This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

This project is situated within the context of an innovation of the biology curriculum in Dutch secondary schools. The main purposes are (1) to clarify the relation between teachers’ practical knowledge and the decisions they make when planning and implementing their lessons and (2) to develop a professional…

As of 1 September, Jeroen van Zon started as professor by special appointment in Quantitative Developmental Biology at the Institute of Biology Leiden (IBL). Van Zon is also group leader of Quantitative Developmental Biology at the physics research institute AMOLF. Three questions about his new role…

FAIRDOM consortium is an open initiative of various partners including funding programmes, large-consortia, institutes, small groups as well as individuals.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

During post-embryonic development into adults, animals face an environment that fluctuates constantly. For example, in nutrient availability, temperature, and osmolarity (e.g., salt concentration).

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Paul Brakefield, Professor of Evolutionary Biology at the Institute of Biology in Leiden (IBL) has been awarded an ERC Advanced Grant for his research. He will receive 2.5 million euro to develop his research programme over a period of five years.

The European Union has invested ten million euros in the so-called iNEXT-Discovery consortium. The goal of this new consortium is to enable European researchers to extend innovative structural biology research. The Netherlands Centre for Electron Nanoscopy (NeCEN) is also part of iNEXT-Disovery, which…

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Roel Wouters (24), a biology student at Leiden University, is a finalist in the election for UN youth delegate for Biodiversity and Food. The digital polls open for a week on Friday 22 October. Under-30s can vote for Roel at www.stemroel.nl.

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.

A Vici grant and a Science-GROOT: scientists from the Institute of Biology Leiden have been awarded prestigious grants from the Dutch Research Council (NWO). From investigating bacteria without cell walls to harnessing plants with the help of microorganisms.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Developing a new way to measure marine biodiversity at high resolution, by listening to it.

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How do teachers’ knowledge, practices, perceptions, job satisfaction and workload in secondary education develop during a school innovation in the context of differentiated student development?

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Why does social anxiety increase in adolescence and how does it grow out of control in some adolescents?

Ariane Briegel has been appointed Professor in the fìeld of Ultrastructural Biology within the Faculty of Science at the Institute of Biology from the 1st of December 2015. Her expertise is in using electron cryotomography to study how microbes sense and respond to their environment.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

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On Monday the 8th of December, the annual symposium of the IBL will be organized at the main building of the LUMC Leiden. This year’s theme is “Integrative Biology towards Healthy Communities”.

Gijs van der Velden has one of the best study results in his first college year of all science studies. With that, he won the Young Talent Incentive award and received 500 euros of the Koninklijke Hollandse Maatschappij der Wetenschappen (KHMW). The biology student remains quite nonchalantly. ‘Of course,…

‘It was not always accepted, but I just wanted to be a researcher. Now, I am as happy as can be.’ It is one of the quotes from the International Women’s Day presentation for Biology students. Seven women, working as researchers and teachers at the CML, IBL, and Naturalis, shared their experiences with…