leidenuniv.nl | +31 71 527 4882
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Xinpeng Jin
Science
x.jin@cml.leidenuniv.nl | +31 71 527 2727
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Anke van der Hoeven
Faculteit Rechtsgeleerdheid
a.m.h.van.der.hoeven@law.leidenuniv.nl | +31 71 527 2727
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Roosje Peeters
Faculty of Humanities
r.m.m.peeters@hum.leidenuniv.nl | +31 71 527 2699
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Arko Ghosh
Faculteit der Sociale Wetenschappen
a.ghosh@fsw.leidenuniv.nl | +31 71 527 5123
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The immune system: step it up or slow it down?
When foreign matter enters our body, our immune system has to make a choice whether or not to go on the attack. There are times when the system goes wrong, and we end up with an illness or an allergic reaction. Researchers at LUMC are trying to steer the immune system. The dossier on Immunity, Infection…