2,262 search results for “mexican drug violence” in the Public website
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Artificial intelligence as the co-pilot for drug discovery
There are more molecules that could conceivably be candidate drugs than there are stars in the universe. How can we ever efficiently identify those molecules? Professor of AI and Medicinal Chemistry, Gerard van Westen: ‘I’m going to use artificial intelligence as the co-pilot to make an automated search.’…
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Predicting drug behaviour in the brain
Does a drug enter into the human brain once administered in the body?
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Experimental drug BIA 10-2474 deactivates proteins in human nerve cells
At high doses, drug candidate BIA 10-2474 binds not only to the protein that it targets, but to other proteins as well. It thus deactivates proteins that are involved in the metabolism of nerve cells. This is what an international group of researchers from Leiden University and Erasmus MC, among others,…
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Drugging the undruggable: NWO Open Competition grant for Alireza Mashaghi
Finding structure in disordered proteins and developing drugs for undruggable diseases: it might sound like mission impossible, but pharmacologist Alireza Mashaghi and his team are right on top of it. Their project was awarded by NWO through the Open Competition Domain Science -XS, a competition that…
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Combatting violence against children: what are the lessons learnt?
In the context of the 2021 Day of General Discussion of the UN Committee on Rights of the Child, this time dedicated to alternative care, Defence for Children in collaboration with Leiden University has contributed with a paper on the 2019 Dutch Inquiry Committee on Historical Child Abuse in Alternative…
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Orange the World: Visible and invisible violence against women
On 25 November, the global 16-day campaign 'Orange the World' against violence against women and girls started. Leiden University will also be paying attention to this campaign. On Friday 9 December, Renate van der Zee and Marieke Liem will give a lecture at the Campus The Hague (Spanish Steps, Wijnhaven)…
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Proving discriminatory violence at the European Court of Human Rights
On Tuesday 23 May 2017, Jasmina Mackic will defend her doctoral thesis ‘Proving discriminatory violence at the European Court of Human Rights’. The defence will start at 15.00 hrs, at the Academy Building of Leiden University, Rapenburg 73. The supervisor of the research is Vice Dean and Professor of…
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Psychologist writes sober book about psychedelic drugs
Psychedelic drugs like magic mushrooms and LSD are embraced by some and seen as lethal by others. Cognitive psychologist Michiel van Elk delved into the world of psychedelic drugs and wrote a surprisingly sober book about them. ‘Without first-hand experience my story wouldn’t be complete.’
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Academy Building ‘oranged’ to stop violence against women
Eliminate violence against women. That is the message of the Orange the World campaign. Leiden University is joining in this year, hence the ‘oranged’ Academy Building and Oude UB.
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Leiden University signs Amnesty manifesto against sexual violence
Leiden University signed the Amnesty International ‘Let’s talk about YES’ manifesto on 10 March, confirming the university’s commitment to preventing sexual violence. Steps will also be taken to make sure that everyone within the university feels responsible for a culture in which sex is based on equality…
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From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
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market needs: new course for master’s students focuses on quality in drug development
Immediately connect with the needs of industry with your master’s degree. The new course Practical Aspects of Quality Management in Pharma and Biotech provides just that. The LACDR and LUMC set up the course together with the Biotech Training Facility, located at the Leiden Bio Science Park. The first…
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NMR Facility
Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…
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From scientific idea to promising new drug
Many pharmaceutical companies no longer have their own lab and are working more closely with universities and start-ups of scientists. Professor of Science-Based Business Simcha Jong is researching how scientific ideas result in new drugs, including at the Leiden Bio Science Park (LBSP).
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Leiden based research confirms systematic and excessive violence in Indonesia
New research has confirmed that the Dutch military used systematic, extreme violence against Indonesians. In his book Soldaat in Indonesië (Soldier in Indonesia), to be released at the end of October, historian Gert Oostindie draws the same conclusions using different sources. He presents new findings…
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Career Foreign Fighters: Expertise Transmission Across Insurgencies
Jeanine de Roy van Zuijdewijn, Chelsea Daymon and David Malet, wrote RESOLVE Network Research Report that examines career foreign fighters who have traversed from one insurgency to another.
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Drone imagery in Islamic State propaganda: flying like a state
This article provides a comprehensive analysis of the Islamic State's use of images taken by drones, drawing on a dataset of ISIS propaganda images from October 2016 to December 2018.
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ZonMw grant for research on domestic violence family treatment
Although domestic violence often affects multiple family members, parents and children are usually treated separately for their traumatic experiences. In collaboration with women's shelter Rosa Manus, forensic partner the Waag, the municipality of Leiden and their colleagues from LUBEC (Leiden University…
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Oncode Accelerator launched: patients at the centre of innovative cancer drug development
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process.
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Parameter optimization toward optimal microneedle-based dermal vaccination
Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.
- Blog Posts
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Bioprinting human tissues for drug testing
Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…
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Cells with stress: predicting drug-induced liver and kidney damage
How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.
