734 search results for “targeted therapy” in the Public website
-
From Data to insight
Social science research helps us understand human behaviour and social structures. These are determined by various factors, which makes the research complex and increases the likelihood of drawing the wrong conclusions. The choice of research method and analysis is therefore extremely important. It…
-
United States
This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with Boston Children’s Hospital in the USA.
-
Physics and Engineering Approaches to Biomedicine and Pharmacology
Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.
-
Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
-
Vision and Mission
The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.
-
Review paper on the potential impact drug-metabolizing enzymes on brain exposure
PhD candidate Mengxu Zhang (Division of Systems Pharmacology and Pharmacy) published a comprehensive and important review on “The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure” in Drug Metabolism Reviews.
-
‘Cancer treatment should be a six-week life event’
When internist Christian Blank made his very first discovery, his field of immunotherapy was the underdog of cancer research. Now, over 20 years later, Blank has been appointed Professor By Special Appointment of Internal Medicine for his clinical research into immunotherapy and will give his inaugural…
-
Child Cancer Fund subsidises statistical research
Marta Fiocco, professor in the Mathematical Institute, has received a grant for analysing data on chemotherapy in children suffering from leukaemia. The work involves developing and applying new statistical methods that will help determining the optimal dose of chemotherapy.
-
Thorbald van Hall delivers inaugural lecture on training the immune system to counterattack escaping tumours
On 10 September 2021, Professor Thorbald van Hall from the Department of Medical Oncology in the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Tumour-immune interactions: control, escape and counterattack’. Van Hall used the opportunity to describe how - in a similar way to…
-
A multi-million grant to keep the biological clock healthy
Dutch researchers are joining forces to conduct research together with a series of societal partners to keep the biological clock healthy in our modern 24-hour society. The BioClock consortium will receive a research grant of no less than 9.7 million euros for this. It is one of the projects that receive…
-
Fighting gliobastoma brain tumours with two grants
Few researchers see potential in research on glioblastoma, an incurable brain tumour. Alexander Kros brought together colleagues who are up to the challenge. European research funder ERC recently made 10.6 million euros available, a year earlier NWO provided 3 million euros. ‘In six years, we certainly…
-
Oh no, a mistake! Investigating the constant performance monitoring in our heads
Psychologist Myrthe Jansen conducted research into the performance monitoring that constantly takes place in our heads. People with obsessive-compulsive symptoms are more afraid to make a mistake that harms others, than when they make a mistake that only harms themselves. Jansen received her PhD on…
-
Serious game helpt mensen met Niet Aangeboren Hersenletsel (NAH) opnieuw te navigeren
Om de weg te vinden letten sommige mensen op de omgeving, anderen onthouden waar ze links of rechts af moeten slaan. Mensen met Niet Aangeboren Hersenletsel (NAH) rapporteren navigatieproblemen. Om opnieuw te leren navigeren heeft neurowetenschapper Milan van der Kuil als revalidatietherapie een serious…
-
On this public day on psychedelics, researchers transcend the media hype
Never before has so much research been carried out on the therapeutic effect of psychedelic drugs. Researchers at the LIBC Public Day are happy about the effect the drugs can have on depression, anxiety and PTSS, but at the same time they have some doubts. ‘The hype is bound to crash before long.’
-
ZonMw grant for major research into causes of dementia
The Mechanisms Of DEMentia (MODEM) research project has received a €5,9m grant from ZonMw. Within this collaboration, several parties, including the Leiden University Medical Centre (LUMC), will conduct research into the causes of dementia.
-
On imagination in science: ‘A good researcher is also an inventor’
As far as Daniël Pijnappels, Professor of Cellular Electrophysiology, is concerned, both researching and inventing are essential for a scientist.
-
A unique defence: Bacteria lose cell wall in the presence of virus
Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…
-
Men are not better than women at navigating, although they think they are
Last year, more than 8,000 respondents in the Netherlands took part in a public survey on their navigation behaviour. Headed by neuroscientist Ineke van der Ham from Leiden University, as part of the Weekend of Science, the survey studied how people navigate.
