613 search results for “3d modelling” in the Public website
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Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
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Actors at work
Promotor: F.S. de Boer Co-promotor: P. T. de Gouw
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Research
Research lines within the Pharmacy group:
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Multi-Objective Bayesian Global Optimization for Continuous Problems and Applications
A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.
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Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
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Multi-dimensional feature and data mining
In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Anyonic, cosmic, and chaotic: three faces of Majorana fermions
In my thesis I study Majorana fermions from three different perspectives. The first one corresponds to non-interacting Majorana fermions that, however, pose non-trivial topological properties. The second one corresponds to strongly interacting Majoranas and the third to relic neutrinos. No one knows…
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Baoxiao Liu
Science
b.liu@cml.leidenuniv.nl | +31 71 527 5615
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Huub de Groot
Science
groot_h@chem.leidenuniv.nl | +31 71 527 4539
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Maarten van 't Zelfde
Science
zelfde@cml.leidenuniv.nl | +31 71 527 5631
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Anjali Pandit
Science
a.pandit@chem.leidenuniv.nl | +31 71 527 4198
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Niki van Stein
Science
n.van.stein@liacs.leidenuniv.nl | +31 71 527 2727
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Peter van Bodegom
Science
p.m.van.bodegom@cml.leidenuniv.nl | +31 71 527 7486
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Matthijs van Leeuwen
Science
m.van.leeuwen@liacs.leidenuniv.nl | +31 71 527 7048
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Md Faysal Tareq
Science
m.f.tareq@cml.leidenuniv.nl | +31 71 527 2727
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Nuno De Mesquita César de Sá
Science
n.q.de.mesquita.cesar.de.sa@cml.leidenuniv.nl | +31 71 527 2727
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‘Our students are role models for young children in The Hague’
What better way is there for an alderman to find out where best to put his efforts than to pay a working visit to the university? Hilbert Bredemeijer, Alderman in The Hague for Education, Sport and the Outdoor Space, paid a visit to Campus The Hague on Wednesday 6 October 2021.
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LIC Lecture: 3D Domain Swapping of Proteins: Basics and Recent Developments
Lecture
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Improving vegetation representation in Multi-sensor Earth Observation Products through phenology and trait-based priors
What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?
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Calculated Moves: Generating Air Combat Behaviour
By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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New IBL-professor in "Computational Biology": Vera van Noort
Vera van Noort has been appointed Professor in the field of Computational Biology within the Faculty of Science at the Institute of Biology from the 1st of February 2017. Van Noort’s expertise is in bioinformatics and her research focuses on the computational analysis of large-scale biological data…
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A snapshot from Saqqara: 45 years of excavations
In the past, the Dutch community living in Cairo made an annual visit to the then Leiden-only mission to Saqqara. They would come out and have a nice picnic together with the excavation team and visit the monumental New Kingdom tombs. The current Leiden-Turin expedition would very much like to revive…
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Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
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Blowup in the complex Ginzburg-Landau equation
Promotor: A. Doelman, Co-promotor: V. Rottschäfer
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G-zips and Ekedahl-Oort strata for Hodge type Shimura varieties
Promotores: S.J. Edixhoven, F. Andreatta
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Bioprinting human tissues for drug testing
Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…
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Prediction of brain target site concentrations on the basis of CSF PK: impact of mechanisms of blood-to-brain transport and within brain distribution
Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Scanning for Syria
Dutch archaeologists are making three-dimensional virtual reconstructions of archaeological objects lost in the Syrian civil war.
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3D learning in anatomical and surgical education in relation to visual- spatial abilities
PhD defence
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NL-BioImaging AM
NL-BioImaging AM is a distributed research infrastructure aimed at promoting progress in the most cutting edge microscopy technologies and providing open access to these technologies to a broad community of academic and industrial users. All Netherlands bio(medical) microscopy centers participate.
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Cells with stress: predicting drug-induced liver and kidney damage
How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.
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Data Visualization Challenge
Wouter Eekhout, our data magician, came in 3d place in the #LinksSDGs - Natural language processing and data visualization challenge.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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RNA splicing in breast cancer progression
In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.
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Human Osteology and Funeral Archaeology
The Laboratory for Human Osteoarchaeology specialises in the macroscopic and microscopic analysis of human remains. We use cutting edge scientific approaches to address archaeological, historical, and anthropological research questions. In addition to paleopathological, histological, and 3D scanning…
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Role of integrin adhesions in cellular mechanotransduction
Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen
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Novel detectors and algorithms for electron nano-crystallography
Promotor: Prof.dr. J.P. Abrahams, Prof.dr. M. van Heel
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Fluorescence Correlation Spectroscopy on Electron Transfer Reaction: Probing Inter- and Intramolecular Redox Processes
Promotores: G.W. Canters, T.J. Aartsma
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Real-time tomographic reconstruction
With tomography it is possible to reconstruct the interior of an object without destroying.
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Beyond the caves
The central question of this thesis is: What drives late Middle Paleolithic stone artifact variability? In its attempt to answer this question, this thesis is a contribution to understanding variability within and between late Middle Paleolithic assemblages of the European Plain.
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Spectral imaging and tomographic reconstruction methods for industrial applications
Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.
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Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
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Molecules during stellar formation and death
Promotor: Prof.dr. E. F. van Dishoeck, Co-promotor: A. N. Heays
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Computer Systems, Imagery & media
The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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On transport properties of Majorana fermions in superconductors: free & interacting
Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.