471 search results for “modelling 20” in the Public website
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Huub de Groot
Science
groot_h@chem.leidenuniv.nl | +31 71 527 4539
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‘Our students are role models for young children in The Hague’
What better way is there for an alderman to find out where best to put his efforts than to pay a working visit to the university? Hilbert Bredemeijer, Alderman in The Hague for Education, Sport and the Outdoor Space, paid a visit to Campus The Hague on Wednesday 6 October 2021.
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Improving vegetation representation in Multi-sensor Earth Observation Products through phenology and trait-based priors
What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?
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Calculated Moves: Generating Air Combat Behaviour
By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Blowup in the complex Ginzburg-Landau equation
Promotor: A. Doelman, Co-promotor: V. Rottschäfer
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G-zips and Ekedahl-Oort strata for Hodge type Shimura varieties
Promotores: S.J. Edixhoven, F. Andreatta
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Czech Ambassador to The Netherlands visits Leiden to mark the 20 year anniversary of European Enlargement
On Tuesday, April 16, 2024, students, instructors, staff and other guests gathered at the Faculty Club for an exciting event: a discussion entitled “The First 20 Years: Reconsidering European Union Enlargement into Central and Eastern Europe.” His Excellency Mr. René Miko, Ambassador of the Czech Republic…
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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15th Leiden-Sarin International Air Law Moot Court Competition (18-20 April 2024)
Leiden’s International Institute of Air and Space Law (IIASL) was delighted to co-organise the 15th edition of the Leiden-Sarin International Air Law Moot Court Competition alongside this year’s host, the National Autonomous University of Mexico (UNAM) in Mexico City. The event brought together around…
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Publication | Introduction: WPS 20 Years On: Where Are the Women Now?
To commemorate the twentieth anniversary of Resolution 1325, this introduction discusses the state of the field in the women peace and security (WPS) agenda and outlines the challenges to implementation. It begins by ntroducing the current gaps we see in WPS practice, many of which are driven by…
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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On transport properties of Majorana fermions in superconductors: free & interacting
Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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Ages: Collections, Mediators and the Practice of Compiling (KNIR, 17-20 October)
From October 17 to October 20, the international conference "Patristic Sermons in the Middle Ages: Collections, Mediators and the Practice of Compiling" will take place at the Dutch Royal Institute in Rome. Research Master students can obtain 2 ECTS by participating in this conference an an additional…
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Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
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When data compression and statistics disagree: two frequentist challenges for the minimum description length principle
Promotor: P.D. Grünwald
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Structural Health Monitoring Meets Data Mining
Promotor: Prof.dr. J.N. Kok, Co-promotor: Dr. A.J. Knobbe
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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Uniform infinite and Gibbs causal triangulations
Promotor: Richard D. Gill
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Monitoring Alzheimer's disease in transgenic mice with ultra high field magnetic resonance imaging
Promotor: H.J.M. de Groot, Co-Promotor: A. Alia
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Invariant manifolds and applications for functional differential equations of mixed type
Promotor: S.M. Verduyn Lunel
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Dual Complexes of Semistable Varieties
This thesis is comprised of three chapters covering the theme of studying semistable varieties by looking at their dual combinatorial objects.
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Herman Spaink
Science
h.p.spaink@biology.leidenuniv.nl | +31 71 527 5055
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Yingjie Fan
Science
y.fan@liacs.leidenuniv.nl | +31 71 527 4799
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Tomer Fishman
Science
t.fishman@cml.leidenuniv.nl | +31 71 527 2727
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Garnet Akeyr
Science
g.j.akeyr@math.leidenuniv.nl | +31 71 527 4845
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Bas ter Braak
Science
s.j.ter.braak@lacdr.leidenuniv.nl | +31 71 527 2727
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Marije Niemeijer
Science
m.c.niemeijer@lacdr.leidenuniv.nl | +31 71 527 6105
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‘The Afghan state has collapsed, but the democratic gains of the past 20 years are not lost’
The international conference ‘Lessons from Afghanistan’ touched on many serious issues and raised several reasons for concern. But it also ended on a positive note. While politicians on both the domestic and the international levels have failed to prevent the collapse of the Afghan state, and we are…
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Laurens Smit awarded for best PhD student in Operations Research/Management Science
The New Jersey Chapter of the international Institute for Operations Research and the Management Sciences
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Laboratories for Digital Archaeology
The Digital Archaeology research group manages two computer laboratories with different purposes: the teaching lab (F1.01) and the research lab (A1.13a).
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Modeling progress: event types, causal models, and the imperfective paradox
Lecture, Com(parative) Syn(tax) Series
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
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New technique to study vascular growth
Sonja Boas developed new techniques to study vascular growth computationally. The results of her research provide a better understanding into mechanisms behind vascular growth, which is relevant to the development of medical therapies. She defends her thesis 'Computational modeling of angiogenesis'…
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Applications of Large Language Models to the Humanities Workshop
Workshop
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Model painting with diverse techniques
Arts and leisure, Arts and leisure
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Peter Bouwman
Science
r.j.p.bouwman@lacdr.leidenuniv.nl | +31 71 527 6105
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SMALL Savannah : an information system for the integrated analysis of land use change in the Far North of Cameroon
Promotores: W.T. de Groot, M. Tchuenté, Co-promotor: J.P. Cheylan
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Gibbs-non-Gibbs transitions and vector-valued integration
Promotor: W. T. F. den Hollander, F. H. J. Redig
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Semi-partitioned Scheduling and Task Migration in Dataflow Networks
Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov
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Interactive scalable condensation of reverse engineered UML class diagrams for software comprehension
Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron, Co-Promotor: P. van der Putten
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Atomic Insights into Hydrodesulfurization
Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.