This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

On the 15th of July Sawako Takemura successfully defended a doctoral thesis and graduated.

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

What are the precise identities, possibilities and current practice examples of the various time frames in music and what bearings do they have individually and in combinations on the speed of the music?

Promotor: E.F. Smets Co-promotor: J. Geml

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Psychologist Bernadet Klaassens initiated a large fMRI study on the effect of drugs on brain networks in aging and Alzheimer's disease. It generated a unique data set and insight into a new method to develop drugs for patients with Alzheimer's.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

The aim of this thesis was to study the link between hearing loss, language skills, and social functioning in deaf and hard of hearing (DHH) children. Sufficient language skills are an essential prerequisite to develop appropriate communication skills, in order to join in conversations with others.…

This study is the first to directly relate brain development to sex differences and school performance. The results debunk the myth that brain development is slower in boys.

The outermost layer of the skin, the stratum corneum (SC), is responsible for the skin barrier function, protecting the body from pathogens, chemicals and other unwanted substances from the external environment. The SC lipid matrix provides the only continuous pathway through the SC and is considered…

To what end and how does Plautus constantly underline the Helleni(sti)c provenance of his art? How does this aspect relate the author’s originality?

To argue that people can control the relative contributions of goal-driven and stimulus-driven processes to decision-making and action selection.

Form and Function in Greek Grammar. Linguistic Contributions to the Study of Greek Literature is a new book, written by Albert Rijksbaron. Rijksbaron is internationally known as one of the leading scholars of the Ancient Greek language, whose work has exerted a strong and lasting influence on the scholarly…

On the 20th of June, Camil Staps successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Camil on this achievement!

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

PhD defence

Promotor: G.R. de Snoo

Fatemeh (Simin) Tabassi Mofrad has recently received a project grant (€ 25,000) from LUF/Gratama Foundation for her ideas in investigating sex-by-genotype interactions in brain functions. She has a multidisciplinary research perspective which enables her to look at research issues from different angles.…

An international partnership of brain researchers from 35 research centres - from the US to China - including the Leiden Institute for Brain and Cognition (LIBC), has collected resting-state functional MRI data from more than 1400 healthy volunteers and put the information online so that it is available…

Are disturbances to the brain, such as Alzheimer's or autism, linked to specific defects in the underlying communication networks in the brain? If this is the case, subtle changes in the networks can act as a marker for brain disturbances. Neuroscientist Serge Rombouts will be investigating this, together…

Within the field of astronomy, understanding how galaxies grow and evolve from the Big Bang to the present day is a challenging and complex question.

In this thesis, deep learning is studied from a statistical perspective. Convergence rates for the worst case risk bounds of neural network estimators are obtained in the classification, density estimation and linear regression model.

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

Although plant domestication has significantly altered crop genetics and phenotypes, its effects on the taxonomic and functional diversity of plant-associated microbiomes are not well understood.

This project incorporates spatiality into the discussion of medieval demography, allowing for a more nuanced view on medieval town populations. It establishes a maximum population count for towns for periods prior to 1400 and provides a means to compare the ranking of towns using size and density instead…

Which plant leaf characteristics are involved in thrips resistance in tomato?

In this thesis, Quantum computing, norms, and polynomials, we investigate the interplay between quantum mechanics, complexity theory, and functional analysis, three central areas of physics, computer science, and mathematics, respectively.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

The functionality to log in to multiple services has been fully restored after a brief interruption.

This thesis contains results on the arithmetic and geometry of del Pezzo surfaces of degree 1.In Chapter 1 we give the necessary background, assuming the reader is familiar with algebraic geometry.

Source: British Journal of Dermatology, Volume 170, Number 6, pp. E18-E19 (2014) ISBN:0007-0963

Together with a large international team of scientists, researchers Peter van Bodegom and Nadia Soudzilovskaia of the Leiden Institute of Environmental Sciences (CML) have created maps of variability in plant trait distribution across the globe. The new maps have been published in Proceedings of the…

PURPOSE: To monitor the biodistribution of IgG1 aggregates upon subcutaneous (SC) and intravenous (IV) administration in mice and measure their propensity to stimulate an early immune response.

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

Promotores: P. Stevenhagen, E. Fouvry (Univeriste Paris Saclay)

One of the most important correlation functions in physics, especially in cosmology, is the energy density, which describes how much energy is present at each point in spacetime due to matter fields. A key contribution to the energy density of the primordial universe comes from gravitational waves (GWs),…

A full overview of THEOR PhD theses.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

This work is dedicated to interpreting in cohomological terms the special values of zeta functions of arithmetic schemes.

Mycorrhizas are symbiotic associations between soil fungi and most plant species.

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

The aim of the project is to unravel the genetic and contact relations between the indigenous languages of Mesoamerica (Mexico and western Central America) and the Middle Andes region (Ecuador, Peru, Bolivia), as part of a larger endeavor to understand the historical process of the peopling of the Americas…

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.