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This dissertation presents the synthesis and evaluation of antibody recognition for various capsular polysaccharide (CP) fragments of Staphylococcus aureus (S. aureus).

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.

On 25 November 2020, Sara Arendse defended her thesis 'De uiterlijke verschijningsvorm in het strafrecht'. The doctoral research was supervised by prof. C.P.M. Cleiren and prof. J.M. ten Voorde.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

We see computer programming as an essential skill. It enables you to be self-sufficient in building tools, processing data, visualizing research output, communicating research results, etc. Moreover, it empowers you to make beautiful things.

Supporting faculties of Leiden University in optimising their education.

The global population speaks approximately 7,000 different languages and approximately half of the world’s population is bilingual. The unique orthographic characteristics of different languages can help us to gain insight into the seemingly simple process of transforming written to spoken words (i.e.,…

In the Catalysis and Surface Chemistry group, we investigate how catalysis works on the molecular level. The group is divided in six subgroups, focusing on different aspects of heterogeneous catalysis, homogeneous catalysis and electrocatalysis.

Nadine Akkerman's book Invisible Agents is the very first study to analyse the role of early modern women spies. The book foregrounds the agency of early-modern women, offering a corrective to the gender bias implicit in modern historiography.

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

In the fall of 2021, Cleveringa professor Roméo Dallaire and world experts shared their thoughts about PTSD, children’s rights, war crimes, humanitarian law, and peacekeeping in a series of conversations about leadership and moral dilemma during times of conflict and crisis.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Bachelor and Master students of all chemistry related studies are more than welcome to take part in our research activities. We have projects on design and synthesis of biologically relevant compounds within an ongoing research project. Supervision, following the apprentice/teacher model, is one of…

On 28 February 2019, Kabir Duggal defended his thesis 'Principles of Evidence in Investor-State Arbitration, Burden, Standards, Presumptions & Inferences'. The doctoral research was supervised by Prof. dr. E. De Brabandere.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

How are the narrative concerns of Nigerian female writers constructed in relation to the structure to their society?

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Get on your bike… or your tandem, unicycle, electric bike, tricycle, penny-farthing, rickshaw or road bike! We’re going on a bike trip!

Everyone is welcome at the Leiden Science Family Day. We have set up a programme with a variety of activities for children, teenagers and adults.

PAIR stands for ethical publishing and transparency. Below you can read about our commitment to COPE principles, copyright compliance and rigorous peer review ensures the integrity of every article we publish.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

To argue that people can control the relative contributions of goal-driven and stimulus-driven processes to decision-making and action selection.

The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

How do technologies of computer vision, which promise to replace humans in the understanding of images, work in practice in the field of security, and what are their ethical and political implications?

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Bachelor, Master, Short Course, PhD

The two-year Advanced Computing and Systems programme (120 EC) includes mandatory core courses and electives, as well as a Master's Thesis Research Project.

Chinese Linguistics at Leiden University offers you an excellent opportunity to benefit from our long-standing expertise in Chinese linguistics

What evaluative languages (errors, mistakes, vices, etc.) did book reviewers employ? To what extent and on what occasions did they invoke early modern vices? And to what extent did this differ across fields or change over the course of the century?

The Faculty of Social and Behavioural Sciences is committed to being a safe, comfortable, and equitable space for both staff and students: a place where a diversity of people feel valued and welcome, where there is room for a diversity of perspectives.

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…

Immerse yourself: read books, listen to podcasts and watch films about racism, discrimination and the colonial past.

The European Homicide Monitor (EHM) offers a standardized framework for countries and regions to compare homicide characteristics, patterns and trends.

Research at the BIOSYN group is comprised of the following research themes:

French Language and Linguistics at Leiden University offers a wide array of courses covering theoretical and applied linguistics, including language acquisition, syntax, and semantics.

On 12 January 2022, Mirjam Franke defended the thesis 'Over de grens van de onrechtmatige daad'. The doctoral research was supervised by Prof. A.G. Castermans and Prof. J.H. Crijns.

The research group Corporate Governance and Strategy investigates how, with whom and for whom a firm/corporation creates/captures value, in order to inform practice and rule makers about governance issues. By focusing on the dual character of the firm as an entity by itself but also consisting of stakeholders,…

Read more about the International Network Open Science & Scholarship Communities in our Vision and Mission statements.

Under Dutch law, like German or English law, the violation of a statutory provision does not establish civil liability for damage caused to another person. Such liability requires that the statutory provision concerned aims to protect against the damage or, put differently, that the harmed interest…

An important aspect of the promotion and safeguarding of good practices at the Institute of Psychology is to make sure that employees are being facilitated and guided by offering information about and resources for training. On this page, an overview of various mandatory and recommended training is…

A study by a Leiden-Wageningen group shows that present-day humans are biologically poorly equipped to deal with the toxins they are regularly exposed to in smoky environments: compared to earlier hominins, we modern humans are probably even worse off. The study appeared in Molecular Biology and Evolution.…