3,371 search results for “modelling ” in the Public website
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
PhD defence
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epidemiologic methods on findings in studies of causal effects and prediction modelling
PhD defence
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Fluorescent in vivo models for hematopoietic stem cell and lymphoid lineage analysis
PhD defence
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Modelling the Interactions of Advanced Micro- and Nanoparticles with Novel Entities
PhD defence
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Learning-based Representations of High-dimensional CAE Models for Automotive Design Optimization
PhD defence
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In vitro models of bone-forming tumours: from target to treatment
PhD defence
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Experimental pain models for the evaluation of next-generation analgesics in clinical pharmacology studies
PhD defence
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Towards circular and energy-efficient management of building stock
Material circularity and energy efficiency are highly relevant and intertwined issues for the transition towards a carbon-neutral and circular built environment. In the Netherlands, the building sector has been rendered a priority towards a circular and low-carbon society.
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LED3 Lecture: Organoids to model human health and disease in vitro
Lecture
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Three Leiden scientists receive NWO ENW-KLEIN grant for innovative research
The origins of Surinamese rice, a digital twin of the Earth and a large big-data project in the Chilean sky: three Leiden scientists receive an ENW-KLEIN grant for innovative, fundamental research.
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Leiden hosts seventh Survival Analysis for Junior Researchers conference
Next April, Leiden will host the seventh annual international Survival Analysis for Junior Researchers conference (SAfJR2018). This three-day event is aimed at career-young statisticians with an interest in the application and development of time-to-event analysis and related topics. The conference…
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Karsten Lambers appointed as Professor of Digital and Computational Archaeology
In January, Dr Karsten Lambers was appointed as Professor of Digital and Computational Archaeology at Leiden University's Faculty of Archaeology. With his extensive background in both archaeological research and computational sciences, the installation of Professor Lambers further strengthens this discipline…
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How to determine medication dosages for premature babies
Premature babies almost always require treatment with medication. Doctors usually determine the dosages based on data from children who were not born prematurely, while preterm infants often develop differently. Medication researcher Aline Engbers investigated three commonly used drugs, focusing on…
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Skin Lipids: Localization of Ceramide and Fatty Acid in the Unit Cell of the Long Periodicity Phase
The lipid matrix of the skin's stratum corneum plays a key role in the barrier function, which protects the body from desiccation. The lipids that make up this matrix consist of ceramides, cholesterol, and free fatty acids, and can form two coexisting crystalline lamellar phases: the long periodicity…
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Generalized Strictly Periodic Scheduling Analysis, Resource Optimization, and Implementation of Adaptive Streaming Applications
This thesis focuses on addressing four research problems in designing embedded streaming systems.
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Language and Information: adventures in understanding large language models in hybrid settings
Lecture
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LCN2 Seminar: Network model selection via the Minimum Description Length principle: the effects of ensemble non-equivalence
Lecture
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Van Marum Colloquium: Thermodynamic modeling of the electrode-electrolyte interface - Double-layer capacitance, Solvation number, Validation
Lecture
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World news: eleven asteroids on a collision course with Earth
The discovery that eleven asteroids might collide with our Earth has become world news. The research of three Leiden astronomers has appeared on more than 190 news sites worldwide, from America to China. They developed and trained an artificial neural network for this discovery.
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Lunchtime Speaker Series: MacBERTh: A Historically Pre-Trained Language Model for English (1450-1950)
Lecture
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Applications of multisource data-based dynamic modeling to cell-cell signaling and infectious disease spreading
PhD defence
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Mechanistic insight and rAAV assays on mouse & human retinal organoid models
PhD defence
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Preclinical and ‘near-patient’ models for the evaluation of experimental therapy in prostate and bladder cancer
PhD defence
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Nano shapes micro : Impacts of metallic nanoparticles on microbial communities
This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.
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Champion in headwind and predictions
It is a stormy Sunday afternoon, with gusts of a whopping 110 kilometres per hour. Chemist Teun Sweere defies the enormous headwind on his city bike and wins the NK Headwind cycling after 22,5 minutes. A new highlight follows six months later: his PhD defence (14 June).
