This research note argues that the “lone wolf” typology should be fundamentally reconsidered.

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.

The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’

Supervisor: Lizi Xia

The CIGR comprises research groups from the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

With a headwind of 80 kilometres per hour, pouring rain and freezing temperatures, Jurjun van der Velde cycles down the Oosterscheldekering. On his traditional Dutch bike with back pedal brake, he is the second PhD student from the faculty to win the title.

PhD defence

Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

High throughput microscopy

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

This dissertation aims to advance understanding of amoeboid single cell migration under the influence of changing physicochemical environmental properties. The particular focus is on the relatively unknown influence of differing physical properties in the extracellular environment, such as the migratory…

We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments. We apply our technology and methods to find biomarkers for key disease pathways and toxicity in clinical studies and in…

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Medicine with Kilimanjaro Christian Medical Center in Tanzania.

PhD defence

PhD defence

PhD defence

Polarisation in our society is on the rise. What makes people increasingly radical? How do we protect ourselves from extremist, terrorist or criminal threats, be they physical or in the cyber world? And what role do intelligence services play in this?

This project sets out to map, document and analyze instances of squatting in Leiden from 1970 to 1990, in order to set up an online Digital Archive of Squatting in Leiden. This archive will function as an online resource for academic research, as well as a starting point for public activities such as…

In 2022, many of our staff and students won fantastic prizes and were awarded important research grants.

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

Two excellent young chemists, Jeroen Codée and Sander van Kasteren, have received an ECHO grant for €260,000 from the Netherlands Organisation for Scientific Research (NWO). This funding will allow them to begin their research projects.

The Leiden Centre for Continental Philosophy (LCCP) is a research community based at the Institute for Philosophy at Leiden University. LCCP is envisaged as an open space for stimulating discussion, critical debate and inventive co-operation in the local and international philosophical community. We…

What was the environmental impact of the industrial mining revolution that transformed southern Africa? Specifically, what was the impact of industrial mining when viewed from a more than human multi-species perspective?

Conference

Improving healthcare with our scientific discoveries: that is the goal of pharmaceutical research at Leiden University. And there’s a lot involved in that. Our research starts with the discovery of the effect achieved by a particular substance, and sometimes continues all the way through to the development…

Living systems scale from unicellular microbes to complex multispecies communities that constantly change over time. Within the theme Development & Disease, we enhance our fundamental understanding of development and homeostasis of living cells and systems. We analyze the normal situation and how stresses…

This timely and engaging book examines the rise of populism across the globe. Combining insights from linguistics, argumentation theory, rhetoric, legal theory and political theory it offers a fully integrated characterization of the form and content of populist discourse.

Unmanned aerial vehicles (UAVs), often referred to as drones, have become easy and inexpensive to buy, and it is generally expected that the use of drones by private individuals, businesses and public authorities will increase tremendously in the coming years. This raises questions as to what is technologically…

Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).

Global Challenges is the research programme of the Leiden Institute of Cultural Anthropology and Development Sociology.

Fundamental research in the ALgebra, Geometry And Number Theory

EuDEco (Modelling the European Data Economy) is a Coordination & Support Action (CSA) receiving funding from the European Union’s Horizon 2020 programme.

The authors in this volume explore how external innovations (products, technologies, services, institutions and processes) have been appropriated in African societies in order to be acceptable and relevant to local conditions, expectations and demands.

Pottery traditions and social interaction in the earliest Neolithic of the Lower Rhine Area

This paper contributes on an increasing body of work on radicalisation. It specifically focuses on what distinguishes individuals whose behavioural radicalisation includes involvement in terrorist violence from those whose behavioural radicalisation does not.

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

Sweetie 2.0 is a research project commissioned by Terre des Hommes on online child sex tourism and criminal law.

The Turn of the Soul: Representations of Religious Conversion in Early Modern Art and Literature