-
‘Tolerance and respect will advance medical science’
Fijs van Leeuwen, Professor of Radiology, Molecular Imaging and Image-Guided Therapy, advocates an open and respectful academic culture that always puts the patient first. He delivered his inaugural lecture on 13 November.
-
Translating science into treatments of rare metabolic disorders
Leiden biotech startup Azafaros has successfully completed a funding round, raising 25 million euros of investments for developing treatments of rare metabolic disorders. The company holds exclusive license to a library of novel patented compounds discovered by experts from Leiden University.
-
Drugs with fewer side effects through a collaboration between LACDR and PTS
LACDR, the Leiden Institute for Drug Research, developed better tolerated excipients to prevent adverse effects related to the surface of nanosized drugs such as vaccines. LADCR professor of Biopharmacy Matthias Barz and Polypeptide Therapeutic Solutions (PTS) are collaborating to develop processes…
-
Government pledges millions for economic growth
The government is investing 646 million euros and has set aside a further 3.5 billion to drive economic growth in the Netherlands. Much of the National Growth Fund will be used for scientific innovations. Leiden University is involved in three of the projects.
-
Drawing and predicting lines: how artificial intelligence is helping doctors
Artificial intelligence can help doctors analyse images such as MRI scans. In future it may even be able to predict how a tumour will grow. And that is badly needed to relieve the pressure on healthcare workers.
-
Promising new technique to treat cancer receives NWO grant
Biological chemist Nathaniel Martin and his team received an NWO grant to examine how blocking a specific enzyme in our body, NNMT, could be helpful in the treatment of some cancers. Trials with mice have been promising, and together with the Netherlands Cancer Institute, Martin wants to take the next…
-
These are the seven Veni winners of the Faculty of Science
The Faculty of Science has received no less than seven Veni grants this year. Camila Correa, Max van Duijn, Stéphanie van der Pas, Sergii Pud, Mónica Varela Álvarez, Joseph Callingham, and Melissa McClure will receive a maximum of 250,000 euros to further develop their own research ideas over a three-year…
-
Quantum particles and bacteria without cell walls: KLEIN grant for Beenakker and Claessen
Are Weyl particles the ideal conductors? Do cells without a cell wall play a role in chronic Tuberculosis infections? Carlo Beenakker and Dennis Claessen want to answer these questions. They both received a KLEIN grant from the NWO. With these grants, NWO wants to stimulate innovative, fundamental r…
-
King of Sweden visits Leiden University
Collaborating in drug discovery and health research was the goal of a visit to the Leiden Bio Science Park on 14 May by a Swedish delegation including His Majesty King Carl XVI Gustav of Sweden. The delegation visited Leiden University’s Faculty of Science.
-
Ilze Bot appointed professor of Cardiovascular Pharmacology
Dr Ilze Bot (LACDR) has been appointed professor of Cardiovascular Pharmacology with effect from 1 March. A recognition of her work as a scientist. 'This allows me to continue and expand my line of research within the LACDR and Leiden University.'
-
Andrea Evers installed as a new KNAW member
Health psychologist Andrea Evers is one of the 19 new members, selected by the Royal Netherlands Academy of Arts and Sciences (KNAW), who have been inaugurated on 16 September 2019. The Academy has now about 550 members.
-
'AI for Healthcare Robotics'. New book by Eduard Fosch-Villaronga and Hadassah Drukarch
Eduard Fosch-Villaronga and Hadassah Drukarch from eLaw - Center for Law and Digital Technologies, recently published the book ‘AI for Healthcare Robotics’, published by CRC Press from Taylor and Francis Group in their AI for Everything Series.
-
Two KWF grants for LUMC on AI for precision oncology
This week, the Dutch Cancer Foundation (KWF) has awarded two research grants to LUMC researchers that include the development of advanced AI technology to improve and personalize oncological treatment.
-
Student teams present their start-ups at final summit Innovation, Co-Creation and Global Impact
From a service stimulating intercultural contacts at work, to pet therapy against stress. An energizing table lamp reducing winter fatigue, and a website informing internet users on their rights. Thursday 24th of January, the student teams of FGGA minor Innovation, Co-Creation and Global Impact presented…
-
Publication PhD student Eva Kritikou accepted in Scientific Reports:
A recent publication by Biopharmaceutics PhD-candidate Eva Kritikou has been accepted by the renowned scientific journal Scientific Reports.
