2,220 search results for “war on drugs” in the Public website
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NMR structural studies of protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Images of the Indonesian War of Independence, 1945-1949 - Online Exhibition
Starting January 18, the online exhibition Images of the Indonesian War of Independence, 1945-1949 can be viewed via the UBL website. The exhibition is the result of a collaboration between the Royal Netherlands Institute of Southeast Asian and Caribbean Studies (KITLV) and Leiden University Libraries…
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Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Fighting in God’s Name
This book underscores the interplay between religion and politics (local and global) in the production, escalation, management, mitigation, and resolution of conflict.
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War in Europe
Conference
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Lecture Adam Zamoyski - What were the Napoleonic Wars really about?
On 27 september historian Adam Zamoyski held a captivating lecture on his new book Napoleon: the Man behind the Myth. During this lecture, which was an initiative by Polen in Beeld and the Central and Eastern European Studies Center, Zamoyski answered the question: ‘what were the Napoleonic Wars really…
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Marieke Liem in The Economist on drug-related murders in Europe
Marieke Liem, professor at ISGA, discusses how the number of drug-related murders has not decreased in the last years
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Paul Christiaan Flu: a Surinamese professor in a time of war
Paul Christiaan Flu, originally from Surinam, was a brilliant tropical doctor, who in 1938 rose to the position of Rector Magnificus of Leiden University. The war years brought his lightning career to an abrupt end: his son was murdered and he himself was imprisoned in a concentration camp. A sad family…
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The role of glomerular filtration and active tubular secretion in predicting renal clearance in children using population pharmacokinetic and
In this thesis population pharmacokinetic and physiologically-based pharmacokinetic (PBPK) approaches were applied to investigate the influence of glomerular filtration (GF) and active tubular secretion (ATS) on renal clearance in children.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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Queen Máxima inspects zebrafish embryos
On Wednesday the 4th of September, Queen Máxima opened the renovated tropical greenhouse complex of the Leiden Hortus Botanicus. At the occasion Máxima met with IBL-PhD student Mahin Ghorbani from Iran and talked with her about her work on drug discovery from Iranian medicinal plants using zebrafish…
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Alumnus Robert Ietswaart: ‘Machine learning is revolutionising drug discovery’
Robert Ietswaart does research into gene regulation at the famous Harvard Medical School in Boston. He developed an algorithm to better predict whether a candidate medicine is going to produce side effects. He studied mathematics and physics in Leiden, and gained his PhD in computational biology in…
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LUF grant to take the war out of children
Sandy Overgaauw has been awarded a 25,000 euro grant from the LUF for her research into PTSD in Syrian refugee children in the Netherlands. The research should lead to a screening method that can be used to determine which children are at higher risk of developing posttraumatic stress disorder (PTSD…
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A hornets’ nest: Leiden University during the Second World War
‘That hornets’ nest in Leiden must be destroyed,’ said Dutch National Socialist Party member Robert van Genechten in November 1942. He was referring to Leiden University. Why this hatred? Emeritus Professor of University History Willem Otterspeer has written a book about Leiden University during the…
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Fighting cancer with light (and a drug that self-assembles into nanoparticles)
Chemotherapy that does not harm the body, but effectively fights cancer cells: that is the goal of chemist Sylvestre Bonnet and his team. During his PhD research, chemist Xuequan Zhou brought that goal a little closer. He developed molecules that, upon injection in the bloodstream, self-assemble into…
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Using AI to Combat Drug Resistance - an Interview with PhD student Rosan Kuin
Rosan Kuin started her PhD in July at the LACDR under supervision of prof. Gerard van Westen and Dr. Meindert Lamers. She completed a BSc. in Pharmaceutical Sciences at the VU University in Amsterdam in 2017. After that she started two master programs, Drug Discovery & Safety with a specialization in…
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LUMC involved in development of novel drugs to treat and prevent SARS-CoV-2 and other coronaviruses
The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…
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In war crimes, commanders do not have legal immunity
In her capacity as a lawyer and expert in International Humanitarian Law and Human Rights, Professor Helen Duffy is filing a lawsuit against the Dutch State. Leiden University’s weekly newspaper Mare reports that through her role, Duffy is assisting a Palestinian Dutchman whose family was killed in…
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Ovalbumin coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice
The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…
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The state of research on terrorism
During the 1980s and early 2000s, authors like Alex Schmid and Andrew Silke demonstrated the paucity of first-hand insights being used to study terrorism and the consequences this had for the reliability of the findings beings presented. But to what extent have these issues endured?
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In the media and research
Below you will find an overview of how researchers from the Faculty of Governance and Global Affairs and their research appear in the media, and you can read more about topics that concern the Faculty.
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Experts on the war in Ukraine, two years later: ‘Europe learned a lot from the war, help each other and don’t give up’
The one-day symposium ‘War in Europe: the impact of Russian aggression in Ukraine two years on’ on 23 February 2024
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Facing the enemy
How were war heroes and war criminals created, and how do these images relate to the historical context?
- Vacancies
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Research projects
An overview of research projects at the Predictive Pharmacology group.
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Events
One of LUCIR’s key objectives is to bring together scholars and students of International Relations. To this end, LUCIR regularly organises events such as conferences, roundtables, lectures and book launches.
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Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
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Project TARGET: gun violence and firearms trafficking in Europe”
Project TARGET aims to improve our understanding of gun violence in Europe and the relationship between gun violence and firearms trafficking.
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Light-activatable metallodrugs and metal-functionalized liposomes
Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…
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COVID-19 Research and Education at Leiden Academic Centre for Drug Research
Since the start of the Corona crisis, several COVID-19 related research and teaching projects were started at LACDR. The computational and teaching activities started right away, as well as a large-scale metabolomics screening program by Thomas Hankemeier’s group. Other experimental activities are still…
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Unlocking Nature’s Pharmacy from Bogland Species
Development of Natural Resource for New Medicines
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Programme structure
This one-year, English-taught Master's programme offers insights on general developments as well as the specific challenges in the field of the governance of crisis and security, with in-depth knowledge of sub-fields of crisis and security management.
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Smart chemistry rids anti-cancer drugs of serious side effects
Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…
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FishForPharma: Training network on zebrafish infection models for pharmaceutical screens
How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Governance and Global Affairs
Knowledge that benefits society is the domain of the Faculty of Governance and Global Affairs (FGGA). FGGA provides high-quality interdisciplinary education on and research into social and governance issues such as terrorism, organisation of public administration, climate change and economic crises.
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From socialism via anti-imperialism to nationalism
This dissertation explores how domestic political power struggles in Greece and Turkey during the Cold War engaged with the ongoing conflict in Cyprus and aims to demonstrate how socialist parties in Greece and Turkey struggled with the concept of the “nation” in battling for power and political positioning…
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Moritz Jesse on migration and peace in post-war Europe
Dr Moritz Jesse (Associate Professor at the Department of European Law) was invited to present a lecture on the role of migration on peace and stability in post-war Europe at a masterclass for students and staff at the Catholic University of Lille, France. The talk, which bore the title ‘People’s mobility…