244 search results for “organ transplantation” in the Public website
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Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients
Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
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The dynamic organization of prokaryotic genomes: DNA bridging and wrapping proteins across the tree of life
Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.
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Understanding the physical properties that affect the lipid organization in the skin barrier
It is the aim of this project to better understand how the physical properties of lipids influences the structure and overall barrier function of the skin.
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behavior of skin lipid mixtures: the effect of cholesterol on lipid organization
The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).
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Beyond Empires: Global, Self-Organizing, Cross-Imperial Networks, 1500-1800
Beyond Empires explores the complexity of empire building from the point of view of self-organized networks, rather than from the point of view of the central state.
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Scalable organic solvent free supercritical fluid spray drying process for producing dry protein formulations
In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.
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Sarita Koendjbiharie
Faculty of Humanities
s.r.koendjbiharie@hum.leidenuniv.nl | +31 70 800 9535
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debate: citizens’ perceptions of meritocracy in public and private organizations
Public management scholars have long debated public and private sector differences. However, the generalizability of empirical results has been limited due to the shortage of cross-national studies.
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The monastery rules : buddhist monastic organization in pre-modern Tibet
This study discusses the position of the monasteries in pre-1950s Tibetan societies and how that position was informed by Buddhist monastic ideology.
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
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Student projects
Are you looking for a research project?
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The formation of complex organic molecules in dense clouds-Sweet results from laboratory
Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.
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Silva Nova – Restoring soil biology and soil functions to gain multiple benefits in new forests
We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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MICA-mediated immunity: a new opportunity for improving corneal graft survival
Corneal transplantation is one of the most common human organ transplantations worldwide. Although the 1-year survival rate is as high as 90%, more than half of transplantation patients suffer various types of corneal rejection, such as epithelial rejection, chronic stromal rejection, and endothelial…
- The Challenge of Enforcing Rule of Law in International Organizations: Winning the Public and Resisting Populist Attacks [CHARLIO]
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The man who sewed a new man together
Organ transplantation is often subject to ethical, economic and political discussions. In the Honours Class Organ Transplantation, students take part in these discussions to get a better understanding of the many different views on transplantation.
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Coarticulation and polyphonic expression in the performance of piano and organ music
Performances of solo keyboard repertoire can sound more or less polyphonic depending on the performer’s use of divergence in expression.
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Repair a bad kidney or make a new one to order
Searching for ways to delay the need for a transplant and trying to build kidneys to order.
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Dirk-Jan Kok
Science
d.d.kok@cml.leidenuniv.nl | +31 71 527 2727
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Ton Koopman
Faculty of Humanities
a.g.m.koopman@hum.leidenuniv.nl | +31 71 527 1480
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Michiel Veldhuis
Science
m.p.veldhuis@cml.leidenuniv.nl | +31 71 527 1494
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Targeting macrophages in renal transplantation
PhD defence
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Can Chinese legislation on informational privacy benefit from European experience?
What is a good data protection law? How does a good data protection law evolve? Is European data protection law a good one? And whether the European data protection applicable to China?
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This is life: some thoughts on self-organized structure formation in active liquids and biological systems
It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.
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Novel approaches to develop filamentous micro-organisms for enzyme production (FILAZYME)
Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?
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Mosaic-Craftsmen and Workshop-organization in the Provinces of Arabia and Palestina during Late-Antiquity
This research focuses on figurative Byzantine mosaic-floors that have been excavated in the geographical area of the ancient provinces of Palestina and Arabia (current Israel, PA and Jordan) dating to the Late 5th, 6th and early 7th centuries C.E.
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Inloopconcert Universiteitsorgel
Arts and culture
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Patient-relevant outcomes after kidney transplantation
PhD defence
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Antonius Johannes Rabelink
Faculteit Geneeskunde
a.j.rabelink@lumc.nl | +31 71 526 2148
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"Getting Organized"
In January 2014, the research project The Promise of Organization hosted a fruitful three-day conference:
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Hellenistische Rechtsfiguren in het Romeins Recht
In what way did Hellenistic legal institutions concerning secured credit influence Roman law?
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Christian missions and societies in the Middle East: organizations, identities, heritagization (XIXth-XXIth centuries)
The project re-examines the role of the Catholic, Protestant and Orthodox missionaries in the cultural and social developments of the Middle East and their interactions with the indigenous communities, from the nineteenth century until today. It seeks to discover and retrace such ‘entangled histories’…
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European Council and the European Commission in the policy domain of organized crime
The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…
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Stem cells as cure
Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.
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Ewa Snaar-Jagalska
Science
b.e.snaar-jagalska@biology.leidenuniv.nl | +31 71 527 4980
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Flentrop organ in Academy Building turns 25: ‘It’s a whole orchestra’
The organ in the Academy Building is 25 years old. University organist Jan Verschuren and tuner Bert Crama talk about the long history of university organs, improvising with short cortèges and their love for this organ.
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Transfusion Medicine and Cellular and Tissue Therapies (MSc)
This joint Master with the Autonomous University of Barcelona will the equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. The programme includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy, and…
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Macrophages and atherosclerotic lesions
Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…
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Old English Medievalism: Reception and Recreation in the 20th and 21st Centuries
An exploration across thirteen essays by critics, translators and creative writers on the modern-day afterlives of Old English, delving into how it has been transplanted and recreated in the twentieth and twenty-first centuries.
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Free large scale online education: MOOCs
Everyone wherever they are in the world can follow free online academic courses offered by Leiden University.
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pharmacometrics to optimize immunosuppressive therapy in kidney transplantation
PhD defence
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pharmacokinetics and dynamics in pediatric allogeneic stem cell transplantation
PhD defence
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Improving survival prediction models for liver transplantation candidates
PhD defence
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'The Love for International Organizations'
A conference organized by Niels Blokker, professor of International Institutional Law and Ramses Wessel (RUG) to celebrate the 20th anniversary of the International Organizations Law Review.
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'Q-wires': Synthesis, electrochemical properties and their application in electro-enzymology
An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.
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A spam box full of opportunities
The certificate award ceremony of the Honours College took place in the Hooglandse Church in Leiden on Tuesday 21 November. During the ceremony, two students shared their experiences with honours education while Vice-Rector Hester Bijl addressed the students.
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Cardiovascular and Metabolic Therapeutics
This research group, headed by Miranda van Eck, focusses on understanding the molecular mechanisms underlying cardiovascular and metabolic diseases. Cardiovascular disease constitutes a major health issue worldwide. Although significant knowledge has been obtained on the development of atherosclerotic…
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Remus Dame
Science
rtdame@chem.leidenuniv.nl | +31 71 527 5605