This dissertation is concerned with the development of grammar. Starting from a usage-based perspective, which holds that children use domain-general learning mechanisms to acquire the grammatical patterns of their mother tongue, Beekhuizen shows how to operationalize various concepts from this tradition…

We describe certain birational modifications of nodal relative curves over a regular base of arbitrary dimension.

Promotor: Prof.dr. M. Danhof, Co-Promotor: J. de Jongh

Behrouz Karoubi defended his thesis on 15 June 2016

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

To what end and how does Plautus constantly underline the Helleni(sti)c provenance of his art? How does this aspect relate the author’s originality?

Barrier function is the natural role of the skin. The lipid matrix present in the outermost layer of the skin, the stratum corneum is important for this function.

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

Promotores: Prof.dr. G.R. de Snoo & Dr. R. Heijungs

In design optimization problems, engineers typically handcraft design representations based on personal expertise, which leaves a fingerprint of the user experience in the optimization data. Thus, learning this notion of experience as transferrable design features has potential to improve the performance…

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

In this research project Nizar Rohana analyzes and reflects on taqsīm recordings by two leading figures of ‘ūd playing who were pillars of modern Arabic music, namely the Egyptians Muḥammad al-Qaṣabjī (1898-1964) and Riyāḍ al-Sunbāṭī (1906-1981).

Uncertainty and noise are frequently-encountered obstacles in real-world applications of numerical optimization. The practice of optimization that deals with uncertainties and noise is commonly referred to as robust optimization.

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

Several techniques are explored for going beyond the born-oppenheimer static surface model for molecule-surface reactions.

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

How can the transport of molecules in living cells help to target medicines at exactly the right place?

Promotores: H. Schiessel, G.T. Barkema

Promotor: Prof.dr. M.K. Richardson

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

The project Deconstructing Stability aims to improve reconstructions of late prehistoric landscapes and predictive models for the purpose of archaeological heritage management.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

What are the capabilities or limitations of traveling between islands and how does this reflect seasonal variation? Is it possible to show higher levels of connectivity between islands based on generated pathways between several sites on two separate islands?

He’s a fast and animated speaker, which is only logical because Gerard van Westen is driving an express train. His destination? A virtual human, consisting of algorithms that predict what an administered substance will do in the body. The train is already a long way down the line and the pharmaceutical…

This thesis focuses on important life history traits and their trade-offs using two hexapod models. Particularly, the trade-off between immune defense and embryonic developmental speed is a central theme of this study.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

This thesis describes the use of the evolutionary approach in the study of language change, aiming to provide a better insight in the mechanisms that play a role in language change and to validate this approach in the field of language change.

Assessing the feasibility and legitimacy of the current model of global tax governance and the role of the OECD and EU in international tax law-making.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

Chapter 1,contains the numerical verification of the Birch and Swinnerton-Dyer conjecture for hundreds of Jacobians of hyperelliptic curves of genus 2, 3, 4 and 5.

Cardiovascular diseases are still a major concern for the global health.

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

Promotor: J. A. Bouwstra

M. Danhof, Co-promotor: O.E. Della Pasqua

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.