The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.

Promotor: Prof.dr. T. Schmidt

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

In this article, Sanneke Kuipers and Machiel van der Heijden examine how patterns of policy inaction emerge in public organisations, arguing that systematic biases and organisational decision premises contribute to the failure of policymakers to address pressing societal issues.

In this working paper, Dr. Joris Larik provides an analysis of the governance and dispute settlement mechanisms under the Ireland/Northern Ireland Protocol.

On December 10, Kazakh pianist and composer Rakhat-Bi Abdyssagin will perform at the Stadsgehoorzaal in Leiden. A remarkable event where music and modern physics come together.

Newspaper NRC and popular scientific magazine New Scientist write about Corentin Coulais’ research on one-way-traffic metamaterials. He published a paper on this subject in Nature on February 13.

An important discovery makes it possible to communicate complex information among multiple people without the message being cracked. The communication can also relate to complex information.

To be able to measure small forces or small deviations from Boltzmann, the external vibrations at the resonance frequency must be very low. To achieve this, we have developed a very soft vibration isolation system and combine it with several other measures to reduce vibrations in our dilution refrigerators.…

Physics and Engineering Approaches to Biomedicine and Pharmacology

Vibrating carbon monoxide molecules adsorbed at the surface of a salt crystal stop moving after a few milliseconds. Scientists now discovered this is dominantly due to the emission of electromagnetic waves. The role of the chemical bond at the surface thereby appears to be less important than previously…

A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals (including therapeutic proteins, vaccines and advanced…

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

What is the state of access to justice in real property grievances in today’s Libya, and how should it be improved?

On the 4th of November, Aliza successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Aliza on this achievement!

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

The research group of Semonti Bhattacharyya at the Leiden Institute of Physics studies quantum transport measurements in Van der Waals heterostructures.

How interdisciplinary teaching supports the development of students’ competencies

How can international investment law and arbitration take account of the public interest in, and more broadly, the public dimension of, the relations between foreign investors and host States ?

Industrial Ecology

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Nature, nurture and neural mechanisms of social emotion regulation in childhood

Can a newly developed, app-based, personalized maintenance program enhance the effectiveness of the exposure-based one-session-treatment for children with a specific phobia?

Multicopper oxidase, laccase, can efficiently reduce oxygen to water and are mostly used in the enzymatic biofuel cells.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

How can the problems in establishing a sustainable common security and defence mechanism for the EU be explained?

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

On 3 June 2021, Vassilis Dafnomilis defended his thesis 'Taxation of Cross-border Inheritances and Donations'. The doctoral research was supervised by Prof. F. Sonneveldt and Prof. S. Douma (UvA).

How does the development of digital technologies impact society, and law/regulation within that society?

Promotor: E. Bouwman, Co-promotor: S. Bonnet

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

What are the social and neural mechanisms that contribute to fluctuations in self-esteem in healthy adolescents and adolescents with depression?

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Delineating psychophysiological endophenotypes of social anxiety disorder

This thesis describes the use of the evolutionary approach in the study of language change, aiming to provide a better insight in the mechanisms that play a role in language change and to validate this approach in the field of language change.

Synthetic or artificial cells are vesicles, often lipid vesicles, with wide ranging applications from drug delivery to nanoreactors in biocatalysis. We are developing polymer-lipid hybrid vesicles for applications in compartmentalised biocatalysis, in which the polymer has been shown to greatly enhance…

On 14 December, Jouke Tegelaar defended the thesis 'Single supervision, single judicial protection? Towards effective judicial protection in Single Supervisory Mechanism composite procedures'. The doctoral research was supervised by Matthias Haentjens and Willemien den Ouden.

How do we process language and speech? How do we integrate information at different levels – intonation, sentence structure, meaning, tone, words, sounds - and how does information at one level interact with information at another level?