855 search results for “acoustic signals” in the Public website
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Accent Building
A British English Pronunciation Course Book
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ARCHITECTURES OF SPEED - reinventing the tools, functions and potentials of speed within rhythmical frames in music
What are the precise identities, possibilities and current practice examples of the various time frames in music and what bearings do they have individually and in combinations on the speed of the music?
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Stop! Hey, what's that sound? the representation and realization of Danish stops
On the 11th of January, Rasmus Puggaard-Rode successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Rasmus on this achievement!
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Crossing boundaries in improvised music
Developing new methods for performing improvised music
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Prosody in whispered speech: retrieving alternative cues to pitch
The goal of this study is to systematically investigate how intonation (speech melody) is conveyed in whispered speech.
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Experimental Linguistics
How do we process language and speech? How do we integrate information at different levels – intonation, sentence structure, meaning, tone, words, sounds - and how does information at one level interact with information at another level?
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The noisy underwater world: the effect of sound on behaviour of captive zebrafish
Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn
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Cancer Therapeutics and Drug Safety
In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…
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Targeting SUMO Signaling to Wrestle Cancer
PhD defence
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Freedom of Additional Signals on Genes
PhD defence
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Two-photon luminescence of gold nanorods: applications to single-particle tracking and spectroscopy
Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.
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Chasing cosmic tau neutrinos in the abyss
In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.
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MYC transcription factors: masters in the regulation of jasmonate biosynthesis in Arabidopsis thaliana
Promotor: J.M. Memelink
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Research
Developing computational algorithms for structural biology -A high resolution, three dimensional view of a molecule provides detailed information that help elucidate its function: by knowing the exact arrangement of atoms in a molecule, we can understand disease, develop drugs to combat them and improve…
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How does the brain process smartphone interactions?
Smartphone behaviors are so common but how does the brain generate this behavior? The Cognition in the digital environment laboratory (CODELAB) investigated the brain activity surrounding smartphone interactions with the help of Artificial Intelligence. According to their research, the brain fluidly…
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Research lines
Physics and Engineering Approaches to Biomedicine and Pharmacology
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Physics and Engineering Approaches to Biomedicine and Pharmacology
Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.
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LED3 Lecture - Elucidating inositol pyrophosphate signaling with chemical tools
Lecture
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Representation and processing of pitch variation in tonal languages
This project examines how speakers store and process regular pitch variation.
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Single cell technologies for mechanobiology and mechanopharmacology
Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…
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Sound Investigation: Effects of noise on marine animals across trophic levels
Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…
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Expression and Recognition of Emotion in Native and Foreign Speech: The Case of Mandarin and Dutch
This study investigates the perception and production of emotional prosody by native and non-native listeners and speakers, i.e. Chinese and Dutch listeners and speakers, including Dutch L2 learners of Chinese.
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Centre for Digital Heritage (CDH)
The Centre for Digital Heritage undertakes collaborative international research in the field of Digital Heritage. It is an initiative of the University of York.
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Thinking about the quantum internet
Quantum computers deserve their own quantum internet. This is a network that dispatches information not in the form of bits - ones and zeros - but rather as qubits, just like in the quantum computer itself. In the view of Dirk Bouwmeester, a professor in Leiden’s Quantum Matter & Optics research group,…
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relationship between linguistic and speaker- dependent information in the acoustics of consonants
PhD defence
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Melody in speech
All languages use melody in speech, primarily via rises and falls of the pitch of voice. Such pitch variation is pervasive, offering a wide spectrum of nuance to sentences – an additional layer of meaning. For example, saying “yes” with a rising pitch implies a question (rather than an affirmation).…
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BAT: Breaking the Transmission of Anxiety in the Family
Parents may pass anxiety onto their offspring by exposing them to anxious behaviors in novel situations. Just as the parents’ anxious signals lead to anxiety, parents’ confident signals can ward off anxiety in the offspring. This project is seeking a new way to break anxiety transmission in the family…
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Making a technology sustainable that doesn’t even exist yet
Industrial ecologists Stefano Cucurachi and Flora Siebler are part of the new consortium PROGENY, which received 3.6 million euros from the European Commission. PROGENY is an exciting project that will study the possibilities of soap films for innovations, such as ultra-thin screens.
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Sodium ion binding pocket mutations and adenosine A2A receptor function
Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)
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Cancer Drug Target Discovery
We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.
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INFLANET - Training European Experts in Inflammation: from the molecular players to animal models and the bedside
How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?
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Mechanisms of Ewing sarcoma metastasis: biochemistry and biophysics
Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska
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Trans-kingdom DNA transfer
The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.
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Zebrafish xenograft model: identification of novel mechanisms driving prostate cancer metastasis
Prostate cancer (PCa) is one of the most prevalent cancer in males.
- Mathematical Institute
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Like me or else...
Nature, nurture and neural mechanisms of social emotion regulation in childhood
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Harmonic duality : from interval ratios and pitch distance to spectra and sensory dissonance
This dissertation derives from the development of tools for algorithmic composition which extract pitch materials from sound signals, analyzing them according to their timbral and harmonic properties, putting them into motion through diverse rhythmic and textural procedures.
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Advances in SQUID-detected Magnetic Resonance Force Microscopy
In this thesis, we describe the latest advances in SQUID-detected Magnetic Resonance Force Microscopy (MRFM).
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Host-Microbe Interactions in Animal Sciences
Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.
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Neutrinos From the Milky Way
Promotor: M. de Jong, Co-Promotor: Samtleben
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Exploration of the endocannabinoid system using metabolomics
To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.
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About the conference
The Co-Align Conference 2023 will be held on 16 May 2023 at Leiden University.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Gut Feelings: Vagal Stimulation Reduces Emotional Biases
Stimulating the vagus nerve, which provides a direct link between the gut and brain, makes people pay less attention to sad facial expressions. This research study by psychologists Katerina Johnson and Laura Steenbergen is published in the journal Neuroscience, and made it to the cover.
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Regulators of integrin α6β4 function
This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.
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Dynamic Nuclear Polarization agents
Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…
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Unravelling proteins by touch
How can we develop a new microscope that can distinguish individual atoms in proteins?