Research in the BioTherapeutics research programme is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

A very large part of intravenously administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by macrophages (Kupffer cells). To achieve effective cell-specific targeting of drugs and non-viral gene delivery vectors, improved mechanistic…

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Research from the Living Lab is important for society. For example, scientists from the Living Lab discovered that the pesticide thiacloprid is up to 2,500 times more harmful to insects than was thought on the basis of regular lab research. Partly because of this discovery, the European Commission decided…

Patients share valuable advice and experiences with their peers in online patient discussion groups.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

Promotor: Prof.dr. G.P. van Wezel

While bioinformatics methods deal with the analysis of sequence information (be it proteins or DNA), the field of cheminformatics is concerned with the analysis of small-molecule datasets.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Grants awarded to molecular physiology research

Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…

How can we implement the technique of pharmacological resting-state fMRI to improve the diagnosis of dementia?

Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.

The LED3 hub, consisting of researchers from the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden (IBL) and the Leiden Academic Centre for Drug Research (LACDR), is very excited to organize the “LED3 Lectures”. This lecture series brings world-leading researchers in the field of…

Many students receive their first job offer during or right after their Business Studies internship. After graduating you can also aim for a career in Bio-Pharmaceutical research.

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.

Debate

The world is full of wars, and no war is without its dead. What happens to the bodies of fatal casualties of armed conflict? The winner of the faculty Jongbloed Thesis Prize 2015 is Welmoet Wels (Public International Law). Her thesis Dead body management in armed conflict: paradoxes in trying to do…

Do you recall all those drugs that were hastily proposed as potential treatments for COVID-19? In the event of a future pandemic, the goal is to offer an effective treatment more quickly and efficiently. To achieve this, a team led by Coen van Hasselt is developing a platform that can speed up the process…

Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…

Everything you need to know about the minor Cultural Memory of War and Conflict.

Debate, Roundtable discussion

Lecture

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

The Heritage Quest project begins on Monday 6 April. Heritage Quest is the first large-scale citizen science archaeology project in the Netherlands: anyone can help find archaeological remains at Utrechtse Heuvelrug, a heavily forested region in the Netherlands. Citizens can thus get involved in scientific…

The Russian invasion of Ukraine has also had dramatic consequences for Ukrainian students at Leiden University. Besides their intense concern about the fate of family and friends, they also face major financial problems. This also applies to Russian students who can no longer access their bank accounts.…

PhD defence

Within just a few years, the Chinese government's policy towards the Uyghurs deteriorated sharply. From control and marginalisation, it shifted to violation of human rights. PhD candidate Elke Spiessens was right in the middle of it with her research. 'The fabric of the community is being completely…

Frank van Vree, Emeritus Professor of War, Conflict and Memory Studies at the University of Amsterdam (UVA), is the new Cleveringa Professor at Leiden University this year.

Lecture

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

The minors offered by the Faculty of Governance and Global Affairs in The Hague are closely linked to the defining image of The Hague as a city of international justice, peace and security as well as the centre of Dutch public administration and international governance.

The most densely populated country in Africa, Nigeria, is fighting a war on two fronts. Not only is Nigeria being confronted with violence on a national level by terror group Boko Haram, on a regional level there are conflicts between shepherds and farmers.

Have you ever wondered what law has accomplished in different countries and jurisdictions? If it even has accomplished anything at all, or that it are all promises of a better world? And have you ever thought about the role of law in the war on terror, in climate change, in emancipation and protection…

Promotores: F.H. van Lunteren, F.P. Israel

This project asks how individuals and society dealt with personal memories of the Dutch Revolt: narrating, writing, explaining, understanding, and coming to terms with what happened by first and following generations.

Embryonic stem cells have the remarkable ability to develop into any type of cell. On their way to become for example a liver or a heart cell, they must repeatedly decide between alternative developmental paths. How they make these decisions is largely unknown. An international team of biophysicists…

A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.

Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’

He has had to accept early retirement due to his military profession, or ‘FLO’ (Functioneel Leeftijdsontslag) as it is more commonly referred to within the Dutch Ministry of Defence, but the words ‘retirement’ or ‘winding down’ do not appear to be part of Frans Osinga's vocabulary. His appointment at…

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…

The two-years MSc programme spans the entire spectrum of Analytical BioSciences, Biopharmaceutics, Drug Delivery Technology, Medicinal Chemistry, Pharmacology and Toxicology.

Fascinated by science since high school, Alireza Mashaghi Tabari is driven to explore new ways of thinking in medicine. With a strong academic network, he educates students and gives public lectures. For his research at LACDR, he won the C.J. Kok Public Award 2018, making him the Faculty of Science's…

It is a stormy Sunday afternoon, with gusts of a whopping 110 kilometres per hour. Chemist Teun Sweere defies the enormous headwind on his city bike and wins the NK Headwind cycling after 22,5 minutes. A new highlight follows six months later: his PhD defence (14 June).

The project focusses on how US views of the Chinese diaspora in Southeast Asia influenced its strategic interpretations of the region. Being eleven million strong, dispersed across the region and sharing ethnic ties with Communist China, interpretations of the diaspora intersected with key Cold War…

An experimental comparison of the impact of liberal norms on a population residing and socialised within a democracy (the Netherlands) with a population in an autocracy (China) and their respective supports for war with another state shows that the level of liberal norms in the democratic experimental…