Who had a say in making decisions about the natural world, when, how and to what end? How were rights to natural resources established? How did communities handle environmental crises? And how did dealing with the environment have an impact on the power relations in communities?

Leiden University is aware of its role in society and wants to create a green, healthy and inclusive campus and have a positive impact on the field of climate and circularity.

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

Oxidation is a common degradation pathway that affects therapeutic proteins and peptides during production, purification, formulation, transportation, storage and handling of solid and liquid preparations. In the present work we review the scientific literature about structural and biological consequences…

The Computer Support group provides dedicated support for the computing infrastructure of Leiden Observatory

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Drought, exacerbated by climate change, is becoming a serious issue in Dutch cities. This affects the availability of water for people, nature, and infrastructure. The Thirsty Cities project is the first large-scale initiative to investigate this phenomenon, involving dozens of knowledge partners and…

The largest structures in the Universe are clusters of galaxies. Each can contain hundreds to thousands of galaxies.

Of jars and gongs deals with the traditional ritual art of Ot Danum Dayak subsistence farmers from a stretch of tropical rainforest in the heart of Borneo. Together with the Ngaju, their neighbours to the south, they gloried in one of the most elaborate secondary mortuary rites in the world.

In line with Leiden University's sustainability vision for 2030, the Green Office is taking practical steps to structurally integrate sustainability principles within the pillars of education and research. Central to this effort is the introduction of the Sustainable Master Thesis Award, which strives…

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

LIAS aims to advance the globally conscious vision of area studies, both within and outside the academic community. Focusing on Asia and the Middle East, the institute is a meeting place of multiple fields of inquiry, theories and methods, historical periods, and areas.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

Today, knowledge is the most crucial element to stimulate organizational competitiveness and economic development.

Considering the fact that for a long time women were not allowed to participate either in university life nor in academia, women found different ways they could be included.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Until 2019, LUCIS hosted one annual lecture, inviting an eminent scholar to give a large-scale lecture in one of the finer halls at Leiden University. Because of their success, we now organise four larger lectures every year, entitled LUCIS Keynotes.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

With this thesis the PhD-candidate aims to enrich the body of evidence concerning the relation between stress and health, and the mediating role of (un)conscious perseverative cognitions, which is captured in the extended perseverative cognition hypothesis.

Promotor: Prof.dr. E. R. Eliel, Co-Promotor: M.J.A. de Dood

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

The Campus Square, officially named Rosalind Franklin Square, is a green gathering place for students, staff, and city residents. It is a place where the university, businesses, and the city of Leiden come together.

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Promotor: Prof.dr. E.J.J. Groenen

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

On this page you will find all the practical services we offer you as an alumnus. This way you can continue to use the university libraries for the rest of your life and we will be happy to help you if you need proof of graduation for further education.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

Holidaymakers, day-trippers and tourists were able to book a University tour, with a student as their guide.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Leiden University offers more than 78 master's programmes in various fields taught in English. Tuition fees for master programmes range from 15,000 - 25,000 euros / year depending on the chosen study programme.

From Soledad Acosta de Samper and Albalucía Angel to Hazel Robinson Abrahams and Amalialú Posso Figueroa. During the Symposium & Workshop Experience and Voice: Library of Colombian Women Writers, Carolina Olarte-Bácares, Ambassador of Colombia, donates the Biblioteca de Escritoras Colombianas to the…

Promotor: Huub de Groot, Co-promotor: Francesco Buda

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Computer applications and quantitative methods in archaeology CAA95.

The Una Europa Clusters bring together leading experts and experienced staff from numerous academic and professional service departments across the Una Europa institutions.

Fake news is becoming more and more prominent now that social media allow for an endless stream of unfiltered content to reach us. But what happens if we can no longer distinguish the truth from the lie?