Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

Could we stop cancer cells by cutting off their energy supply? That’s what Dione Blok, a bachelor’s student in Bio-Pharmaceutical Sciences, aimed to find out during her thesis research. She investigated a compound that affects the tumour cells’ energy metabolism. ‘Hopefully, these insights will provide…

Drs. Bart Lenselink won the oral presentation at the LACDR Spring Symposium with his presentation “Predicting Drug Potency”.

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

The Netherlands sees thorny dilemmas placed with regard to the conviction of returning IS fighters. The Netherlands, like the other EU member states, does not respond to the Kurds' wish to take back 'their' Syrian people. Bart Schuurman, terrorism expert, states that an international tribunal, flanked…

Professor Jan-Bart Gewald has been appointed as the new director of the African Studies Centre in Leiden with effect from 1 September 2017, for a period of five years. Professor Gewald will succeed Ton Dietz, who will be retiring in September.

Promotor: Prof.dr. B. van de Water, Co-promotores: J.W. van der Laan, C.L.E. Siezen

How do cells repair their damaged DNA—and what happens when that process is hindered and cancer arises? Sarah Moser has taken a closer look during her PhD, uncovering surprising insights that could help improve future cancer treatments.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

As part of the HTSM2017 funding program, the LACDR division for Systems Biomedicine and Pharmacology received 1.08 million euros for a research project to develop novel engineering approaches to fight cancer.

As of 1 July 2019, Bart Custers is appointed as Professor of Law and Data Science at Leiden University. The chair is established at eLaw, the center for Law and Digital Technologies at the Faculty of Law. Bart Custers will focus on the intersection of law and digital technologies, on the one hand on…

On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…

Research at the Leiden University Medical Center (LUMC) Department of Pathology shows the power of artificial intelligence (AI) applied to endometrial carcinoma microscopy images. The group of Dr. Tjalling Bosse offers novel insights that could improve diagnosis and treatment of uterine cancer. Their…

As of 1 September Jan-Bart Gewald has been appointed as Professor of Southern African History in the Leiden Institute for History, in conjunction with the African Studies Centre, Leiden.

The book “Becoming a European Homegrown Jihadist” of Dr. Bart Schuurman, Assistant Professor at Leiden University's Institute of Security and Global Affairs (ISGA), is published by Amsterdam University Press on 22 March 2018.

One used 3D cell models to study colorectal cancer, while the other used machine learning for more efficient blood donation. For these achievements, Marieke Vinkenoog and Simon Christian Hansmann were awarded the Krijn Rietveld Memorial Innovation Award on Tuesday 2 September.

The more data from cancer research we pool, the better we can search for new treatments. But how can we keep patient data safe when sharing it? Leiden researchers will tackle this challenge in a major European project.

Dr. Eduard Fosch-Villaronga and his supervisor Dr. Bart Custers received a Marie Skłodowska-Curie Action (MSCA) fund for research on legal and regulatory aspects of healthcare robot and artificial intelligence technologies.

Very little is known about the relationship between religion and the digital future. Bart Barendregt, Professor by special appointment Anthropology of Digital Diversity, is about to change that. He receives a Vici grant of 1.5 million euros from the NWO for his research project 'One between the Zeros,…

Marta Fiocco, professor in the Mathematical Institute, has received a grant for analysing data on chemotherapy in children suffering from leukaemia. The work involves developing and applying new statistical methods that will help determining the optimal dose of chemotherapy.

Ultimate beneficial owners (UBOs) of companies should have registered their information in the Dutch UBO register before 27 March 2022. The Dutch Minister of Finance saw no reason to postpone the deadline for registration, according to answers to parliamentary questions. In an article on the legal platform…

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

A new app is able to calculate personalised survival probabilities for patients suffering from soft tissue sarcoma. Doctors and patients can use the app to calculate personalised survival probabilities together. Mathematician Anja Rüten-Budde received her doctorate for her research into survival probability…

This study is important because it seeks to uncover whether clinicians' communication influences neurobiological and physiological outcomes for patients.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

When you think of physics, do you think only of complicated formulas? You’re not the only one. Therefore, every year, the Leiden Insitute of Physics organises the LION Image Award to show another side of physics: beautiful images about intriguing science. The winner of the 2022 photo competition captured…

Luca Giomi has the first results of his ERC consolidator grant. He discovered that epithelial cells move collectively but in different ways, depending on the scale you look at. It is hexatic at small scales, and becomes nematic at larger scales: it is a multiscale order. This collective movement of…

Half of all people with cancer in the Netherlands are aged 70 or older, and as the population continues to age, this number will only rise. Yet vulnerable older people with cancer are often overlooked, says PhD candidate Joosje Baltussen.

Promotores: Prof.dr. M.K. Richardson, Prof.dr. H.P. Spaink

Stilzitten doet alumnus Bart Jansen niet graag. Zo geeft hij les in onder meer Nederland, Maleisië en Curaçao, houdt hij zich naast het recht ook graag bezig met kunst en mystiek en vindt hij naar eigen zeggen ‘alles wat fout gaat’ wel interessant aan de rechtsfilosofie. ‘Ik ben gek op veelzijdige mensen;…

Legal philosopher Bart Jansen teaches at universities around the world. In an interview two years ago, he spoke about his professional fascination for dictators and wars. Since then, the world has undergone major changes. High time for a follow-up interview.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

Thirty years ago, mutations in the BRCA1 gene were first linked to hereditary breast and ovarian cancer, establishing a genetic basis for cancer development.

During illness, the stiffness or viscosity of cells can change. Tom Evers demonstrated this by measuring such properties of human immune cells for the first time. ‘The stiffness of certain cells could be a way to make a diagnosis,’ Evers said. He defended his thesis on March 26th.

On 14 April, the National Growth Fund awarded million euros in grants to two consortia in which Leiden's science faculty is involved. Pharma-NL will receive 80 million euros and Oncode-PACT 325 million euros. Pharma-NL wants to make medicines available to the patient faster and more sustainably. Oncode-PACT…

Bart Schuurman, Assistant Professor at the Institute of Security and Global Affairs, discusses the development of the exchange of letters between Mohammed B. and ‘prisoner X’ and the usefulness of a separate terrorist department.

On 27 September 2019, Bart Schuurman, Assistant Professor at the Institute of Security and Global Affairs spoke to Dutch regional newspaper 'de Gelderlander' about the decline in attention for jihadism.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

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In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

How can you ensure that more experimental drugs reach the finish line? At the moment, only one in twenty cancer drugs that are tested on humans makes it to the market. This is an enormous loss for patients and society. With a grant from the National Growth Fund, Oncode-PACT aims to efficiently select…

Bart Barendregt receives a Vici grant of 1.5 million euros from the NWO for his research project 'One between the Zeros, an Anthropology of Artificial Intelligence in Islam'.

Accelerating the development of new cancer medicines by joining forces—that’s the mission of Oncode Accelerator, a Dutch consortium that recently welcomed three Leiden-based PhD candidates. Under the guidance of Gerard van Westen, Marc Boef, Remco van den Broek, and Lucina-May Nollen are exploring how…

Researchers at eLaw contribute to groundbreaking volume on AI in radiology, offering legal and ethical frameworks, governance models, and solutions for responsible clinical integration.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

The Data-Driven Drug Discovery Network (D4N) is an initiative by researchers from Leiden University and collaborators to join efforts in applying and developing novel techniques from data science to drug discovery and related topics from bioinformatics.