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Laura Heitman
Science
l.h.heitman@lacdr.leidenuniv.nl | +31 71 527 4558
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Juan Masullo Jimenez
Faculteit der Sociale Wetenschappen
j.masullo@fsw.leidenuniv.nl | +31 70 800 3879
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The Mesoamerican codex re-entangled: Production, use, and re-use of precolonial documents
This dissertation is concerned with the study of the less than twenty remaining precolonial Mesoamerican codices. By considering these rare and fragile pictographic and hieroglyphic books from the cultural biography perspective, many different aspects of these books can be studied.
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Professor Mariëlle Bruning elected Member of the Expert Group Violence Against Children of the Council of Europe (2018-2019)
Mariëlle Bruning, Professor of Child Law, is elected Member of the Expert Group on Responses to violence against children (CAHENF-VAC), which is established to assist the Ad hoc Committee for the Rights of the Child (CAHENF) of the Council of Europe.
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De Witte et al publish in Nature Drug Discovery Reviews
Nature Reviews Drug Discovery volume 18, pages 82–84 (2019). The implications of target saturation for the use of drug–target residence time Wilbert de Witte, Meindert Danhof, Piet van der Graaf, and Elizabeth de Lange
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INSIGHT: focus on the way in which firearms are related to firearms violence
The European Commission awarded the project proposal INSIGHT, a follow-up project on illegal firearms trafficking and gun violence from Professor Social Resilience and Security Marieke Liem and PhD-researcher Katharina Krüsselmann of the Institute of Security and Global Affairs (ISGA).
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The chemistry behind cancer drugs: searching for fewer side effects
PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…
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Drug discovery 3.0: more effective and humane
Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.
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Impurities in sugar excipients could cause drugs to fail
Sugar excipients, needed to stabilize medicines, can be unsafe for patients due to an impurity discovered recently by Daniel Weinbuch. ‘The biopharmaceutical industry should now consider new excipient quality criteria for safer drug development,’ he says. PhD defence on 13 December.
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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Gut-on-chip good predictor of drug side-effects
Research conducted at Leiden has established that guts-on-chips respond in the same way to aspirin as real human organs do. This is a sign that these model organs are good predictors of the effect of medical drugs on the human body. Publication in Nature Communications on 15 August.
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Sensing drug responses of single cells using optical tweezers
Light can be used to apply forces on single cells. Focused lasers have been used by physicists to tweeze particles and to manipulate them. These so called “optical tweezers” can be used as mechanical phenotyping tools for characterising the mechanics of materials and living objects.
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Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and space. Vendel…
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Drug development: how can we make it more efficient?
It takes years to develop new medicines, from the test tube to trials in humans. During the process it often happens that a drug that seems promising in the initial stage has to be dropped in a later phase. This costs time and money. Leiden University and the LUMC are working closely together to make…
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New project uses artificial intelligence in drug development
In health care, artificial intelligence is quite normal: it is used, for example, as an aid in making diagnoses. However, artificial intelligence is not yet used as much in drug development. A new prestigious partnership is therefore going to investigate how artificial intelligence can contribute to…
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Countering nerve pain caused by chemotherapy with new drug
Nerve pain is one of the most common side effects of chemotherapy. It is therefore one of the biggest reasons for cancer patients to stop treatment early. Darcy Reynolds worked on new drug candidates against this pain during her bachelor's thesis. She developed a new series of molecules that increase…
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How Leiden's drug pioneers have switched to Covid research
From studying molecules in the blood of corona patients to developing a new concept for vaccines. The Leiden Academic Centre for Drug Research (LACDR) has transformed many ongoing projects into Covid research projects. Hubertus Irth, scientific director of LACDR, talks about the role of his institute…
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Monitoring Cytoskeletal Conductance Variation for Sensing Cancer Drug Resistance
Actin and microtubules form cellular cytoskeletal network, which mediates cell shape, motility and proliferation and are key targets for cancer therapy. Changes in cytoskeletal organization correlate with proliferative capacity and invasiveness of cancer cells. These changes expectedly lead to altered…
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Erik Danen appointed as Professor of Cancer drug target discovery
As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
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How drugs work better when encapsulated in nanoparticles
Chemist Tobias Bauer discovered ways to improve drugs by encapsulating them. Packages with iron nanoparticles, for example, can stimulate immune cells. Bauer will receive his PhD on 9 June.
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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The body's own marijuana as inspiration for drug research
Endocannabinoids - the body's own marijuana - are promising departure points for drug research. Professor of Molecular Physiology Mario van der Stelt examines whether inhibiting their production can be a way to fight inflammatory brain disease and to combat obesity. Inaugural lecture 19 October.
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Innovation centre for drug development on Bio Science Park
International pharmaceuticals company Grünenthal is to open an innovation hub on the Leiden Bio Science Park. The hub will make it easier for scientists and drug developers to work together.
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Interdisciplinary minor ’Violence Studies’: ‘It felt like we were going to fight a group of people’
The interdisciplinary, English-taught minor ‘Violence Studies’ looks at violence from very diverse scientific perspectives. What are the benefits from this approach? Students and lecturers evaluate: ‘This minor’s a goldmine’.
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Dutch people are understanding the term ‘violence’ to mean more and more
When do we say violence was used in an incident? The answer may seem obvious at first. But interim results from a study by Jolien van Breen show that Dutch people are labelling events in increasingly broad contexts as violent.