1,371 search results for “ancient dna” in the Public website
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spFRET studies of nucleosome dynamics modulated by histone modifications, histone variants and neighboring nucleosomes
Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort
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Chromatin organization & dynamics (Dr. Remus Dame)
Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…
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European roadmap for graphene applications in science and technology
More than 60 European researchers and industry partners have set out their roadmap for the application of graphene in marketed products. Leiden chemist Grégory F. Schneider believes that graphene and other layered materials can in the future be used for DNA sequencing applications.
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Structural changes in single chromatin fibers induced by tension and torsion
Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort
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DNA-Decorated soft nanostructures from the self-assembly of DNA amphiphiles
Lecture
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Ancient Roman cuisine was varied, international and accessible to all social classes
Banquets for the rich, porridge for the poor and a standard diet of bread, olive oil and wine. Just a few assumptions about the Roman diet.
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NWO ECHO grant for research on fickle RNA production
Genes are active sometimes, and other times they remain dormant for a while. Leiden physicist John van Noort receives an NWO ECHO grant to find out how this happens.
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Unspinning chromatin: molecular mechanisms of chromatin remodeling
How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?
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Measuring water life
Human activity, such as pollution, may disturb the balance of living water systems, which has consequences for biodiversity, but also for other functions such as water purification. Leiden University maps living water systems using the most advanced technologies.
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A Descriptive grammar of Sumerian
This grammar describes Sumerian, an ancient Near Eastern language which was spoken in what is now southern Iraq, on the basis of written sources dating from about 2500 to 2000 BC.
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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John van Noort Lab - Chromatin Dynamics
Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.
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The writing on the rocks: Thamidic and Arabia's linguistic past
This project aims to open up the pre-Islamic linguistic history of Arabia through the systematic study of the Thamudic inscriptions within a digital humanities framework.
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Thy Name is Deer. Animal Names in Semitic Onomastics and Name- Giving Traditions: Evidence from Akkadian, Northwest Semitic, and Arabic
Hekmat Dirbas defended his thesis on 14 February 2017
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Shaping proteins to understand chaperone-related diseases
Alireza Mashaghi and his research team have created a new framework to understand shapes of proteins and DNA. With this framework, many diseases can be understood better.
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Layers of dental tartar
Bacteria in the teeth tell us a lot about nutrition and disease in our ancestors. It also tells us more about the immune system. This provides clues for treating modern diseases and allergies. For a long time archaeologists were irritated by tartar on the teeth of excavated skulls. They thought that…
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Chromatin organisation & dynamics
The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…
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Urbanism and municipal administration in Roman North Africa
This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.
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Greater focus on pre-Islamic heritage
War and terrorism overshadow interest in the pre-Islamic heritage of the Arabic peninsula. The new Leiden Centre for the Study of Ancient Arabia aims to make the general public more aware of the ancient history of this region.
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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New open access, peer-reviewed journal: Arabian Epigraphic Notes
The Leiden Center for the Study of Ancient Arabia (LeiCenSAA) announces a new open access, peer-reviewed journal dedicated to the epigraphy of Arabia and its cultural and linguistic context: Arabian Epigraphic Notes
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The reconstruction of the codex Añute palimpsest using hyperspectral imaging data
A technique originally developed for satellite imaging can now be used to recover pictographic texts from underneath the surface of a five hundred year old Mexican manuscript.
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Cancer and heredity
Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.
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Participants
The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).
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Urban Craftsmen and Traders in the Roman World
This volume, featuring sixteen contributions from leading Roman historians and archaeologists, sheds new light on approaches to the economic history of urban craftsmen and traders in the Roman world, with a particular emphasis on the imperial period.
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Re-assessing the environmental impact of early Roman expansion
This project aims to explore the environmental impact of early Roman expansion (4th/3rd century BC) through a program of dating and ecological sampling of traces of field systems (centuriations).
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The Long Arab Conquest of Central Asia: Urban Change in Merv, Paikent, Balkh and Samarkand (651-821)
This PhD research aims to trace the impact of the Arab conquest, both immediate and long-term, on the material and social organization of Central Asia from 651 to 821 through an “urban change” perspective in four cities: Merv, Paikent, Balkh and Samarkand.
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The Archaeology of Greater Nicoya
Two Decades of Research in Nicaragua and Costa Rica
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Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
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New generation of graphene biosensors based on smooth surfaces and sharp edges
The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…
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The development of the Proto-Indo-European syllabic liquids in Greek
Ancient Greek was spoken in a large number of different dialects. Although we do not find direct evidence for syllabic liquids in any of our sources, comparative evidence shows that these sounds must have been present in Proto-Greek, and that they were retained until comparatively recently in the prehistory…
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Introducing: Pieter Houten
Pieter Houten is a PhD student in the ERC granted research project 'An Empire of 2000 Cities: urban networks and economic integration in the Roman empire', directed by Luuk De Ligt and John Bintliff (Archaeology).
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First patient in the Netherlands successfully treated with stem cell gene therapy
Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…
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Key publications
Key research articles and book chapters of the Chromatin group.
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High fidelity DNA replication and repair
PhD defence
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Alessandro Aleo
Faculteit Archeologie
a.aleo@arch.leidenuniv.nl | +31 71 527 2727
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Yuye Que
Faculty of Humanities
y.que@hum.leidenuniv.nl | +31 71 527 1514
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Luuk de Ligt
Faculty of Humanities
l.de.ligt@hum.leidenuniv.nl | +31 71 527 2669
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Nico Staring
Faculty of Humanities
n.t.b.staring@hum.leidenuniv.nl | +31 71 527 2727
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Ruurd Halbertsma
Faculty of Humanities
r.b.halbertsma@hum.leidenuniv.nl | +31 71 527 2727
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Valentina Azzarà
Faculteit Archeologie
v.m.azzara@arch.leidenuniv.nl | +31 71 527 2727
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Gerard Versluis
Faculteit Rechtsgeleerdheid
g.h.a.versluis@law.leidenuniv.nl | +31 71 527 8515
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Annelou van Gijn
Faculteit Archeologie
a.l.van.gijn@arch.leidenuniv.nl | +31 71 527 2389
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Michael Kerschner
Faculteit Archeologie
m.kerschner@arch.leidenuniv.nl | +31 71 527 2727
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Efficient targeting of the Trichoderma genome for industrial protein engineering
The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.
- Laboratory for Ceramics Studies
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Moving Romans. Migration to Rome in the Principate.
Moving Romans offers an analysis of Roman migration by applying general insights, models and theories from the field of migration history.
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Fighting tumours with light
Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.
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The researchers
Professor of Ecotoxicology Martina Vijver and lecturer Maarten Schrama are the founders and managers of the Living Lab. As well as these two researchers, a number of other ecologists and biologists are involved in the research at the Lab.
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Quantifying nucleosome dynamicsand protein binding with PIE-FCCS and spFRET
In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…