In Bronze Age Europe many bronze objects such as axes, swords and jewels were deliberately left at specific spots in the landscape. PhD research by Leiden archaeologist Marieke Visser shows that these practices were expressions of people’s relationship with the world around them. ‘It was a completely…

Density functional theory (DFT) with so-called semi-local exchange has been remarkable accurate for some dissociative chemisorption reactions on metals, but it has notoriously failed for others. A team of researchers from the University of California at Irvine and the Leiden Institute of Chemistry have…

A semi-empirical version of the specific reaction parameter approach to density functional theory (SRP-DFT) has been remarkably successful at predicting dissociative chemisorption probability vs. incidence energy curves for reactions on metal surfaces. New quantum Monte Carlo (QMC) calculations on the…

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

The IHL Clinic offers outstanding LLM candidates the chance to work pro bono on KGF projects and gain practical experience in humanitarian law in cooperation with practitioners working in the humanitarian field.

As of 1 May 2020 Maartje Schoorl holds the special chair 'Psychological Professional Training in Mental Health Care with emphasis on evidence based interventions'. Her appointment has been made possible by the Organisation of Postdoctoral Education Mental Health Care Leiden/Rotterdam for a period of…

The largest fertility clinic in the Netherlands lied to women, sperm donors, and the Health and Youth Care Inspectorate. On ‘Nieuwsuur’, Mirjam Sombroek van Doorm, Professor of Law and Health, foresees legal consequences: 'The situation is too serious.'

The global transition toward low-carbon energy systems and the rapid expansion of digital technologies, including artificial intelligence, are reshaping how modern societies produce, move, and process energy and information.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Bringing your drug candidates to patients is what many academic chemists dream about, but the road to this goal is long and bumpy. Now, Leiden small molecule nizubaglustat is ready for phase 3 clinical trials. This is thanks to a €132 million funding secured by the biotech spin-out Azafaros.

Anne Krause and Niki Antypa received a facultairy 'Grassroots' subsidy of 1.000 euros for education innovation. They're going to implement live supervision of students during therapy/coaching sessions in the International Practice Internship.

It is becoming increasingly clear that the placebo effect has a great influence on medical treatment. An international, interdisciplinary team of researchers led by Professor of Health Psychology Andrea Evers from Leiden University has now written a first set of guidelines on how to apply the placebo…

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

Krekels received both the Thesis Award and the TOP Publication Award for her thesis 'Size does matter: drug glucuronidation in children'. Her research led to a new dosage regimen of morphine for babies and toddlers. Both prizes were awarded during the scientific meeting of the NVKFB on Friday 11 Apr…

In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Most students of Psychology want to work in mental healthcare (GGZ). This makes the master’s specialisation in Clinical Psychology a logical choice. It was an option for alumna Ruth van Vugt for a long time, but she decided to explore further and has since successfully completed the Health and Medical…

On 6-7 November 2015, four members of the International Humanitarian Law Clinic of the Kalshoven-Gieskes Forum flew to Berlin to attend the 4th Annual Alumni Meeting of one of the clinic’s cooperation partners, the European Center for Constitutional and Human Rights (ECCHR).

On 16- 20 November 2015, the four members of the spring-semester International Humanitarian Law Clinic of the Kalshoven-Gieskes forum attended the RIPE71 Conference on Internet-related issues in Bucharest, Romania.

To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.

NWO has awarded a €392k Projectruimte grant to physicists Koenraad Schalm and Jan Zaanen to study ‘strange metals’. These materials are alleged to follow the bizarre laws of quantum mechanics even at everyday length scales.

A new class of polymers has been used in patients for the first time. The compound is the first new drug solubilising agent in decades. Introduced in 2014 by chemist Matthias Barz from Leiden University, it offers a unique alternative to current options.

PhD defence

A full overview of THEOR PhD theses.

Research at the MCBIM group is comprised of the following research themes:

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

On Thursday, 17 September 2015, the latest project of the Leiden International Humanitarian Law Clinic (the IHL Clinic) on ‘Principles of International Humanitarian Law applied to Cyber Warfare’ was concluded and presented to the Netherlands Red Cross.

Metal-organic compounds hold great promise as photoactivated chemotherapy (PACT) agents, leveraging their unique geometric and electronic properties to achieve precise spatiotemporal control over drug activation.

Chemical reactions go hand-in-hand with an energy exchange with the environment in which they take place. Surfaces offer a variety of energy dissipation channels, constituted by the nuclear and electronic degrees of freedom of the atoms at the interface. Aiming at an improved future harvesting of energy,…

This perspective addresses four challenges facing theorists whose aim is to make quantitatively accurate predictions for reactions of molecules on metal surfaces, and suggests ways of meeting these challenges, focusing on dissociative chemisorption reactions of H2, N2, and CH4.

The main goal of the THEOR CHEM group, headed by Prof. Geert-Jan Kroes, is to characterize, and to accurately predict the outcome of chemical reactions at gas-solid and liquid-solid interfaces. Here the solid surface is typically a metal or an ice surface. These goals are important to many areas in…

Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).

Research at the THEOR group is comprised of the following research themes:

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

Promotor: J. Schaye

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

A new app provides dynamic predictions of survival for patients suffering from soft tissue sarcoma. It was developed by the mathematical Institute research group DASPO, Data Analysis and Survival for Personalised Oncology.