Analysis of drug adversity

We are currently gathering information about how safe Leiden’s residents feel. To do this, we are using online surveys that give us an idea of perceptions of safety in Leiden.

Contact information & address

The goal of pre-clinical development is to bridge the transition from lead compounds to clinical candidates by comprehensively characterizing safety, efficacy, and pharmacological properties. Once a lead compound demonstrates promising activity in disease models, it enters pre-clinical development where…

Is polder rice a feasible circular alternative to cows on peat soil? In May, an experimental trial began, with researchers from Leiden University and Wageningen University & Research (WUR) planting around 3,000 rice plants at the Polderlab near Leiden. The researchers aimed to test rice as a middle…

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Throughout this research project, you will often find us on the streets of Leiden talking to residents about their perceptions of safety. Over the coming months, you may well find our interns Jelle and Roellinde in Leiden’s many districts and in markets, shopping centres and meeting places across the…

High throughput microscopy

Mechanisms fro drug resistance

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

Discovery of metastasis promoting candidate drug targets

How should we protect ourselves from water-borne catastrophe? By “ecologizing safety

Risk has become one of the defining features of modern society. This course examines various types of safety and security risks, and how these are perceived and dealt with in a wide array of professional and academic fields, ranging from criminology, counter-terrorism and cyber security, to philosophy,…

This book investigates the effects of brain lesions in the left hemisphere, specifically Broca's area, on the production and perception of vowels, of word tones and of the linguistic use of sentence melody.

The Liverpool care pathway for the dying patient (LCP) is a multidisciplinary tool developed for the dying phase for use in palliative care settings. The literature reports divergent experiences with its application in a nursing home setting related to its implementation and staff competencies. The…

In this research note, Van der Does & Kantorowicz aruge that citizens that tend to experience political exclusion are often more supportive of direct and participatory forms of decision-making.

What physics controls the properties of quantum matter, such as how electrons flow inside high-temperature superconductors? This question has captivated the physics community and industry for decades, in part due to the great technological potential such materials have, but also because they have resisted…

Experience, Narrative, and Criticism in Ancient Greece pursues a new approach to ancient Greek narrative beyond the taxonomies of structuralist narratologies.

This dissertation aims to provide a critical view of Vietnamese secondary school stakeholders’ awareness of democratic education regarding the core educational democratic values and democratic acts within either the ‘physical’ or digital learning environment.

Comparing terrorist attacks with falling off a step ladder is absurd, writes Jeanine de Roy van Zuijdewijn in NRC Handelsblad on 27 September 2017.

Join this lecture from professor Daniel Aldrich at the Spanish Steps in Wijnhaven on Wednesday 3 November. Dr. Sanneke Kuipers, associate professor in Crisis Governance, will be the moderator of the lecture and she and professor Aldrich give us a preview of the event.

The research presented in this thesis concerns one of the most important questions in software engineering of our time: how can we make sure that software is free from memory safety bugs?

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

A research into how people eat and drink during their daily routines, and the circumstances under which these activities take place.

Prof. Robbert Dijkgraaf used experiments and models from Leiden University for his tv lecture on symmetry. The lecture was broadcast live on channel 1. He showed that our DNA only twists in one direction using a plastic DNA model and he used a Chladni plate to show the symmetry of sound.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

Cell adhesion signaling

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Specially for an experiment conducted by Leiden University, public administration experts and water authority officials came together in a laboratory.

This project investigates how robot testing facilities could help to optimize the regulation for robot technologies.

As a student in Security Studies you are a socially engaged critical thinker eager to study real-life security cases in an academic setting. You focus not just on the broad context of these issues but also on the role of government, institutions and media. Want to know more? Sign up for one of our Open…

LUMC Curium and the Dutch National Youth Council (NJR) have been working on integrating young people’s lived experiences of mental health problems in medical research and training. The aim is to broaden doctors' and researchers’ perspectives and improve the care offered.

Particle lab CERN gives the green light for the test phase of an experiment that aims to produce dark matter particles. Physicist Alexey Boyarsky is one of the initiators.

On Friday 9 March the The Hague Orientation Day took place for the first time at Wijnhaven.

The Honours Academy has recently started working with the new visual technology Virtual Reality (VR). 'It is important to look beyond your own borders and to keep on experimenting. It may not work out, but at least you tried.'

Students from the Advanced Master in Law and Digital Technologies completed a successful work experience programme at Privacy Company in The Hague.

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.