This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Since the global COVID-19 pandemic, the coronavirus responsible (SARS-CoV-2) has been extensively probed for promising protein targets to establish drug-based therapies.

This thesis focuses on developing new chemical synthesis strategies to produce native ADP‑ribosylated biomolecules with precise structural control.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

How do protein modifications work together to repair DNA, and what can we learn about these interactions to better understand disease?

Els Rose has received an honorary doctorate from the University of Lausanne. Rose is professor of late and medieval Latin at Utrecht University. The committee commended Rose for “ her original research, that has contributed to an understanding of the breadth and depth of the reception of texts and traditions…

Dr. Cecily Rose, Associate Professor at the Grotius Centre for International Legal Studies, has appointed by the Dutch Government to the Advisory Committee on Public International Law, with effect as of 1 January 2025.

The monthly ILS Lunch seminars bring together colleagues and students from Leiden Law School, providing an informal setting to hear what researchers from other research programs and institutes are working on. On Thursday 12 December 2019, the final ILS Lunch Seminar of this year takes place. This month,…

On 30 November 2016, Cecily Rose participated in a Symposium held at the T.M.C. Asser Institute on 'A Court for the World? Trust in the ICJ 50 years after South West Africa'.

The Register of Early Modernists aims to facilitate collaboration between early modern researchers at Leiden University.

A team of researchers at Leiden University is collecting information about the methods used by researchers in the field of public international law. The research team consists of Cecily Rose, Misha Plagis, Johanna Trittenbach, and Nicholas McGuire. The goal of this research project is to understand…

The book is written for students working in a range of disciplines, and provides an accessible, balanced and nuanced introduction to the field of public international law. It explains the basic concepts and legal frameworks of public international law while acknowledging the field’s inherent complexities…

Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.

Join-in courses zijn MA-cursussen over middeleeuwse onderwerpen gegeven binnen vastgestelde MA-programma's van de zes deelnemende universiteiten van de Onderzoekschool. Op aanvraag zijn deze vakken toegankelijk voor studenten van andere (Nederlandse) universiteiten. De cursusbelasting en het aantal…

The historical archaeology of the Port of Sandy Point and its anchorage, St. Kitts, West Indies

This commentary on the United Nations Convention Against Corruption discusses each provision of the treaty, traces the provisions’ drafting history, and explores their implementation in domestic legal systems.

On 17 August 1945, two days after the Japanese surrender that also brought an end to the Second World War in Asia, Indonesia declared its independence. The declaration was not recognized by the Netherlands, which resorted to force in its attempt to take control of the inevitable process of decolonization.…

The Common Market Law Review has an internationally composed Editorial Board and Advisory Board.

Research at the Grotius Centre for International Legal Studies is primarily carried out under its Research Programme ‘Exploring the Frontiers of International Law’.

The Grotius Centre Working Paper Series is an occasional series through which researchers in the Grotius Centre can publish the unedited versions of manuscripts that have been accepted for publication by journals and books.

Meet the scientists within the LED3 community

FluidKnowledge will investigate the past, present and future of evaluating ocean science. Regarding the past, it will ask how research priorities in ocean science evolved until now. Which lines of inquiry became hot topics, and which died out? Who became global players, who ended up in the periphery?…

Twelve researchers of our Law School have been awarded an ILS seed money grant. This grant enables researchers to create space for preparing a grant proposal for NWO, ERC or otherwise.

Rembrandt painted this Flora, the Roman goddess of spring, in 1635. She is on display above the archway leading from the Academy Building to the lush flora of the University’s Hortus Botanicus. Rembrandt, who had his own cabinet of curiosities, almost certainly knew this botanical garden, the oldest…

This project combines and reconsiders all the available evidence of the Scheurrak SO1, and use new archival databases and modern archaeological techniques to shed new light on the material culture of the Baltic grain trade and the Holland shipbuilding industry at the turn of the sixteenth century.

Discover the impact of Instagram on our daily lives in the book On Display. Boy and Uitermark delve into the platform's influence on our social interactions.

How can we assist Universitas Indonesia's department of International law to improve their educational and applied research programs on Transnational Law, Asset Recovery and International Investment Arbitration, with an eye on Indonesia’s security and rule of law reform agenda and the needs of the…

Resilient Diversity: the Governance of Racial and Religious Plurality in the Dutch Empire, 1600-1800

Extensive research is being conducted at the Institute of Criminal Law and Criminology on developments in sentencing and punitive measures and how judges and other actors in the criminal justice system reach decisions. Another focus area is how punishments and measures are implemented and the effect…

Nicolaes Tulp (1593-1674) studied medicine in Leiden. He attended lectures in the Academy Building and was taught anatomy in the former Faliede Begijn church, now the ‘Old Library’ (Oude UB) building, for a long time the location of the anatomical theatre. Shortly after his move from Leiden to Amsterdam,…

Grammatical gender is famously the most puzzling of the grammatical categories. We have a solid typology of gender systems, yet exciting and unexpected patterns keep turning up which defy easy classification and straightforward analysis. Some of these question, stretch or threaten to cross the outer…

The project 'Policing the high seas: maritime law-enforcement in a multi-actor environment' aims to identify the gaps in the legal framework for EU activities in the maritime security domain, and specifically in the areas of combating piracy, human smuggling or trafficking and drug trafficking.

Taught by top researchers from a wide range of disciplines, the MA Chinese Studies at Leiden University combines in-depth knowledge with advanced language proficiency with a year-long stay in China.

Brian McGarry and Cecily Rose, both affiliated with the Grotius Centre, are members of an adjudicative body established under the auspices of the NATO Support and Procurement Agency (NSPA). NSPA is ‘NATO’s lead organization for multinational acquisition, support and sustainment’ for the 32 NATO nations,…

Aleydis Nissen, one of our colleagues from Belgium, created a feature article with photos for Knack magazine (Roularta Media Group). The Pascal Decroos Fund sponsored this article.

The VICI research project Citizenship Discourses in the Early Middle Ages, led by Els Rose (Universiteit Utrecht), published a new book: Els Rose, Robert Flierman en Merel de Bruin-van de Beek, red., City, Citizen, Citizenship, 400–1500. A Comparative Approach (Londen: Palgrave-Macmillan, 2024). It…

On this page you will find an overview of awards and prizes granted to our staff and students in 2023, as well as special appointments at Leiden University and other institutions.