To inhibit proteins that contribute to the growth of aggressive cancer cells, that’s the plan of Professor Bob van de Water and his team. They will receive over 700,000 euros from the KWF Dutch Cancer Society for their research. Researcher Maaike Vreeswijk and pathologist Danielle Cohen are affiliated…

On 7 December, Armin Cuyvers (Assistant Professor at the Europa Institute) gave a lecture on the legal complications surrounding Brexit for Mordenate College.

On 8 November 2017, The Law Societies Joint Brussels Office of the UK organised a seminar on the subject of ‘Brexit: Where & How to Enforce: Building Blocks for a New Dispute Settlement System’. The seminar was held in the building of the European Parliament in Brussels.

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

Promotores: Wim Jiskoot; Ferry Ossendorp

In breast cancer, metastasis rather than the primary tumour is the cause of death. A lack of oxygen in the tumour cells promotes this metastasis, accompanied by a reprogramming of the cell's metabolism. PhD candidate Qiuyu Liu investigated these alterations to get more knowledge about the actionable…

In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.

Armin Cuyvers was interviewed for the weekly science page of local newspaper Leidsch Dagblad, about Brexit and its legal complications in relation to Norther Ireland.

On 18 October, Armin Cuyvers, Associate Professor of European Law at the Europa Instituut, spoke at the Law School of Sydney University on reconciling political drama and legal realities in Brexit.

In the last few weeks Armin Cuyvers was several times in the news on Brexit. He was a studio guest during the new years episode of Legal Affairs on BNR national radio and he was a studio guest in the news programme EenVandaag.

The Common Market Law Review is proud to present a Special Issue on legal issues relating to Brexit following the lustrum conference on Brexit and the Future of the European Union that was held in Leiden in 2017 to mark the 60th Anniversary of the Europa Institute of Leiden University.

On 11 November, Armin Cuyvers, Assistant Professor at the Europa Institute in Leiden, was one of the speakers on Brexit during the autumn meeting of the Netherlands Association for European Law (NVER).

The August issue of the CML Rev., Vol. 53 No. 4, is now available online.

On 1 and 2 November 2018 Armin Cuyvers and Daniel Carter presented two papers during a LERU conference on the Implications of Brexit: EU and Post-EU Constitutional and Substantive Law.

Following the European Union membership referendum in the United Kingdom on 23rd of June 2016 and its result, Brexit has turned into a theme dominating public discussion in Europe and beyond.

On 20 June, Armin Cuyvers was invited to speak at the Riga Graduate School of law during the concluding conference of their Jean Monnet project on fundamental rights at the frontiers of the European Union – looking for a new balance.

On Thursday 12 December, the day of the UK general election, Armin Cuyvers was interviewed by BNR Nieuwsradio.

Last week Saturday LUC hosted a Symposium about Brexit for students and alumni. Many interesting perspectives were shared by the speakers, as well as comments and questions from the public.

The immune system plays a paradoxical role in the spread of breast cancer. Some immune cells contribute to metastasis, while other cells can be activated to strengthen the effect of chemotherapy. Kelly Kersten made this discovery in her PhD research. PhD defence 7 February.

Lecture

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by molecular cell biologist Claudia Tulotta. PhD defence 14 June.

On Tuesday June 14th, Dr. Armin Cuyvers of Leiden Law School discussed the legal consequences of a possible Brexit in the radio program Juridische Zaken (Legal Matters) of Business News Radio (BNR).

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

What happens if a Member State decides to withdraw from the European Union? The “Brexit Charts” aim to provide information on the withdrawal procedure under Art. 50 TEU, on the legal consequences of leaving the EU and on the future relationship of the withdrawing state with the European Union.

On 1 February 2017 there was a hearing in the committee on European affairs of the second chamber of the Dutch Parliament on the issue of

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Now that a Brexit agreement has been reached, envy is rearing its ugly head among Swiss politicians. This envy is not only rooted in reluctance towards the European Court of Justice or having to accept EU rules. It also comes from the fact that for some time now many Swiss believe that the current bilateral…

How can the United Kingdom find coalitions for a Brexit? Alexandre Afonso, Assistant Professor at the Institute for Public Administration, analysed how the Members of Parliament voted up to now and presents a graph with possible coalitions on several withdrawal agreements. The article is published in…

The potential of liposomal cancer vaccines

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Cancer is still one of the most common diseases in the world. What exactly is cancer and will we one day be able to cure everyone? In a video from the Universiteit van Nederland Noel de Miranda (Tumour Immunology, LUMC) tells you about his research on new treatments.

Promotores: W. Jiskoot, F. Ossendorp

At the time of writing, the UK has just acquired an extension for their departure from the European Union. However, this had not been the case when LUC’s ‘Regional Trends: The EU and its Neighbourhood’ class visited the Irish Embassy on Wednesday 20th March; at this point, everyone was preparing for…

Brexit has been a kind of shock therapy for the EU and has eventually led to more appreciation for European cooperation. That is what Professor Luuk van Middelaar claimed on 30 November at the conference ‘Brexit and the future of the European Union’ which marked the 60th anniversary of the Europa Institute…

What are the scenarios now the draft Brexit Agreement is on the table? And if the United Kingdom actually proceeds to leave the European Union, what is the time frame? Associate Professor of European Law Armin Cuyvers sheds light on the current state of affairs.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

New Brexit publication of Christa Tobler, Professor of European Law at the Universities of Basel (Switzerland) and Leiden, on the protection of acquired rights: ‘After ‘BREXIT’.

The British House of Commons International Trade Committee quoted Dr. Joris Larik, Assistant Professor of Comparative, EU and International Law at Leiden University College The Hague, in its report on the “Continuing application of EU trade agreements after Brexit”.

Winning a prestigious award for PhD researchers, even before you have your doctorate: that's what Yascha van den Berg managed to do with his research proposal on alternatively spliced tissue factor, a protein that may be involved in tumour growth. Van den Berg: ‘It all started as a Friday afternoon…

Joris Larik was interviewed by BBC World Service radio on the state of Brexit negotiations, the Irish border issue and ongoing Dutch preparation.