Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Thomas Hansen is the recipient of the 2020 KNCV-Backer Prize for best organic chemistry thesis in the Netherlands.

An interdisciplinary team of Leiden researchers has discovered that wasting syndrome, a severe byproduct of tuberculosis, is the same for all humans and animals studied. The discovery offers new opportunities to investigate the still insufficiently understood condition. The scientists also developed…

Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).

Thesis focused on uncovering the underlying mechanisms of the lysosomal storage disorders Gaucher's disease using chemical tools, biochemical assays and lipidomics.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

On January 11, 2025, our esteemed colleague and emeritus professor Arne van der Gen passed away. Arne was a professor of Organic Chemistry from 1980 until his retirement in 2000, and was a great advocate of the integration and harmonization of European education in chemistry. Arne was 90 years old.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

As part of the events to mark the 100th anniversary of the International Labour Organization, the Department of Labour Law of Leiden University has organized a film evening together with Kijkhuis cinema in Leiden.

In a promotional video for the SUNRISE initiative, prof. Huub de Groot explains the impact and ideas behind artificial photosynthesis.

On Friday 10 July the Towards Biosolar Cells research programme was granted a budget of 25 million euros by the Dutch Government. The Ministry of Agriculture, Nature and Food Quality recommended the programme because it will contribute to green energy, improve food supplies and a create a more sustainable…

This thesis describes research aimed at discovering inhibitors selective for either of the two endoplasmic reticulum α-glucosidases, ER-I and ER-II, with the overarching goal of discovering new antiviral agents to treat viruses that rely on host N-glycosylation for proliferation.

The Organ Art of the first female German concert organist and Bremen Cathedral organist and

Researchers at Leiden University have been awarded a €4 million EU grant to develop climate-neutral fuels. With this money they will expand the broad research community that focuses on green energy. If we work together, we can make the rapid progress that is needed, says Prof. Huub de Groot, Professor…

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

Anthe Janssen graduated ‘summa cum laude’ for the master’s programme Chemistry.He used NMR methods to gain insight in the syntheses and behavior of bio sugars. With this knowledge future therapeutics and research tools in hemical and medicinal biology can be developed. Anthe was awarded € 2.500.

The fastest chemical reaction in the universe takes place inside our eyes.

This year, the International Institute of Air and Space Law (IIASL) attended the first days of the 41st Assembly of the International Civil Aviation Organization (ICAO).

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

On Tuesday 11 February, the European Data Protection Supervisor, Mr. Wojciech Wiewiórowski, visited eLaw, - center for Law and Digital Technologies at Leiden Law School to give a lecture on facial recognition systems and data protection in Europe.

The postdoc received the 2020 Thesis Prize for her PhD research on the role of the EU Member States in regulating and remedying corporate human rights violations.

On 18 February 2023, our esteemed former colleague Robert Louw passed away. Rob was 86 years old.

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

Traditional biochemical methods for studying organelles require cell disruption, preventing the real-time observation of dynamic intracellular processes.

The work described in this Thesis is focused on the assembly of oligosaccharide fragments derived from a fungal polysaccharide, galactosaminogalactan (GAG) and fragments of the exopolysaccharide Pel, generated by Pseudomonas aeruginosa.

Education & outreach

Huub de Groot is one of the 55 authors for the book The Colours of Energy. The book consists of Essays on the Future of Energy in Society in which leading energy thinkers explore the future of energy in society.

On October 26, the Dutch Embassy in Berlin celebrated the opening of a new research network for Dutch academics in Germany. Dutch minister of Education, Culture and Science Robbert Dijkgraaf gave the starting signal for this new initiative.

For his significant original contributions in the field of carbohydrate research, chemist Jeroen Codee will be awarded the biennial Carbohydrate Research Award for Creativity in Carbohydrate Chemistry.

Friso Selten recently started a PhD position that is part of the SAILS program. This PhD project is a collaboration between FGGA, LIACS, and eLaw, and is supervised by Bram Klievink (FGGA), Joost Broekens (LIACS), and Francien Deschene (eLaw). In the project Friso will investigate the influence of artificial…

Professor André Baranski is a champion for improving organ procurement. He believes there should be standardised training and certification for procurement surgeons. This is what he said in his inaugural lecture on 16 April.

Promotor: Prof.dr. G.P. van Wezel

Since 1919 the International Labour Organization (ILO) has been promoting the rights of workers worldwide. On 7 February, Leiden University hosted the symposium celebrating the 100-year anniversary of the foundation of the ILO. Leiden emeritus professor of International Labour Law Paul van der Heijden…

Leiden researchers have found minute movements in the laccase enzyme. This discovery could lead to the development of much more efficient biofuel cells. Publication in Biophysical Journal.

At Leiden Observatory, researchers investigate the origin of stars and their planetary systems. They detect and characterize planets around other stars, which are called exo-planets. They study how stars and planets form. And they follow molecules from interstellar clouds to nascent planet systems.…

In this work, we illustrate unconventional approaches towards the fabrication of edge functionalized graphene nanostructures and bidimensional architectures in polymeric and metallic supports, with an outlook towards molecular sensing devices.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

The High-Tech Innovation specialisation consists of a 60 EC track alongside the students' core MSc programme: Astronomy, Chemistry, Computer Science, Mathematics and Physics.

At Molecular Physiology we teach the following courses within the Leiden Institute of Chemistry's Chemistry and Life Science and Technology programmes.

Professor Bert Meijer has been reappointed as a member of Leiden University’s Board of Governors by the Minister of Education, Culture and Science, Ingrid van Engelshoven.