770 search results for “that immune responses” in the Public website
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Two NWO ECHO grants for Leiden Chemistry
Two excellent young chemists, Jeroen Codée and Sander van Kasteren, have received an ECHO grant for €260,000 from the Netherlands Organisation for Scientific Research (NWO). This funding will allow them to begin their research projects.
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Blog Post | Diplomacy’s Response to the Coronavirus (Part II)
The previous blog post in this series discussed the role of international diplomacy during the coronavirus crisis. This post focuses on diplomacy and its challenges in post-corona times. Specifically, the blog post argues that diplomats will face a range of challenges following the Covid-19 pandemic…
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Immunity to the respiratory syncytial virus: dynamics of the antibody response
PhD defence
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Variation in the immune system and vaccine responses in Low to Middle Income Countries
PhD defence
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Placebo research: Pharmacological conditioning
The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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Lab facilities Health, Medical and Neuropsychology
Psycho-physiological studies for health and disease.
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Inverse electron demand Diels-Alder pyridazine elimination: synthetic tools for chemical immunology
The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…
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Synthesis and applications of cell wall glycopolimer fragments from Staphilococci and Enterococci
Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…
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Telders Case
2026
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Lemay Lab - Iontronics
Research in the Lemay Lab concentrates on Iontronics: the physics of mixed electronic-ionic charge transport.
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Mohit KhubchandaniFaculteit der Rechtsgeleerdheid
m.khubchandani@law.leidenuniv.nl | 33 765644484
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Serkan Aslans.aslan@lacdr.leidenuniv.nl | 071 5275919
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Testing of a malaria vaccine gets the green light
Researchers at Leiden University Medical Center (LUMC) and Radboud university medical center have been given the green light to deliberately infect volunteers with malaria in order to test a highly promising vaccine on them.
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Immune cell networks in Inflammatory Bowel Disease
PhD defence
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Immune and Metabolic Dysregulation in Liver Cancer
PhD defence
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Walking the tightrope of immune modulation
PhD defence
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Blog Post | Diplomacy’s Response to the Coronavirus
The coronavirus outbreak has demonstrated the strengths and weaknesses of modern diplomacy. In this two-part series of blog posts, I will attempt to analyze how diplomats grappled with the coronavirus pandemic and how international diplomacy can best prepare to meet similar challenges in the future.…
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Timo KosExecutive Board
t.kos@cvb.leidenuniv.nl | 071 5273127
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Single-cell Dissection of Immune System Aging and Acute Myeloid Leukemia
PhD defence
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Physics and Engineering Approaches to Biomedicine and Pharmacology
Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.
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The scientists behind LED3
Meet the scientists within the LED3 community
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Fighting corona starts with sharing data responsibly
Gathering and distributing patient data can make an important contribution to containing the coronavirus. But if we want to be successful, we need better data. With this objective in mind, Leiden data stewards have joined the Virus Outbreak Data Network (VODAN).
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Parents responsible for obesity in children?
‘The idea that overweight and obesity are the fault of parents and/or the child, is rubbish.' Roxanna Camfferman, who specialises in child and adolescent studies, explains her proposition. Her PhD dissertation is on the role of upbringing in child obesity.
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Meuwese on new developments in Dutch cabinet’s response to child benefits scandal
In recent days and weeks, experts have been falling over themselves to point the finger at the main culprit in the Dutch child benefits scandal. Although this debate is fascinating, equally important are the broader lessons to be drawn from the scandal in relation to constitutional and administrative…
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Erik Danene.danen@lacdr.leidenuniv.nl | 071 5274486
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Research
The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Cell Systems and Drug Safety, Medicinal Chemistry and Systems Pharmacology and Pharmacy, and the Metabolomics and Analytics Centre.
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Repair a bad kidney or make a new one to order
Searching for ways to delay the need for a transplant and trying to build kidneys to order.
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Feeding on the fat: how mycobacterial infections disrupt lipid metabolism
How do pathogenic mycobacteria alter lipid metabolism in human cells and patients, and which disrupted pathways could be targeted for new antibiotics?
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Topic: Stress and stress-related disorders
The precise psychobiological mechanisms leading to chronic physiological stress responses have not been sufficiently explained, although stress is a major risk factor for disease and early death. A problem for conventional stress theory is that most of these responses seem to occur in situations without…
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LUSBHR Conference Corporate Responsibility: Current Issues in the Field of Fundamental Rights & Sustainability
On Friday afternoon, 15 November 2024, the conference Corporate Responsibility: Current Issues in the Field of Fundamental Rights & Sustainability will take place.
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The EU’s Response to Russia’s Invasion of Ukraine: International and European Perspectives
Since Russia’s invasion of Ukraine in February 2022, the European Union (EU) and its Member States have adopted wide-ranging legal and political measures to support Ukraine in its struggle.
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exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia
Exploring metabolomics-based biomarkers for diagnosis and treatment response monitoring of community-acquired pneumonia
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und Literatur // Taking Positions on the ‘Refugee Crisis’: Critical Responses in Art and Literature
The recent rise in global migration movements and the simultaneous attempts to prevent migrations to the Global North in general and Europe in particular have produced numerous images and narratives that try to record and convey these events and their actors.
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Party Preferences? What Accounts for the Variety of National Policy Responses to the COVID-19 Pandemic in Europe?
What Accounts for the Variety of National Policy Responses to the COVID-19 Pandemic in Europe?
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Decoding the Immune and Structural Landscapes of the Prenatal and Emphysematous Lung at the Single-Cell Level
PhD defence
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Bob van de Waterwater_b@lacdr.leidenuniv.nl | 071 5276223
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Development of Comprehensive and High-throughput metabolomics techniques
A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…
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Research stories
Would you like to know more about our research using laboratory animals or our studies on alternatives to animal testing? If so, take a look at the news articles on the right-hand side of the page (for mobile users, see the bottom of the page).
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Human epidermal lipid biosynthesis in health and disease
How are the epidermal lipid pathways involved in health and disease.
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Advanced in vitro models for studying drug induced toxicity
Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price
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Unraveling multifaceted roles of Grainyhead-like transcription factor-2 in breast cancer
Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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Microstructural and Metabolic Alterations in the Zebrafish Brain Induced by Toll-Like Receptor 2 Deficiency
Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.
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Targeting lipid metabolism to develop host-directed therapeutics for mycobacterial infections
Our research aims to develop drugs that boost the host immune response to better defend us against mycobacteria.
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Civil Liability for Damage caused by Global Navigation Satellite System
On 17 December 2018, Dejian Kong defended his thesis 'Civil Liability for Damage caused by Global Navigation Satellite System'. The doctoral research was supervised by Prof. dr. P.M.J. Mendes de Leon.
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Key publications
Key publications of the Skin Barrier and Vaccination group.