2,266 search results for “drug discovery” in the Public website
-
How Leiden's drug pioneers have switched to Covid research
From studying molecules in the blood of corona patients to developing a new concept for vaccines. The Leiden Academic Centre for Drug Research (LACDR) has transformed many ongoing projects into Covid research projects. Hubertus Irth, scientific director of LACDR, talks about the role of his institute…
-
Inaugural Lecture Professor Herman van Vlijmen
Prof.Dr. Herman van Vlijmen was appointed as Professor of Computational Drug Discovery at the Division of Medicinal Chemistry in Leiden on April 15th, 2008. He will give his Inaugural Lecture on May 18th, 2009.
-
Interdisciplinary research and teaching at Leiden University
Many of the challenges of our time are too complex to be resolved within the confines of a single discipline. Leiden University is a broad-based university where an incredible number of research fields converge. That makes us the ideal breeding ground for, and practitioners of, interdisciplinary research…
-
Three discoveries for cleaner and cheaper fuel
How can rare and expensive materials be used more efficiently to produce cleaner and cheaper fuel? Under the guidance of Marc Koper, Professor of Catalysis and Surface Chemistry, international teams of scientists have published 3 articles in Nature Communications.
-
Monitoring Cytoskeletal Conductance Variation for Sensing Cancer Drug Resistance
Actin and microtubules form cellular cytoskeletal network, which mediates cell shape, motility and proliferation and are key targets for cancer therapy. Changes in cytoskeletal organization correlate with proliferative capacity and invasiveness of cancer cells. These changes expectedly lead to altered…
-
Indira Nederpelt wins Young Investigator Award
Indira Nederpelt was elected as the winner of the Young Investigator Award for best oral presentation titled ‘’Kinetic characterization of clinically used GnRH peptide agonists’’.
-
Leiden discovery leads to new ageing cream and chicken feed
What do a novel anti-ageing ingredient for cosmetics and a new type of chicken feed have in common? They were both produced using a new solvent developed by Leiden biologists in 2011. The medium is neither solid nor liquid, and the industry is now starting to see it’s many possibilities.
-
Leiden discovery evaluated by world-leading breeding companies
Various companies in the plant biotech industry will test a recent Leiden discovery in their crops. The ‘Pol Theta’ technology is developed in Leiden and makes it possible to reduce undesired side effects during genome engineering of plants.
-
Research
An overview of the research at the Cancer Dug Target Discovery group.
-
Presentations eLaw at 'Brave New World' and 'Night of Discoveries'
eLaw - Center for Law and Digital Technologies, is well represented at a number of activities in Leiden this week concerning Technology and Society!
-
Lipid signaling in brain diseases
Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].
-
Partners
Our research programme collaborates with all kinds of partners to achieve our goal: bringing scientific discoveries to the clinic as soon as possible.
-
How drugs work better when encapsulated in nanoparticles
Chemist Tobias Bauer discovered ways to improve drugs by encapsulating them. Packages with iron nanoparticles, for example, can stimulate immune cells. Bauer will receive his PhD on 9 June.
-
Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
-
Night of Discoveries: 3D-printed paintings and the effects of psychedelics
Come to the Night of Discoveries art and science festival on 16 September. Various researchers from the university are speaking at the festival.
-
Admission requirements
To be eligible for Drug Discovery and Safety at Leiden University, you must meet the following admission requirements.
-
New discoveries by the Leiden-Turin excavations in Saqqara
Archaeologists from the National Museum of Antiquities (Leiden), the Museo Egizio (Turin, Italy) and Leiden University have found the grave of Panehsy, the 'steward of the temple of (the god) Amun', in Saqqara.
-
Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
-
Academic Pharma submits application to National Growth Fund
Knowledge institutions in the Netherlands are to work together with the pharma and biotech industries to accelerate drug discovery and development. To bridge the ‘lab-to-life’ gap, Leiden University and the LUMC have, as coordinators of Academic Pharma, submitted an application to the National Growth…
-
Can we live longer? Leiden physicist makes discovery in protective layer in genes
With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery…
-
The body's own marijuana as inspiration for drug research
Endocannabinoids - the body's own marijuana - are promising departure points for drug research. Professor of Molecular Physiology Mario van der Stelt examines whether inhibiting their production can be a way to fight inflammatory brain disease and to combat obesity. Inaugural lecture 19 October.
-
Innovation centre for drug development on Bio Science Park
International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.
-
Awards and Grants 2018
An overview of awards and prizes granted to our staff and students in 2018, as well as special appointments and royal distinctions.
-
LACDR EMA Lunchtalk
On Friday the 29th of October, LACDR presented highlights of its research and teaching program during an online Lunchtime Talk session at the European Medicines Agency (EMA).