-
The Department of Child Law welcomed delegation from Tunisia
On Thursday 17 November 2016 a delegation from the Ministry of Justice, the Ministry of Social affairs and UNICEF Tunisia paid a visit to Leiden Law School, organised by the International Juvenile Justice Observatory.
-
Article award for Andreas Burger
At the annual meeting of the postgraduate school for Experimental Psychopathology (April 6th), Andreas Burger was awarded the article prize for best academic paper of 2017.
-
Was there forced labour at Dutch youth institution De Goede Herder?
The civil lawsuit against the Congregation of 'Onze Lieve Vrouw van Liefde van de Goede Herder' starts this week. A total of 19 women, aged from 62 to 91, together with the women’s rights foundation Clara Wichmann wants recognition through the courts that there was a situation of forced labour at youth…
-
ZonMw Medical Inspirator Prize for research ‘Lyme paralyses lives’
Together with patient representatives, clinician-researchers from Radboucumc (Internal Medicine) Amsterdam UMC and researchers from Leiden University (Andrea Evers and Henriët van Middendorp) have received the Medical Inspirator Prize 2019 of The Netherlands Organisation for Health Research and Development…
-
LED3 Lecture: Chemical Probes for imaging and analysis of hydrolase function in Cancer, Infectious Diseases and the microbiome
Lecture
-
LED3 Lecture: Prof. Carolyn Bertozzi
Lecture
-
Renewable Energy
The transition to new and renewable energy sources should be completed by 2050. Researchers in various disciplines at Leiden University are conducting unique research that will help us make this transition and reduce CO2 emissions.
-
The developing brain and behaviour
The more opportunities a child has to learn and develop, the stronger his or her future position in society. Leiden University investigates how the brain picks up information, and how learning processes can be influenced positively.
-
Governance and society
Governance is a complex puzzle of organisations, people and divergent interests. Academic research in this field furthers our knowledge of the role of public administrators, of different organisational structures, of the people who work at such organisations and of how these organisations implement…
-
A fitting punishment
A punishment that fits the crime is the cornerstone of the rechtsstaat or constitutional state. But opinions differ greatly on what constitutes a just and effective punishment. Research by Leiden University provides politicians, legislators, law enforcers and the public with new information and insights…
-
Probing complex problems
Issues such as climate change, the depletion of natural resources or social inequality are too complex to be addressed from a single scientific discipline or by a single country. Leiden University has the expertise to bring the resolution of these enormous problems a small step closer.
-
Indigenous Peoples preserved
Indigenous Peoples possess rich worldviews and unique knowledge that form part of our global heritage. Oppressing these peoples and violating their natural environment is leading to the destruction of this knowledge. Leiden researchers aim to counter this through collaborating with Indigenous Peoples…
-
We all BENEFIT: The Ecosystem for Healthy Living
The modification of risk factors and related health behaviors lies at the very core of adequate cardiovascular risk management, yet evidence shows that the majority of people with cardiovascular disease (CVD) fail to achieve a healthy lifestyle in the long term. The main objective of this project is…
-
The quantum computer
The worldwide race to the quantum computer is in full swing. This computer can take on computing tasks that we can only dream of today, such as finding proteins that can be used as medicines in seconds flat. Leiden physicists have discovered how the Majorana particle can be used as a building block…
-
Fundamental and translational medical biochemistry
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
-
Pharma-NL application submitted to National Growth Fund
The Ministry of Health, Welfare and Sport (VWS) submitted Pharma-NL to the R&D program of the National Growth Fund, a 20 billion euro program of the Dutch government that intends to create long-term economic growth in The Netherlands.
-
Leiden collaboration supports development of vaccine against coronavirus
The Department of Medical Microbiology of Leiden University Medical Centre (LUMC) will investigate the efficacy of a new experimental vaccine from the pharmaceutical company Jansen against the coronavirus. The research is being conducted in collaboration with the The Janssen Pharmaceutical Companies…