2,130 search results for “heart diseases” in the Public website
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Breakthrough by Leiden researchers in Pompe disease
Researchers at Leiden University have made a breakthrough in the study of the hereditary Pompe disease. Together with colleagues in York, they have developed a molecule that binds to the enzyme that is key to the progress of the disease. The findings have been published in ACS Central Science.
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Analysing diseases through interactive visual interfaces
Alzheimer’s disease and cancer are two examples of diseases that are related to malfunctioning cellular patterns. The examination of cell tissue, however, takes a lot of time and generates a lot of data. To make the analysis of data easier, Antonios Somarakis of the Data Science Research Programme (DSRP)…
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Microplastics in artery plaque linked with higher risk of heart attack, stroke and death
You can't see them with the naked eye, but they are highly likely to pose a threat to our health: microplastics. These tiny plastic particles are present everywhere in the environment, including within our bodies. On science platform The Conversation molecular biologist Meiru Wang offers valuable insights…
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A game of Mastermind to unravel Alzheimer’s disease
In order to better understand the course of Alzheimer’s disease, Frédérique Kok believes that a strategic and structured approach is needed: the Mastermind research approach. With her LUF grant, Kok wants to generate high-quality data to build a mathematical model that can recognize the onset of the…
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Making the most of the first time a medicine is administered to humans
Collecting as much information as possible about administering a new medicine to people can save a lot of money.
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Zebrafish models for disease and environmental stress
We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.
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Preventing or curing diseases with X-omics
In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…
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Single gold nanorods in live cells
Visualization of biomolecules in living cells by tagging with gold nanoparticles.
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Immunity in atherosclerosis: novel assays, biomarkers and therapeutic approaches
Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.
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Seeking new concepts to treat diseases
Scientific Director of the Leiden Academic Centre for Drug Research (LACDR) Hubertus Irth: ‘We test substances and look for new concepts for treating disease.’
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Developing new therapies to fight muscle disease
Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…
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Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands
Supervisor: Andrea Martella
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On imagination in science: ‘A good researcher is also an inventor’
As far as Daniël Pijnappels, Professor of Cellular Electrophysiology, is concerned, both researching and inventing are essential for a scientist.
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Voila/Neuromet
To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.
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Discovery and characterization of new glucosylated metabolites: pathophysiological consequences
Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.
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Willem Fibbe
Faculteit Geneeskunde
w.e.fibbe@lumc.nl | +31 71 526 2271
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Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
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Bacteria inside plant roots battle fungal disease
Two bacterial species team up inside the plant root system to rescue their host from fungal infection. This was discovered by a team of microbiologists and bioinformaticians from the Netherlands Institute of Ecology, Wageningen University, and the Institute of Biology Leiden. They also identified the…
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About the programme
PHM offers you the tools to navigate through, and give direction to, the complex and changing health care landscape by using an interdisciplinary approach. Become the broker to improve health and societal outcomes for citizens and patients.
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Ilze Bot receives prestigious grant from the Dutch Heart Foundation
Just before Christmas, three talented scientists received good news: they are receiving a personal research grant from the Dutch Heart Foundation. Ilze Bot of the Leiden Academic Centre for Drug Research is one of those scientists. She will receive an Established Investigator grant of 650,000 euros.…
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Leiden: The scene of the Zebrafish Disease Models conference 2018
In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…
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Two-pronged attack on infectious diseases
A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.
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‘A revolution is coming in treatments for neurodegenerative diseases’
Professor by Special Appointment of Clinical Neuropharmacology Geert Jan Groeneveld will deliver his inaugural lecture entitled ‘The importance of the biomarker’ on 11 March 2022. According to him, new genetic knowledge will revolutionise drug research.
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager
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Bio-inspired engineering to fight emerging viral diseases
Leiden Scientists are getting prepared to tackle future epidemics. A group of scientists led by Dr. Alireza Mashaghi has used innovative engineering approaches to make the first “Lassa Hemorrhagic Syndrome on-a-Chip”. World Health Organization has listed Lassa fever among diseases that pose the greatest…
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Elizabeth (Liesbeth) de Lange
Science
ecmdelange@lacdr.leidenuniv.nl | +31 71 527 6330
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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10 million for research into disease transmission by mosquitoes
How can the Netherlands be better prepared for infectious diseases transmitted by mosquitoes. The Dutch Research Council (NWO) has awarded almost 9 million euros for this research. Maarten Schrama from the Institute of Environmental Sciences CML coordinates the input of Leiden University within the…
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NWO grant for super fast analysis of disease progression
New funding allows IBL-researcher Herman Spaink to purchase a measurement device for more studies on human diseases such as cancer and tuberculosis using zebrafish as the model system.
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Deciphering the link between Iron and Brain Disease
Aceruloplasminemia is a very rare, genetic disease accompagnied with iron accumulation that causes movement disorder and brain damage at early age.
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Using zebrafish to target the Achilles’ heel of cancer
Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.
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Perception of multidimensional speech sounds in humans and songbirds
Do humans and zebra finches share cognitive mechanisms that are important for speech perception?
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Neurogenomics of vocal learning
How does FoxP1 affect auditory perception on a behavioural and genomic level?
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Collaborating on big data to unravel disease processes
Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.
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Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.
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Inaugural lecture: Research into accelerating rare disease research through registries
On 3 April, Professor Syed Faisal Ahmed from the Leiden University Medical Center (LUMC) will give his inaugural lecture ‘Strength in Numbers’. He will emphasise the benefit of registries to rare disease research.
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Tim Koppert
Faculteit der Sociale Wetenschappen
t.y.koppert@fsw.leidenuniv.nl | +31 71 527 2727
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Maia Casna
Faculteit Archeologie
m.casna@arch.leidenuniv.nl | +31 71 527 2727
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Marit Ruitenberg
Faculteit der Sociale Wetenschappen
m.f.l.ruitenberg@fsw.leidenuniv.nl | +31 71 527 2727
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Katja Cardol
Faculteit der Sociale Wetenschappen
c.k.cardol@fsw.leidenuniv.nl | +31 71 527 5697
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Jyothi Thrivikraman
Faculty Governance and Global Affairs
j.k.thrivikraman@luc.leidenuniv.nl | +31 70 800 9500
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Wijnhaven: reviving the heart and soul of The Hague
Looking at the photograph above, it’s hard to realise that this was once the area around the Wijnhaven.
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Shaping proteins to understand chaperone-related diseases
Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.
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Mapping of bacterial genomes to combat infectious diseases
Mapping of bacterial genomes to combat infectious diseases
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Unspinning chromatin: molecular mechanisms of chromatin remodeling
How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?
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Medicine/Leiden University Medical Center
We are very happy to welcome you to spend a semester or year studying or doing an internship with us at the Leiden University Medical Center. Here you will find information on your course timetables and registration.
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Thrips resistance in strawberry: more fruits with less pesticides
Can thrips resistance in strawberry be explained based on secondary metabolite profiles and plant morphological traits?
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Regulation of vegetative development and life history strategy in plants
How is vegetative development regulated in plants and how does this affect a plant’s life history strategy?
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Streptomyces as cell factories
We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.