-
Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
-
The archaeological discovery at the Paardenmarkt in Alkmaar
In the summer of 2010, a special archaeological find resurfaced when plans to redevelop the Paardenmarkt, a parking lot in the historic city center of Alkmaar, began.
-
Development of kinase inhibitors and activity-based probes
Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt
-
New professor of Biotherapeutics Delivery at LACDR
Matthias Barz has been appointed full Professor of Biotherapeutics Delivery at the Leiden Academic Centre for Drug Research (LACDR).
-
Roxanne Kieltyka
Science
r.e.kieltyka@chem.leidenuniv.nl | +31 71 527 4441
-
Eline Dekeyster
Faculteit der Sociale Wetenschappen
e.a.g.dekeyster@fsw.leidenuniv.nl | +31 71 527 2727
-
First discovery of high-energy neutrino source
For the first time, scientists have traced back a high-energy neutrino to its source in space. It was produced by a so-called blazar—a supermassive black hole. Researchers from neutrino detector IceCube report this in Science. ‘This is a milestone for neutrino science,’ says physicist Dorothea Samtleben…
-
Freek Vonk gets his own show on Discovery Channel
Biologist Freek Vonk had already appeared in the Time Warp programme, where he was shown milking a snake for its venom, which he needed for his doctoral research. On Friday 18 September, he explained his fascination for snakes to Matthijs van Nieuwkerk in ‘De wereld draait door’, a Dutch news and entertainment…
-
Seeking new concepts to treat diseases
Scientific Director of the Leiden Academic Centre for Drug Research (LACDR) Hubertus Irth: ‘We test substances and look for new concepts for treating disease.’
-
Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
-
Cannabinoid receptor 2 as a ‘drugable’ target: kinetic profile of novel receptor ligands
Supervisor: Andrea Martella
-
Ensnaring tumours in their own web
Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.
-
EUFEPS congres
EUFEPS Women in Pharmaceutical Sciences Award for Jara Bouma
-
Bioactive Molecules
Bioactive Molecules is one of the four research themes of the Institute of Biology Leiden.
-
Dr. Gerard van Westen receives VENI grant
Gerard van Westen (LACDR/division of medicinal chemistry) has been awarded with a VENI grant from NWO, the Dutch Research Council.
-
To explore the drug space smarter: Artificial intelligence in drug design for G protein-coupled receptors
PhD defence
-
Centre for Interdisciplinary Genome Research
The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.
-
3 October University: from Russian DNA to drug-related violence
In prehistoric times there was a huge wave of migration, from the steppes in Russia and Ukraine to West Europe. The newcomers’ genes began to dominate. Archaeology research in Leiden into burial mounds in the Veluwe and Utrechtse Heuvelrug areas of the Netherlands yielded this spectacular conclusion.…
-
Will this discovery help us develop better catalysts?
Where exactly on the surface of a catalyst do the chemical reactions occur? Until now, it has always been a challenge to identify the exact locations of these ‘active sites’. In a new article in Nature, Leiden chemists helped their international colleagues reveal new insights into this issue. Their…
-
High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
-
Sebastian Pomplun joins Oncode Institute to accelerate breakthroughs in cancer research
Sebastian Pomplun manages to reach proteins with drugs even where this was thought impossible. That is why he and his research group have been allowed to join Oncode Institute. With nine others, he had been selected from 72 applicants to contribute to Oncode Institute's mission: to accelerate breakthroughs…
-
Review paper on the potential impact drug-metabolizing enzymes on brain exposure
PhD candidate Mengxu Zhang (Division of Systems Pharmacology and Pharmacy) published a comprehensive and important review on “The potential impact of CYP and UGT drug-metabolizing enzymes on brain target site drug exposure” in Drug Metabolism Reviews.
-
Developing metabolomics for a systems biology approach to understand Parkinson's disease
Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…
-
Unlocking the potential of small molecules in cancer therapy
How can we translate more fundamental discoveries into clinical solutions for patients? From that question, the Oncode Accelerator programme emerged. Professor of Molecular Physiology Mario van der Stelt has been one of the driving forces behind it since its inception. In an interview on the website…
-
PhD Research || Re-discovery of the Italian salterio
It was her original Salterio from 1725, built by Michele Barbi, which Franziska Fleischanderl could coincidentally acquire in 2014 that ignited her passion for this special string instrument. Before, she was focussed on contemporary music with modern Hackbrett.
-
Marieke Liem in The Economist on drug-related murders in Europe
Marieke Liem, professor at ISGA, discusses how the number of drug-related murders has not decreased in the last years