We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

With tomography it is possible to reconstruct the interior of an object without destroying.

This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.

In this thesis we present several methods to automate tomographic reconstruction algorithms and several novel tomographic reconstruction algorithms with the focus on being easily applicable and efficient to use.

Promotor: K.J. Batenburg

An experimental approach to organic palaeolithic technology

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

This dissertation presents a comprehensive description of Xinka, an indigenous language from southeastern Guatemala. The description is based on a missionary grammar that is titled Arte de la lengua szinca and was written by the priest Manuel Maldonado de Matos around 1773.

We live in a world of things and people in the past must have been as closely entangled with their material surroundings as we are now. In the Laboratory for Artefact Studies Van Gijn takes a close look at the biographies of objects: what kind of raw material an object is made off and what is its provenience,…

Dorothea Schulz & Martin Hense

Radiography is an important technique to inspect objects, with applications in airports and hospitals. X-ray imaging is also essential in industry, for instance in food safety checks for the presence of foreign objects.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Promotor: Prof.dr. K.J. Batenburg

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

The chaotic years after the Civil War are often seen as a time of uniquely American idealism—a revolutionary attempt to rebuild the nation that paved the way for the civil rights movement of the twentieth century. But Adam Fairclough rejects this prevailing view, challenging prominent historians such…

What if you could watch a CT scan live, instead of analysing the images afterwards? If it is up to the Leiden mathematician Jan-Willem Buurlage, that will soon be a reality. He is developing methods to make the algorithms behind 3D scans faster. Quite a challenge: ‘Just like mathematicians, computers…

Leiden University archaeologists are reconstructing houses from the Stone Age, using only resources available during that period. This method offers surprising insights into the ingenuity of our distant ancestors, and challenges existing archaeological views.

An assessment of Libyan legislation

Joost Batenburg is a mathematician and computer scientist who works to build bridges to other disciplines. He hopes to bring intelligent software to fields where it can make a difference. Conversely, he also seeks connections to the disciplines that are needed to make AI a success.

Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

The imaging group focuses on bio-imaging, image analysis and visualization.

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements

Proceedings of the XVII UISPP World Congress (1–7 September, Burgos, Spain). Volume 7/Sessions A4b and A12

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

This project intends to provide an integrated linguistic assessment of the hypothesised migration route of the Tocharians.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Accelerating the diagnosis and personalising the management of inherited metabolic diseases.

Anna Scott is a Canadian pianist-researcher interested in using the early twentieth century recordings of the Brahms circle of pianists to question persistent gaps between the loci of knowledge, ethics, and act in both modern mainstream and historically-informed performances of Brahms’s late piano w…

What can languages spoken in the Lesser Sunda Islands today tell us about the histories of its various population groups?

A technique originally developed for satellite imaging can now be used to recover pictographic texts from underneath the surface of a five hundred year old Mexican manuscript.

Attitudes towards cultural heritage have long been characterised by an ‘endangerment sensibility’ concerned with preventing losses. Recently, however, critical heritage scholars have argued that loss can be generative, facilitating the formation of new values and attachments. Their arguments have focused…

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

What kinds of vocal music were not typically transmitted in written musical notation? Can specific ‘lost’ song forms - siciliane, giustiniane, le Grechesche, gli stili “regionali“ nel canto del quattrocento - be more precisely identified than they have been until now, both in musicological research…

Female and male songbirds sing equally elaborate songs in some species, but in others, females do not sing like males or not at all. How did such pronounced differences in male and female communication evolve?

PhD defence

Since 2013, the National Natural History Museum of the Netherlands, Naturalis Biodiversity Center, is unearthing the largest bonebed of the horned dinosaur Triceratops discovered so far. In order to answer questions about sedimentology, taphonomy and palaeobiology, palaeontologists and geologists collaborated…

How to reconstruct the middle parts (videlicet haute-contres, tailles and quintes) from French orchestral pieces, which survived only in their reduced forms (featuring primarely dessus and continuo), according to historical examples?

Agricultural foods naturally vary in their detailed internal structure. To facilitate early detection of health hazards due to contamination or disease, predict maturity and minimize wastage, it is critical to take into account the internal characteristics of each individual product, as these enable…

In 2010, the remnants of a 16th century indigenous village were discovered in St. Vincent, on the construction terrain of the new International Argyle Airport.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

An enormous number of monumental buildings, such as burial tombs, appeared in Mycenaean Greece after 1600 BC. Why did this urge to build come to an abrupt end 400 years later? Archaeologist Ann Brysbaert investigates the possible causes thanks to her ERC Consolidator Grant.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…