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Noortje Dannenberg
Science
n.dannenberg@biology.leidenuniv.nl | +31 71 527 5075
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Erik Danen
Science
e.danen@lacdr.leidenuniv.nl | +31 71 527 4486
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Tackling messy blood vessels to fight cancer
With a Vici grant of 1.5 million euros, Professor of Mathematical biology Roeland Merks will look for ways to fix messy and leaky blood vessels in tumours. His research combines mathematical simulations and lab experiments in a unique way.
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Liesbeth de Lange wins Lewis B. Sheiner Career Prize
Pharmacologist Liesbeth de Lange has won the Lewis B. Sheiner Lecturer Award from the International Society of Pharmacometrics (ISoP). As Professor of Predictive Pharmacology she is working, among other things, on a mathematical model that can predict drug concentrations in the brain. On the occasion…
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How do children's kidneys eliminate drugs?
What dose of medicine do you give a child? That depends to a large extent on how quickly their kidneys remove the drug from the blood. For ethical reasons it is impossible to measure this directly in little patients. PhD candidate Sinziana Cristea combined different types of modelling and lots of data…
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Can we predict the future of ecosystems throughout the world?
To what extent does human intervention influence the world’s biodiversity? And can we predict how biodiversity and ecosystems will change in the coming years? Inaugural lecture by Peter van Bodegom, Professor of Conservation Biology, on 8 May.
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Rob van Wijk
Science
r.c.van.wijk@lacdr.leidenuniv.nl | +31 71 527 4505
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Hypoxic Signalling and Tuberculosis
IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.
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R-ELEVATION
How do plant defense genes get activated?
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Tomb 45 (Luxor, Egypt): some recent results on geo-referenced 3D modelling
Lecture
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Ensnaring tumours in their own web
Erik Danen is looking at how to inhibit tumours that do not respond well to medicine – and he is making some headway. The Professor of Cancer Drug Target Discovery studies the interaction between tumour cells and their surroundings. Inaugural lecture on Friday 10 May.
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The mysteries of exoplanets and supermassive black holes: two Vici grants for Leiden Observatory
One unravels the origin of the largest black holes in the universe, the other investigates the influence of stellar wind on the atmosphere of exoplanets. Both Elena Maria Rossi and Aline Vidotto receive a Vici grant for their research into the mysteries of the universe. ‘I have no idea yet how we can…
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Mismatched timing: how climate change challenges bird migration
How does climate change affect the migration routes of birds? Mainly negatively, according to a new study from Yali Si from the CML. ‘It changes the timing of natural events differently in each region,’ she explains. ‘This can lead to a growing mismatch between the availability of food and the supposed…
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Producing all our food nationally: is it even possible?
According to a new study, for half of the world population the answer would be yes. For the other half: maybe? Leiden environmental researcher and head author Nicolas Navarre explains: ‘With improvements to crop yields, reductions in food waste, and changes in consumption patterns, 90% of people could…
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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Studying the Benefits of Using UML on Software Maintenance: an Evidence-Based Approach.
Including modelling as part of software development appears to have various benefits.
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A game of Mastermind to unravel Alzheimer’s disease
In order to better understand the course of Alzheimer’s disease, Frédérique Kok believes that a strategic and structured approach is needed: the Mastermind research approach. With her LUF grant, Kok wants to generate high-quality data to build a mathematical model that can recognize the onset of the…
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‘Test medicines after five days’
What is the best method and time to test the effectiveness of medicines? PhD student Rob van Wijk of the Leiden Academic Centre for Drug Research (LACDR) discovered zebrafish larvae are best used in drug research when they are five days old. His findings were published on 15 February in the journal…
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Scientific computing for Drug Discovery in Python and/or R
Data analysis with Python and R are rapidly becoming essential skills for modern scientists. Therefore, we are offering courses to develop your scientific computing skills. Those courses are optional for LACDR PhD candidates.
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Archaeological Prediction and Risk Management
Alternatives to current practice
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Student projects
Are you looking for a research project?
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Computational Biology
Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.
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Programme structure
The master's specialisation Methodology and Statistics in Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.
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Into the Darkness: Forging a Stable Path Through the Gravitational Landscape
In this thesis we study the landscape of gravitational models which modify GR by introducing an additional scalar degree of freedom (d.o.f.) to source Cosmic Acceleration.