1,393 search results for “ancient dna” in the Public website
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New generation of graphene biosensors based on smooth surfaces and sharp edges
The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…
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Urban Craftsmen and Traders in the Roman World
This volume, featuring sixteen contributions from leading Roman historians and archaeologists, sheds new light on approaches to the economic history of urban craftsmen and traders in the Roman world, with a particular emphasis on the imperial period.
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The Archaeology of Greater Nicoya
Two Decades of Research in Nicaragua and Costa Rica
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The Long Arab Conquest of Central Asia: Urban Change in Merv, Paikent, Balkh and Samarkand (651-821)
This PhD research aims to trace the impact of the Arab conquest, both immediate and long-term, on the material and social organization of Central Asia from 651 to 821 through an “urban change” perspective in four cities: Merv, Paikent, Balkh and Samarkand.
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Re-assessing the environmental impact of early Roman expansion
This project aims to explore the environmental impact of early Roman expansion (4th/3rd century BC) through a program of dating and ecological sampling of traces of field systems (centuriations).
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First patient in the Netherlands successfully treated with stem cell gene therapy
Researchers from the Leiden University Medical Center (LUMC) have successfully used stem cell gene therapy to treat a baby with the severe congenital immune disorder SCID. An important milestone: it is the first time stem cell gene therapy of Dutch origin has been administered to a patient, and also…
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Introducing: Pieter Houten
Pieter Houten is a PhD student in the ERC granted research project 'An Empire of 2000 Cities: urban networks and economic integration in the Roman empire', directed by Luuk De Ligt and John Bintliff (Archaeology).
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The development of the Proto-Indo-European syllabic liquids in Greek
Ancient Greek was spoken in a large number of different dialects. Although we do not find direct evidence for syllabic liquids in any of our sources, comparative evidence shows that these sounds must have been present in Proto-Greek, and that they were retained until comparatively recently in the prehistory…
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Key publications
Key research articles and book chapters of the Chromatin group.
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High fidelity DNA replication and repair
PhD defence
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Efficient targeting of the Trichoderma genome for industrial protein engineering
The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.
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Alessandro Aleo
Faculteit Archeologie
a.aleo@arch.leidenuniv.nl | +31 71 527 2727
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Yuye Que
Faculty of Humanities
y.que@hum.leidenuniv.nl | +31 71 527 1514
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Luuk de Ligt
Faculty of Humanities
l.de.ligt@hum.leidenuniv.nl | +31 71 527 2669
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Nico Staring
Faculty of Humanities
n.t.b.staring@hum.leidenuniv.nl | +31 71 527 2727
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Ruurd Halbertsma
Faculty of Humanities
r.b.halbertsma@hum.leidenuniv.nl | +31 71 527 2727
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Valentina Azzarà
Faculteit Archeologie
v.m.azzara@arch.leidenuniv.nl | +31 71 527 2727
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Gerard Versluis
Faculteit Rechtsgeleerdheid
g.h.a.versluis@law.leidenuniv.nl | +31 71 527 8515
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Annelou van Gijn
Faculteit Archeologie
a.l.van.gijn@arch.leidenuniv.nl | +31 71 527 2389
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Michael Kerschner
Faculteit Archeologie
m.kerschner@arch.leidenuniv.nl | +31 71 527 2727
- Laboratory for Ceramics Studies
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Quantifying nucleosome dynamicsand protein binding with PIE-FCCS and spFRET
In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…
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Our approach
Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:
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Responding to environmental cues: the adaptive qualities of chromatin compaction proteins
Promotor: M. Ubbink, Co-Promotor: R. T. Dame
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Helmut Schiessel Group - Theoretical Physics of Life Processes
The group Theoretical Physics of Life Processes, led by Helmut Schiessel, focuses on the physics of chromatin, the DNA-protein complex that fills the nuclei of eukaryotic cells.
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Self-assembly of Colloidal Particles
The miniaturization of machines towards the micron and nanoscale requires the development of joint-like elements that enable and constrain motion. We developed a facile method to create colloidal joints, that is, anisotropic colloidal particles functionalized with surface mobile DNA linkers that control…
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Fighting tumours with light
Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.
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The researchers
Professor of Ecotoxicology Martina Vijver and lecturer Maarten Schrama are the founders and managers of the Living Lab. As well as these two researchers, a number of other ecologists and biologists are involved in the research at the Lab.
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Centre for Microbial Cell Biology
The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.
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SDS-PAGE at the nanoscale: A nanorecorder for single molecule protein sequencing with graphene
Can we find new chemical and biological sensing routes on the edge and surface of graphene to improve the potential of graphene to act as a sensor?
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Moving Romans. Migration to Rome in the Principate.
Moving Romans offers an analysis of Roman migration by applying general insights, models and theories from the field of migration history.
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Paul Hooykaas
Science
p.j.j.hooykaas@biology.leidenuniv.nl | +31 71 527 4933
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On Composition in Herodian’s History of the Roman Emperors
In the History of the Roman Emperors, what does Herodian’s method of composition consist of and how does it relate to his writing intention, particularly in terms of political and moral idea(l)s?
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The Figure of Abraham in the Metrical Homilies of Jacob of Sarug: Its Literary and Theological Context
This project is a close and sensitive contextual study of Jacob of Sarug's (ca. 451-521 AD) metrical homily
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Asia Beyond Boundaries
Beyond Boundaries: Religion, Region, Language and the State is a major multidisciplinary research project which aims to re-vision the history of Asia in one of its most significant periods. The project is based at the British Museum, British Library and the School of Oriental and African Studies, and…
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Learning from the past
Leiden archaeologists investigate how people in the past impacted their environment. Together with scientists, environmental scientists, and humanities experts, they use this information to draw conclusions about the present – and show what we can learn from it for the future.
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Introducing: Damjan Donev
Damjan Donev is a PhD student in the ERC granted research project 'An Empire of 2000 Cities: urban networks and economic integration in the Roman empire', directed by Luuk De Ligt and John Bintliff (Archaeology).
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PhD Theses
A full overview of MacBio PhD Theses.
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Charlotte van der Voort
Faculty of Humanities
c.van.der.voort@hum.leidenuniv.nl | +31 71 527 2125
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Fokelien Kootstra
Faculty of Humanities
f.kootstra@hum.leidenuniv.nl | +31 71 527 2727
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Marike van Aerde
Faculteit Archeologie
m.e.j.j.van.aerde@arch.leidenuniv.nl | +31 71 527 1138
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Fungal Chitosans from Fermentation Mycelia for Plant Biostimulants (FunChi)
Our focus is to optimize the fungal cell wall to both increase chitin production and chitin extractability.
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Horizontal gene transfer and spreading of biosynthetic gene clusters and antimicrobial resistance
Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.
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Overcoming the Debye screening length with radiofrequency-operated graphene biosensors
Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?
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Involvement of host and bacterial factors in Agrobacterium-mediated transformation
Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.
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Bacterial Chromatin
The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…
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The mechanism of Agrobacterium-mediated transformation of eukaryotic cells
We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.
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Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.