16 search results for “pharmacology” in the Public website
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Founding father of pharmacological models
After 41 years, Meindert Danhof, Professor of Pharmacology, is leaving the Leiden Academic Centre for Drug Research on 31 March. A symposium in his honour, prior to his farewell lecture, will show what has been achieved in this period. Danhof takes a look back on his career.
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Metabolomics Facility
The Metabolomics Facility of the University of Leiden has brought together two research groups from the Faculty of Science that are well-known for their expertise in two different fields: the Biomedical Metabolomics Facility Leiden, experts in clinical metabolomics and the Natural Products Laboratory,…
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Pharmacy in Leiden #21 in QS ranking 2016
This year, the Leiden Academic Centre for Drug Research ranks #21 in the QS World University Rankings by Subject. With this, the institute ranks as the best in The Netherlands for the subject Pharmacy.
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Virtual children help prevent withdrawal syndrome in real children
When children wean off from heavy medication, they often experience withdrawal symptoms. The severity of these symptoms is often difficult to predict. Pharmacologist Bas Goulooze developed a computer model to determine the best weaning strategy for each child. His research has now been published in…
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Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…
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Liesbeth de Lange wins Lewis B. Sheiner Career Prize
Pharmacologist Liesbeth de Lange has won the Lewis B. Sheiner Lecturer Award from the International Society of Pharmacometrics (ISoP). As Professor of Predictive Pharmacology she is working, among other things, on a mathematical model that can predict drug concentrations in the brain. On the occasion…
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Innovation centre for drug development on Bio Science Park
International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.
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Medicine development is hunting magic bullets
Medicines are becoming increasingly precise and innovative, but at the same time increasingly expensive. With their innovations, it is up to universities to increase competition, thus causing prices to drop. This is what newly appointed Professor of Biomolecular Analysis Hubertus Irth argues. His inaugural…
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Drug Delivery to the Brain
This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB
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Improving painkiller dosing in the clinic
Children, cardiac surgery patients or people who are obese. How can we improve the dosing of painkillers for these patients? Hospital pharmacist Sjoerd de Hoogd of the St. Antonius Hospital in Utrecht investigated this. He combined data from the hospital with the knowledge and expertise of the Leiden…
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‘Take medicine target saturation into account’
Not taking into account the saturation of drug targets can lead to wrong conclusions about the duration of a drug's action. This is what former PhD candidate Wilbert de Witte writes together with the Leiden professors of pharmacology Meindert Danhof, Piet van der Graaf, and Liesbeth de Lange in Nature…
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A game of Mastermind to unravel Alzheimer’s disease
In order to better understand the course of Alzheimer’s disease, Frédérique Kok believes that a strategic and structured approach is needed: the Mastermind research approach. With her LUF grant, Kok wants to generate high-quality data to build a mathematical model that can recognize the onset of the…