1,107 search results for “acute and chronic stress” in the Public website
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Triage of stroke patients in the chain of acute stroke care
PhD defence
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Glucocorticoid modulation of the immune response
Unraveling the immune-suppressive actions of drugs like prednisone.
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Plastic Health Summit in Amsterdam
The Plastic Soup Foundation and Parley for the Oceans hosted the very first Plastic Heath Summit in Amsterdam on 3 October, covering the most relevant and pressing health concerns surrounding plastics and human health. Beyond discussing the latest findings in the field we asked the urgent question:…
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Chemical tools to modulate endocannabinoid biosynthesis
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
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Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis, Nat. Comm. 2020
Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.
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Innovation in tradition
This dissertation explores the history of the language of a manuscript known as Tönnies Fonne's Russian-German Phrasebook (Pskov 1607).
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Bioengineering and biophysics of viral hemorrhagic fever
Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Ethnicity, Orthodoxy, and Policy in Medieval China: The Political Philosophy of Wang Tong (584?-617)
This research project focuses on the thoughts of ethnicity and political orthodoxy in Medieval China by investigating Wang Tong’s works.
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3D Image to Characterize and Optimize antibody-mediated antitumor immunity
Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…
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The limits of tolerance: before and after Brexit and the German Refugee Crisis
This study investigates how two social and political developments, in the UK and Germany, impacted on the experiences of minorities and the attitudes of majorities vis-à-vis tolerance in those two countries. The results provide a thought-provoking picture of the views of minority and majority groups…
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Legitimiteit en rechtswaarborgen bij gesloten plaatsing van kinderen
On 7 March 2019, Maria de Jong-de Kruijf defended her thesis 'Legitimiteit en rechtswaarborgen bij gesloten plaatsing van kinderen'. The doctoral research was supervised by Prof. mr. M.R. Bruning en Prof. mr. T. Liefaard.
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De Jongh & Fougère, Specters of Arendt
The threat of totalitarian domination; the rise of bureaucratic expertise; the resurgence of nationalisms and xenophobia; the claims of religion in secular societies; and the importance of robust legal and political institutions: these are among the main issues that mark—or specters that haunt—the 20th…
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Single-cell immune profiling of atherosclerosis: from omics to therapeutics
Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…
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Ageing
As a result of an increased life expectancy, more people suffer from chronic diseases and discomfort. Elderly patients may have multiple diseases simultaneously, with concomitant multiple medications.
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Immunity, Infection and Tolerance
The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.
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Phonetic experiments on the word and sentence prosody of Betawi Malay and Toba Batak
In this study Lilie Roosman describes the effects of prominence and boundary marking on the temporal and melodic structures of two regional languages of Indonesia, viz. Toba Batak, a stress language, and her native language Betawi Malay, a non-stress language.
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‘Good’ Parenting?
Evidence and Care-work in a home visiting program to promote maternal sensitivity and parental reflective functioning in Alexandra township, Johannesburg, South Africa.
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Prediction of human (CNS) target site concentrations in health and disease
Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…
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Members
LIBC Stress & Emotion is a network focusing on science valorisation and outreach, stimulating interdisciplinary exchange of knowledge and expertise on topics related to brain and cognition/Stress and Emotion. Its research members come from a broad and diverse spectrum of specialized academic fields…
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The right diagnosis and faster for women with heart problems
It often takes longer for women with heart problems to get the right diagnosis. In her Annie Romein-Verschoor Lecture, Professor Hester den Ruijter will talk about how hormones influence the heart and the importance of medical research that focuses specifically on women.
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Leiden University Medical Center
In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.
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Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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Application of zebrafish and murine models in lipoprotein metabolism and atherosclerosis research
Cardiovascular diseases are still a major concern for the global health.
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Therapeutic Immunomodulation
The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.
- Transformations in global climate finance
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Hebben reumapatiënten met hulp van placebotechnieken minder medicatie nodig?
