Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

Control of infectious diseases poses continuous challenges for human health.

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Doctoral Thesis

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Research in the Lars Jeuken group focusses on redox-active proteins and membranes enzymes, aiming to understand bacterial respiration at the molecular level for the development of antimicrobials and semi-artificial photo-synthetic cells.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Are you graduating at the Faculty of Science? Or are you supervising a PhD student? At the Graduate School of Science you find support at every phase of your PhD.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Promotor: J.A. van Veen, Co-promotor: E.E. Kuramae

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Exploiting the Ecological Role of Natural Products as Novel Biocontrol Agents (LIPQUORUM): The central aim of LIPQUORUM is to unravel the intricate interkingdom signaling mechanisms between the Bacillus subtilis species complex and the devastating fungal pathogen Sporisorium scitamineum.

Promotor: Prof.dr. G.P. van Wezel

The Supramolecular & Biomaterials Chemistry group comprises the PIs Alexander Kros, Roxanne Kieltyka and Gregory Schneider, and is active in the field of self-assembly of amphiphilic peptides and applying them in supramolecular chemistry.

Parents may pass anxiety onto their offspring by exposing them to anxious behaviors in novel situations. Just as the parents’ anxious signals lead to anxiety, parents’ confident signals can ward off anxiety in the offspring. This project is seeking a new way to break anxiety transmission in the family…

Shyness is perfectly normal, Michiel Westenberg stated in his farewell lecture. But that doesn’t mean that social anxiety shouldn’t be identified and addressed in good time. ‘Serious shyness has strong genetic roots; you don’t just get over it.’

This article explores how to think about solidarity, considering the diverse stories, spaces, practices, bodies, and temporalities that shape a city.

Negative perceptions of ambiguous social cues, social performance and physical arousal in socially anxious youth

The interdisciplinary programme Social Resilience & Security is inviting proposals for seed funding. The programme aims to combine knowledge and expertise from five different faculties to study transgressive behaviours, its dimensions, aetiology, and effects of interventions with a multidisciplinary…

EU migrants receive less frequent and lower benefits and allowances than Dutch citizens. This is according to research by Leiden economists Olaf van Vliet and Eduard Suari Andreu published as part of the Social Citizenship & Migration research programme. The research is discussed in Dutch newspaper…

The call for a social media ban for children is louder than ever. Professor of Children's Rights Ton Liefaard argues in ‘Trouw’ newspaper that this would be unwise. 'For children, online and offline aren't different worlds'.

Here I propose to study the relationship between autonomic pupil-synchronisation and trust, at the behavioural and neural level, and examine a targeted set of possible contextual moderators.

Samir Negash, PhD candidate at Leiden University and Olaf van Vliet, Professor by special appointment Comparative Welfare State Analysis at Leiden University wrote a paper regarding the topic of immigration and the conditionality of unemployment benefits in OECD countries.

This project investigates which aspects of social media content adolescents attend to and how these relate to their credibility judgments, aiming to systematically understand their susceptibility to misinformation and inform effective educational programs that foster youth’s resilience to misinforma…

On the first day at a new job, you have sweaty palms, nerves race through your system, and you feel insecure. Now, a couple of months later these feelings have left. You know what to do in your new role and have become part of the organization. The process leading to this result is called organizational…

The Australian parliament passed a law banning social media for youth under sixteen in late November. This solves nothing, argues Simone van der Hof, Professor of Law and Digital Technologies, in NRC. ‘Services should be held to the law.’

As schools in the U.S., students have to enter through security gates; schools in Belgium were forced to remain closed for several days after the attacks there; and even in the Netherlands various bomb scares have led to children having to stay at home. And yet fear of terrorism remains a difficult…

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

UnMiSSeD studies the interaction between misinformation and science in societal debates using a mixed qualitative-quantitative approach.

OSCL members, amongst which our representative in the Archaeology faculty, were part of Data Carpentry for Social Sciences. Here's what happened.