Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

In this thesis, we study different curved single crystals because of the diversity of surface structures across their curvature.

Green hydrogen is produced via a process called water electrolysis. During electrolysis water is split into oxygen and hydrogen.

Promotor: A. Kros

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

The overall theme of this thesis is to complement the electrochemical data acquired in fuel cell research with in situ X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS).

Lecture

This thesis investigates catalytic reactions at the atomic scale using scanning tunneling microscopy (STM), with a focus on Fischer–Tropsch synthesis, a key industrial process that converts hydrogen and carbon monoxide into liquid fuels.

Lecture

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit and chemist Hermen Overkleeft.

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

The Novel chemical modalities research group is headed by Assistant Professor Sebastian Pomplun. Sebastian started at the division of Medicinal Chemistry within the LACDR in September 2021. His lab develops technologies for the discovery of novel chemical modalities that can address challenging drug…

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This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

Source: ChemMedChem (2015)

Contact Metals in Catalysis, Biomimetics & Inorganic Chemisrty

This thesis highlights the significant role of surface geometry and oxidation state in determining CO adsorption behavior on copper surfaces.

The CARICOM-MERCOSUR Chamber has confirmed its participation at the ‘Trade Beyond COVID-19: Building Resilience’, a public seminar organized by the World Trade Organization.

Conference

Central in coordination and organometallic chemistry is the synthesis of new chelating ligands, the synthesis and characterization of metal complexes with these ligands, and the study of their properties. An important goal in my research is to create understanding of the relation between the structures…

On Wednesday 12 December 2018, the department of Child Law, on the initiative of dr. Yannick van den Brink, dr. Stephanie Rap en prof. dr. Ton Liefaard), organized an expert meeting on ‘Equality, children’s rights and digital technologies’. The objective of the meeting was an in-depth exchange of ideas…

Are you interested in taking up an extra challenge during your master’s programme?

The European Project SUNRISE, ‘Solar energy for a circular economy’, has been selected as one of the six Coordination and Support Actions (CSA) within the Horizon 2020 programme of the European Commission. Funded with 1 million euros, it will set the base for a large scale European research project.…

How do protein modifications work together to repair DNA, and what can we learn about these interactions to better understand disease?

A European consortium has provided a disruptive technological breakthrough to allow the discovery and characterization of novel enzymes for industrial biotechnology. The technology will open the way to more efficient industrial processes such as in the biofuel, animal feed and paper and pulp industr…

The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…

Development & demonstration of low environmental impact innovation and optimization practices in pharma production.

best phd theses of the faculty of science Leiden - physics, chemistry, computer science, biopharmaceutical sciences, biology, industrial ecology, environmental sciences, astronomy, mathematics. thesis

In the programme NWO Open Competition Domain Science - GROOT, twenty new consortia will start a large research project. This boost of more than 47 million euros will make new research possible in the science domain. Among the winners is the Nanoscale Regulators of Photosynthesis consortium in which…

Professor Bert Meijer has been appointed to the Board of Governors of Leiden University by Minister of Education, Culture and Science Jet Bussemaker for a term of four years from 1 January 2017.

This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

This project aims at determining the market value of hydrogen peroxide (HP) that is produced via our electrochemical methods that have been developed as part of the ERC-StG Cu4Energy project.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Promotor: Prof.dr. J.P. Abrahams

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Promotor: M. Ubbink, Co-promotor: G. Siegal

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Hydrogen peroxide (H2O2) generation via electrochemical oxygen reduction is a sustainable production method for this bulk chemical. However, the selectivity of molecular catalysts for electrochemical H2O2 generation has hardly been investigated in a systematic manner, and it is unknown if their stability…

Promotor: Prof.dr. M. Ubbink

We report new computational and experimental evidence of an efficient and astrochemically relevant formation route to formaldehyde (H2CO). This simplest carbonylic compound is central to the formation of complex organics in cold interstellar clouds and is generally regarded to be formed by the hydrogenation…