From painful joints to intense fatigue: a third of rheumatism patients suffer serious effects from this chronic condition and rely long-term on medication. Leiden psychologists are to receive a subsidy from the Netherlands Arthritis Foundation to investigate whether placebo techniques can help patients…
- LED3 Lecture: Designing Modulators of Purinergic Signaling for Chronic Disease Treatment
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Molecular Signatures of the Evolving Immune Response in Mice following a Bordetella pertussis Infection
Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.
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Why are governments sharing intelligence on the Ukraine war with the public and what are the risks?
In this article, Thomas Maguire, assistant professor at the Institute of Governance and Global Affairs, examines the intelligence of the US, British and Ukrainian governments and NATO partners concerning Russia and its war against Ukraine. This article discusses how and why governments communicate intelligence…
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Cardiovascular Pharmacology
The Cardiovascular Pharmacology research group headed by Ilze Bot aims to elucidate the mechanisms that underlie atherosclerotic plaque destabilization, which is the key process that leads to acute cardiovascular syndromes such as a myocardial infarction or stroke.
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Development of innovative engineered models for viral diseases
A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…
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Hypermarker
Developing a clinical decision support tool that will make it easier for clinicians to personalise the treatment for patients with high blood pressure. The team is using AI, deep learning methods and patient cohort data from 11 European countries.
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Social Anxiety and Specific Phobia in Youth
From basic science to real-world interventions
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Impact of insect herbivory and microbial inoculants on the rhizosphere microbiome and volatilome
This thesis aims to investigate the effect of tripartite interaction between microbial inoculants, the plant, and herbivore insects on the rhizosphere microbiome and volatilome. We investigated the rhizosphere microbiome and volatilome of tomato plants exposed to insect herbivory and/or inoculated with…
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Disentangling drought-responsive traits with focus on Arabidopsis
In recent decades, climate change has led to more frequent and severe drought events, causing serious consequences such as increased forest mortality and significant crop yield losses. Understanding how drought affects plants, especially economically important herbaceous species, is crucial for predicting…
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Anxiety and cognitive performance: better insights and new treatments
How does stress influence cognitive performance? What is the role of selective attention to threatening information in this effect? Could we prevent stress-induced decline of cognitive performance with pharmacological interventions? Could we use resting state theta/beta ratio as a biomarker for cognitive…
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Growth-induced self-organization in bacterial colonies
Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.
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Dynamics of TNFalpha signaling and drug-related toxicity
In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.
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Clinical Psychology Lab
Psycho-physiological reactions to stress.
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Structural characterization of the cell envelope of Actinobacteria under changing environments
Bacteria have the ability to alter their morphology in order to adapt to changing environments.
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MicroSOS
The MicroSOS project is designed to bring together academic and industrial partners with different expertises to address challenges that agriculture is facing due to climate change and invests in the development of microbiome-based solutions towards more sustainable agricultural practices.
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Resilience Center Leiden
The Resilience Center Leiden investigates how stress impacts the mental health of young people. For that, the team studies a multitude of factors, such as childhood experiences, the social environment, psychological factors, and neurobiological factors. With this multidimensional approach, we aim to…
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THRIVE Study
Towards Health and Resilience in Volatile Environments - People differ in how they are impacted by and respond to stressful experiences. Why is that?
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Bridging the gap, Pelvic floor physical therapy in the treatment of chronic anal fissure
PhD defence
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Migraine@Work: work ability in employees with migraine
This study aims to answer two main research questions: (1) What are the main predictors of work ability in employees with migraine? (2) Can we optimise work ability in employees with migraine using a web-based intervention focused on these relevant predictors?
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Errol Neo
Science
y.y.neo@biology.leidenuniv.nl | +31 71 527 5065
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Arthur Ram
Science
a.f.j.ram@biology.leidenuniv.nl | +31 71 527 4914
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Placebo research: Pharmacological conditioning
The major aim is to examine the potential of learning the body to produce a similar physiological (autonomic, neuroendocrine, or immune) and physical (e.g., desensitization of persistent physical symptoms) response to placebo medication than to active medication (pharmacological conditioning). If proven…